- Research Grants
Consultant for DNDi Latin America (present) PhD in Biomolecular Physics at University of São Paulo, Brazil (2016). PhD internship at AbbVie pharmaceuticals, USA (2015-2016). Master?s in Cellular and Molecular Biology at PUCRS, Brazil (2011). During my training I was able to apply multiple strategies in the assessment of the potential of small molecules as new drug candidates. My goal is to use my expertise to rationally advance new promising molecules and understand new concepts across the multidisciplinary drug discovery pipeline. I have experience in both academy and industry, where I have had the chance to learn, apply, and implement state of the art methodologies and workflows in drug discovery. I enjoy to explore new endeavors, working in collaboration within research groups, and the steep learning curve they provide. (Source: Lattes Curriculum)
Chagas' disease, also known as American trypanosomiasis, affects millions of people worldwide, mostly in Latin America, and is considered one of the neglected tropical diseases (NTD) of highest priority in the "Lead Discovery for Drugs for Tropical Infectious Diseases" program of the World Health Organization (WHO). The available drugs to fight the disease are extremely limited and have...
Cruzain (EC 126.96.36.199) is the major cysteine protease from Trypanosoma cruzi, the Chagas disease etiological agent. Due to its biological relevance, this enzyme is considered one of the most relevant targets to develop new anti-chagasics, which is urgent once the available therapy is old and very toxic due to a blend of unsatisfactory side effects and lack of efficacy. In this way, the ...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
(References retrieved automatically from State of São Paulo Research Institutions)
PAULI, Ivaní. Planejamento de inibidores da enzima cruzaína candidatos a fármacos para o tratamento da doença de Chagas. 2016. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (11/13789-6)