CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduation at Pharmacy from Universidade Estadual Paulista Júlio de Mesquita Filho (2016), master's at Pharmacy from Universidade Estadual Paulista Júlio de Mesquita Filho (2016) and doctorate at Pharmacy from Universidade Estadual Paulista Júlio de Mesquita Filho (2020). Has experience in Cell Biology, focusing on Biology of Cancer. (Source: Lattes Curriculum)
Recently, ruthenium complexes have occupied a prominent position in the search for new anti-cancer therapies due their potential of action, selectivity in tumor tissues and less toxicity compared to current platinum complexes in clinical use. The diversity of ligands has been shown to be crucial for these complexes reach multiple biological targets and thus overcome the limitation of curr…
Mycobacterium tuberculosis, the agent of tuberculosis, is responsible for the deaths of millions of people around the world and global economic losses of billions of dollars. Its mortality rate decreased globally in 2007, however, multidrug-resistant strains and co-infection with HIV have hindered attempts to control tuberculosis. Since 1960 no drugs against M. tuberculosis have been deve…
Tissue engineering and biotechnology are developing new techniques and new biomaterials for tissue regeneration and repair. Some biomaterials derived from collagen matrices are widely used in the medical material industry by reason of the collagen is the main structural protein of tissues. To be employed in a secure manner in the human body, a biomaterial should not be cytotoxic, genotoxi…
| 3 / 3 | Completed scholarships in Brazil |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 4 |
| Citations | 16 |
| Cit./Article | 4.0 |
| Data from Web of Science | |
DE SOUZA, P. C.; FERNANDES, G. F. S.; MARINO, L. B.; RIBEIRO, C. M.; DA SILVA, P. B.; CHORILLI, M.; SILVA, C. S. P.; RESENDE, F. A.; SOLCIA, M. C.; DE GRANDIS, R. A.; et al. Furoxan derivatives demonstrated in vivo efficacy by reducing Mycobacterium tuberculosis to undetectable levels in a mouse model of infection. BIOMEDICINE & PHARMACOTHERAPY, v. 130, OCT 2020. Web of Science Citations: 0. (18/11079-0, 18/00163-0, 14/03920-6, 17/12419-7, 16/09502-7, 14/02240-1, 13/14957-5, 16/02860-5, 14/24811-0, 16/24633-0, 18/17739-2, 15/19531-1, 16/22429-7, 14/11586-9)
DE GRANDIS, RONE APARECIDO; DA SILVA DOS SANTOS, PATRICK WELLINGTON; DE OLIVEIRA, KATIA MARA; TOMAZELA MACHADO, ANA RITA; AISSA, ALEXANDRE FERRO; BATISTA, ALZIR AZEVEDO; GREGGI ANTUNES, LUSANIA MARIA; PAVAN, FERNANDO ROGERIO. Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells. BIOORGANIC CHEMISTRY, v. 85, p. 455-468, APR 2019. Web of Science Citations: 3. (16/22429-7, 18/00163-0, 16/16312-0)
DE GRANDIS, RONE A.; DE CAMARGO, MARIANA S.; DA SILVA, MONIZE M.; LOPES, ERICA O.; PADILHA, ELIAS C.; RESENDE, FLAVIA A.; PECCININI, ROSANGELA G.; PAVAN, FERNANDO R.; DESIDERI, ALESSANDRO; BATISTA, ALZIR A.; et al. Human topoisomerase inhibition and DNA/BSA binding of Ru(II)-SCAR complexes as potential anticancer candidates for oral application. BIOMETALS, v. 30, n. 3, p. 321-334, JUN 2017. Web of Science Citations: 10. (12/22364-1, 13/20078-4)
DE CAMARGO, MARIANA S.; DE GRANDIS, RONE A.; DA SILVA, MONIZE M.; DA SILVA, PATRICIA B.; SANTONI, MARIANA M.; EISMANN, CARLOS E.; MENEGARIO, AMAURI A.; COMINETTI, MARCIA R.; ZANELLI, CLESLEI F.; PAVAN, FERNANDO R.; et al. Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors. BIOMETALS, v. 32, n. 1, p. 89-100, FEB 2019. Web of Science Citations: 3. (12/21529-7, 16/22429-7, 16/16312-0)
(References retrieved automatically from State of São Paulo Research Institutions)
GRANDIS, Rone Aparecido de. Avaliação toxicogenética e estudo dos mecanismos de resposta antiproliferativa de metalofármacos de rutênio contendo bioligantes naftoquinônicos em modelos celulares tumorais convencionais e em 3D. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas. (16/22429-7)