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Luis Alexandre Pedro de Freitas

CV Lattes GoogleMyCitations ORCID


Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Bachelor in Chemical Enginering at Universidade Estadual de Campinas (1987), MSc and PhD in Chemical Engineering at Universidade Federal de São Carlos (1991, 1996). Has been lecturing at the Faculdade de Ciências Farmacêuticas de Ribeirão Preto since 1989. Has solid experience in Industrial Pharmacy, focusing on PharmaceuticalTechnology, acting on the following subjects: fluidized beds, spray drying, spray congealing, drying, granulation and coatiing, solid dispersions and factorial designs. (Source: Lattes Curriculum)

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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (32)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications26
Citations283
Cit./Article10.9
Data from Web of Science

COSTA, ANA R. M.; FREITAS, LUIS A. P.; MENDIOLA, J.; IBANEZ, E.. Copaifera langsdorffii supercritical fluid extraction: Chemical and functional characterization by LC/MS and in vitro assays. JOURNAL OF SUPERCRITICAL FLUIDS, v. 100, p. 86-96, . Web of Science Citations: 11. (13/16268-2)

MARTINS, RODRIGO MOLINA; SIQUEIRA, SILVIA; VIEIRA FONSECA, MARIA JOSE; PEDRO FREITAS, LUIS ALEXANDRE. Skin penetration and photoprotection of topical formulations containing benzophenone-3 solid lipid microparticles prepared by the solvent-free spray-congealing technique. Journal of Microencapsulation, v. 31, n. 7, p. 644-653, . Web of Science Citations: 9. (10/11602-3, 08/02848-9)

CABRAL, T. P. F.; BELLINI, N. C.; ASSIS, K. R.; TEIXEIRA, C. C. C.; LANCHOTE, A. D.; CABRAL, H.; FREITAS, L. A. P.. Microencapsulate Aspergillus niger peptidases from agroindustrial waste wheat bran: spray process evaluation and stability. Journal of Microencapsulation, v. 34, n. 6, p. 560-570, . Web of Science Citations: 0. (15/17995-0, 13/23327-5)

PEREIRA, SIMONE VIEIRA; COLOMBO, FABIO BELOTTI; MARTINS, RODRIGO MOLINA; PEDRO DE FREITAS, LUIS ALEXANDRE. Spray Cooling Process Factors and Quality Interactions During the Preparation of Microparticles Containing an Active Pharmaceutical Ingredient. Drying Technology, v. 32, n. 10, p. 1188-1199, . Web of Science Citations: 5. (10/02078-9, 08/02848-9)

ANDRADE, TONI C.; MARTINS, RODRIGO M.; FREITAS, LUIS ALEXANDRE P.. Granulation of indomethacin and a hydrophilic carrier by fluidized hot melt method: The drug solubility enhancement. Powder Technology, v. 270, n. B, SI, p. 453-460, . Web of Science Citations: 6. (05/05191-2)

MARRETO, RICARDO N.; RAMOS, MONICA F. S.; SILVA, EMMANUELLE J.; DE FREITAS, OSVALDO; DE FREITAS, LUIS A. P.. Impact of Cross-linking and Drying Method on Drug Delivery Performance of Casein-Pectin Microparticles. AAPS PHARMSCITECH, v. 14, n. 3, p. 1227-1235, . Web of Science Citations: 12.

MARTINS, RODRIGO MOLINA; SIQUEIRA, SILVIA; MACHADO, MARCELA OLAIA; PEDRO FREITAS, LUIS ALEXANDRE. The effect of homogenization method on the properties of carbamazepine microparticles prepared by spray congealing. Journal of Microencapsulation, v. 30, n. 7, p. 692-700, . Web of Science Citations: 10. (08/07115-0, 08/02848-9)

PEREIRA, SIMONE VIEIRA; REIS, RAYSSA A. S. P.; GARBUIO, DANIELLE CRISTINA; PEDRO DE FREITAS, LUIS ALEXANDRE. Dynamic maceration of Matricaria chamomilla inflorescences: optimal conditions for flavonoids and antioxidant activity. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 1, p. 111-117, . Web of Science Citations: 5. (15/25128-5)

GUIMARAES, THIAGO F.; COMELLI, AMANDA C. C.; TACON, LUCIANA A.; CUNHA, TALITA A.; MARRETO, RICARDO N.; FREITAS, LUIS A. P.. Fluidized Bed Hot Melt Granulation with Hydrophilic Materials Improves Enalapril Maleate Stability. AAPS PHARMSCITECH, v. 18, n. 4, p. 1302-1310, . Web of Science Citations: 4. (11/20872-7, 05/05191-2)

HAMIN NETO, YOUSSEF ALI ABOU; PEDRO DE FREITAS, LUIS ALEXANDRE; CABRAL, HAMILTON. Multivariate Analysis of the Stability of Spray-Dried Eupenicillium javanicum Peptidases. Drying Technology, v. 32, n. 5, p. 614-621, . Web of Science Citations: 5. (11/20872-7, 11/06986-0)

GUIMARAES, THIAGO FRANCES; LANCHOTE, AUREA D.; DA COSTA, JESSICA SILVA; VICOSA, ALESSANDRA LIFSITCH; PEDRO DE FREITAS, LUIS ALEXANDRE. A multivariate approach applied to quality on particle engineering of spray-dried mannitol. ADVANCED POWDER TECHNOLOGY, v. 26, n. 4, p. 1094-1101, . Web of Science Citations: 11. (11/20872-7)

TEIXEIRA, C. C. C.; MENDONCA, L. M.; BERGAMASCHI, M. M.; QUEIROZ, R. H. C.; SOUZA, G. E. P.; ANTUNES, L. M. G.; FREITAS, L. A. P.. Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity. AAPS PHARMSCITECH, v. 17, n. 2, p. 252-261, . Web of Science Citations: 20. (11/20872-7)

MARTINS, RODRIGO MOLINA; PEREIRA, SIMONE VIEIRA; SIQUEIRA, SILVIA; SALOMAO, WELLINGTON FIORAVANTE; PEDRO FREITAS, LUIS ALEXANDRE. Curcuminoid content and antioxidant activity in spray dried microparticles containing turmeric extract. Food Research International, v. 50, n. 2, SI, p. 657-663, . Web of Science Citations: 32. (08/07115-0, 08/02848-9)

KFURI‚ CR; FREITAS‚ LAP. A comparative study of spouted and spout-fluid beds for tablet coating. Drying Technology, v. 23, n. 12, p. 2369-2387, .

HAMIN NETO, YOUSSEF ALI ABOU; PEDRO DE FREITAS, LUIS ALEXANDRE; CABRAL, HAMILTON. Multivariate Analysis of the Stability of Spray-Dried Eupenicillium javanicum Peptidases. Drying Technology, v. 32, n. 5, p. 614-621, . Web of Science Citations: 5. (11/20872-7, 11/06986-0)

COSTA, ANA R. M.; FREITAS, LUIS A. P.; MENDIOLA, J.; IBANEZ, E.. Copaifera langsdorffii supercritical fluid extraction: Chemical and functional characterization by LC/MS and in vitro assays. JOURNAL OF SUPERCRITICAL FLUIDS, v. 100, p. 86-96, . Web of Science Citations: 11. (13/16268-2)

MARTINS, RODRIGO MOLINA; SIQUEIRA, SILVIA; VIEIRA FONSECA, MARIA JOSE; PEDRO FREITAS, LUIS ALEXANDRE. Skin penetration and photoprotection of topical formulations containing benzophenone-3 solid lipid microparticles prepared by the solvent-free spray-congealing technique. Journal of Microencapsulation, v. 31, n. 7, p. 644-653, . Web of Science Citations: 9. (08/02848-9, 10/11602-3)

PEREIRA, SIMONE VIEIRA; REIS, RAYSSA A. S. P.; GARBUIO, DANIELLE CRISTINA; PEDRO DE FREITAS, LUIS ALEXANDRE. Dynamic maceration of Matricaria chamomilla inflorescences: optimal conditions for flavonoids and antioxidant activity. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 1, p. 111-117, . Web of Science Citations: 5. (15/25128-5)

CABRAL, T. P. F.; BELLINI, N. C.; ASSIS, K. R.; TEIXEIRA, C. C. C.; LANCHOTE, A. D.; CABRAL, H.; FREITAS, L. A. P.. Microencapsulate Aspergillus niger peptidases from agroindustrial waste wheat bran: spray process evaluation and stability. Journal of Microencapsulation, v. 34, n. 6, p. 560-570, . Web of Science Citations: 0. (15/17995-0, 13/23327-5)

TEIXEIRA, CRISTIANE C. C.; DE PAIVA JUNIOR, ELIAS; PEDRO DE FREITAS, LUIS ALEXANDRE. Fluidized Bed Hot-Melt Granulation as a Tool to Improve Curcuminoid Solubility. AAPS PHARMSCITECH, v. 19, n. 3, p. 1061-1071, . Web of Science Citations: 3. (15/25128-5, 13/23327-5)

GUIMARAES, THIAGO FRANCES; LANCHOTE, AUREA D.; DA COSTA, JESSICA SILVA; VICOSA, ALESSANDRA LIFSITCH; PEDRO DE FREITAS, LUIS ALEXANDRE. A multivariate approach applied to quality on particle engineering of spray-dried mannitol. ADVANCED POWDER TECHNOLOGY, v. 26, n. 4, p. 1094-1101, . Web of Science Citations: 11. (11/20872-7)

PEDRO DE FREITAS, LUIS ALEXANDRE. Pharmaceutical applications of spouted beds: A review on solid dosage forms. PARTICUOLOGY, v. 42, n. SI, p. 126-136, . Web of Science Citations: 1. (15/25128-5)

FREITAS, L. V. D.; MONTES, A. C. R.; CAMPOS, E. I. A.; CONCEICAO, E. C.; TACON, L. A.; LANCHOTE, A. D.; FREITAS, L. A. P.. Rice spouted bed for manufacturing inclusion complexes of Endopleura uchi L extracts in beta-cyclodextrin. PARTICUOLOGY, v. 42, n. SI, p. 208-215, . Web of Science Citations: 1. (15/25128-5)

MARRETO, R. N.; PEIXOTO, M. P. G.; TEIXEIRA, C. C. C.; FREITAS, L. A. P.. ANALYSIS OF PRESSURE FLUCTUATIONS DURING WATER EVAPORATION IN SPOUTED BED. CANADIAN JOURNAL OF CHEMICAL ENGINEERING, v. 87, n. 3, p. 386-393, . Web of Science Citations: 7.

CHAVES, JULIANA SIQUEIRA; DA COSTA, FERNANDO BATISTA; PEDRO DE FREITAS, LUIS ALEXANDRE. Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L.). Brazilian Journal of Pharmaceutical Sciences, v. 45, n. 3, p. 573-584, . Web of Science Citations: 10.

MARTINS, RODRIGO MOLINA; PEREIRA, SIMONE VIEIRA; SIQUEIRA, SILVIA; SALOMAO, WELLINGTON FIORAVANTE; PEDRO FREITAS, LUIS ALEXANDRE. Curcuminoid content and antioxidant activity in spray dried microparticles containing turmeric extract. Food Research International, v. 50, n. 2, SI, p. 657-663, . Web of Science Citations: 32. (08/02848-9, 08/07115-0)

MARTINS, RODRIGO MOLINA; SIQUEIRA, SILVIA; PEDRO FREITAS, LUIS ALEXANDRE. Spray Congealing of Pharmaceuticals: Study on Production of Solid Dispersions Using Box-Behnken Design. Drying Technology, v. 30, n. 9, p. 935-945, . Web of Science Citations: 19. (08/02848-9, 08/07115-0)

MARTINS, R. M.; MACHADO, M. O.; PEREIRA, S. V.; NOSARI, A. B. F. L.; TACON, L. A.; FREITAS, L. A. P.. Microparticulated Hydrochlorothiazide Solid Dispersion: Enhancing Dissolution Properties via Spray Drying. Drying Technology, v. 30, n. 9, p. 959-967, . Web of Science Citations: 17. (08/02848-9)

TACON‚ L.A.; FREITAS‚ L.A.P.. Paste residence time in a spouted bed dryer. III: Effect of paste properties and quality interactions. Drying Technology, v. 25, n. 5, p. 841-852, .

MARRETO‚ RN; FREIRE‚ JT; FREITAS‚ LAP. Drying of pharmaceuticals: The applicability of spouted beds. Drying Technology, v. 24, n. 3, p. 327-338, .

KFURI‚ CR; FREITAS‚ LAP. A comparative study of spouted and spout-fluid beds for tablet coating. Drying Technology, v. 23, n. 12, p. 2369-2387, .

BORINI, G. B.; ANDRADE, T. C.; FREITAS, LUIS A. P.. Hot melt granulation of coarse pharmaceutical powders in a spouted bed. Powder Technology, v. 189, n. 3, p. 520-527, . Web of Science Citations: 47. (05/05191-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MARTINS, Rodrigo Molina. Influência de micro e nanopartículas lipídicas sólidas na eficácia de formulações fotoprotetoras bioativas. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (10/11602-3

SILVA, Andreza de Almeida e. Preparação e caracterização de granulados contendo dispersão sólida de praziquantel obtidos por fusão/solidificação em leito fluidizado. Dissertação (Mestrado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (06/05355-8

TAVEIRA, Stephânia Fleury. Nanopartículas Lipídicas Sólidas (NLS) como carreadores de fármacos para o tratamento tópico do câncer de pele. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (07/01730-1

GELFUSO, Guilherme Martins. Desenvolvimento de sistemas de liberação para a administração tópica passiva e iontoforética do minoxidil no tratamento da alopecia androgênica. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (06/01559-8

PEREIRA, Simone Vieira. Sistemas microestruturados contendo extratos de Chamomilla recutita L. para aplicações dermocosméticas. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (12/04018-9

NOSARI, Anna Beatriz Frejuello Limoli. Desenvolvimento e avaliação de micro e nanopartículas contendo óleo de café verde para aplicações dermocosméticas. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (12/04071-7

COSTA, Ana Rita de Mello. Lipossomas contendo ácido caurenoico ou extrato de Copaifera langsdorffii: desenvolvimento, caracterização e atividades antitumoral e tripanocida. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (12/02082-1

MARTINS, Rodrigo Molina. Desenvolvimento de dispersões sólidas microparticuladas contendo carbamazepina por spray congealing. Dissertação (Mestrado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (08/07115-0

PEREIRA, Simone Vieira. Obtenção de dispersões sólidas microparticuladas de piroxicam por spray congealing. Dissertação (Mestrado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (10/02078-9

Patent applications

MICROPARTÍCULAS E NANOPARTÍCULAS LIPÍDICAS SÓLIDAS BR1020120014483 - Universidade de São Paulo (USP). Luis Alexandre Pedro de Freitas; Anna Beatriz Frejuello Limoli Nosari - January 2012, 23

FORMULAÇÃO CONTENDO NANOPARTÍCULAS LIPÍDICAS SÓLIDAS DE FLAVONOIDE E USO DA MESMA BR1020150090188 - Universidade de São Paulo (USP). Cristina Mara Zamarioli; Luis Alexandre Pedro De Freitas; Rodrigo Molina Martins; Silvia De Siqueira - April 2015, 22

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020170240525 - Universidade de São Paulo (USP). Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - November 2017, 08

MICROPARTÍCULAS COMPREENDENDO MINOXIDIL, PROCESSO DE PRODUÇÃO E COMPOSIÇÃO COMPREENDENDO MICROPARTÍCULAS PI0901659-7 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de São Paulo (USP). Renata Fonseca Vianna Lopez; Guilherme Martins Gelfuso; Taís Gratieri - May 2009, 08

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