Abstract
Sickle Cell Anemia is a hereditary hemoglobinopathy resulting from a mutation of the beta-globin gene, leading to the production of hemoglobin S (HbS). During deoxygenation of erythrocytes, polymerization of Hb occurs, with consequent deformation, stiffening and weakening of red cells, resulting in Hemolytic Anemia, vaso-occlusive events and a chronic inflammatory condition with elevated …