Assistant professor at NEQUIMED-IQSC-USP. He is bachelor in Pharmacy & Biochemistry with PhD. in Chemistry from the Federal University of Minas Gerais. He has two post-docs: University of New Mexico (USA) and University of Duisburg-Essen (Germany). He has experience in drug discovery applying cheminformatics, medicinal chemistry and cell-based assays in cancer and neglected diseases. (Source: Lattes Curriculum)
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The drug discovery process is time-consuming and often leads to dead ends. This is especially true for the study of bioactive substance for cancer diseases, in which new therapeutic approaches are eagerly needed. Cathepsin inhibitors are described in the literature as potential novel antineoplastic compounds, inhibiting the migration and invasion of cancer cells. In this work, it is devis…
The prostate cancer has the highest incidence among all neoplasia in middle-age men. This pathology is hormone-dependent, being androgen receptor (AR) the target of choice for antitumoral drugs bicalutamide, flutamide e nilutamide. However, the androgen-ablation therapy may not be efficacious at the late-phase disease, and it is necessary to introduce AR-independent bioactive compounds. I…
Pancreatic Cancer has high mortality rate according to the Brazilian National Cancer Institute (INCA). Gemcitabine is a drug usually applied in this case, but it has many limitations. Therefore, novel therapeutic alternatives are needed. Cysteine proteases present enormous physiopathological relevance, being overexpressed in many Cancer types, including the pancreatic adenocarcinoma. Amon…
Cysteine protease inhibitors have been described as cytostatic agents working as inhibitors of metastasis in many neoplasias, among them in pancreatic cancer cell lines. These cells overexpress cysteine proteases. In this Project, in vitro assays using the pancreatic cell line (MIA PaCa-2) and Balb/C 3T3 clone A31 mouse fibroblasts will be used to determine the selectivity profile for a s…
The research of novel bioactive substances is directly linked to its mechanism of action. In vitro studies are of great importance to determine the mode of action and cell-based assays are cornerstone to this outcome. Here the analysis of cysteine protease inhibition by means of a fluorescent chemical probe is going to be proposed to observe whether there will be fluorescence reduction. T…
| 5 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 2 / 2 | Completed scholarships in Brazil |
| 9 / 7 | All research grants and scholarships |
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CV Lattes
ORCID