bachelor's at Ciências Biológicas Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (1999), master's at Pharmacology from Universidade Estadual Paulista Júlio de Mesquita Filho (2002) and doctorate at General Biology from Universidade Estadual de Campinas (2006). Has experience in Morphology, acting on the following subjects: rat, reproduction, fertility, fertilidade and rato. (Source: Lattes Curriculum)
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Exposure to Endocrine Disruptors (EDs) during critical windows of development can cause epigenetic alterations, which can appear immediately or long after exposure, even in subsequent generations. Benzo(a)pyrene (BaP) is a persistent organic pollutant, widely distributed in the environment. Studies have shown that BaP accumulates in vital and reproductive organs, including the testis; and…
Prostaglandins (PGE2) are essential in the process of hypothalamic sexual differentiation, promoting the masculinization of hypothalamus in males. The non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (third class of drugs most used by pregnant) act through non-selective inhibition of COX-1 and 2, with the reduction of PGE2. Thus, when used during pregnancy, these substanc…
Cyclophosphamide (CFA) is extensively used as chemotherapeutic agent in clinical practice for the treatment of cancers. However, this compound causes several adverse effects including reproductive toxicity. As alternative to minimize these adverse effects, the CFA is normally used in combination with antioxidants. Acrocomia aculeata is a common species of palm savanna, known traditionally…
Clinical depression is a common disorder observed in women of childbearing age, especially during pregnancy and postpartum. Venlafaxine, classified as a Serotonin and Norepinephrine Reuptake Inhibitor (SNRI), is one of the main options for the treatment of prenatal and postnatal depression. Since serotonin has an important role in the development of the central nervous system, in utero an…
Attention deficit hyperactivity disorder (ADHD) is one of the most diagnosed neuropsychiatric disorders in school-age children and adolescents. Studies show that catecholamine neurotransmission is impaired in the brain of these patients, and therefore, pharmacological treatment aims to increase the levels of these neurotransmitters through the use of psychostimulants. For having a more co…
Exposure to Endocrine Disruptors (EDs) during critical windows of development can causes epigenetic alterations, which can appear immediately or long after exposure, even in subsequent generations. Benzo(a)pyrene (BaP) is a persistent organic pollutant, widely distributed in the environment. Studies have shown that BaP accumulates in vital and reproductive organs, including the testis; an…
Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed neuropsychiatric disorders in school-age children and adolescents, in which catecholamine neurotransmission is impaired, thus pharmacological treatment aims to increase levels of neurotransmitters through psychostimulants. Amongst the most used drugs is Lisdexamfetamine Dimesylate (LDX), a prodrug of dex…
The symptoms of nausea and vomiting during pregnancy (NVP) are a clinically significant condition, capable of affecting more than 80% of pregnant women, interfering with the quality of life, and can lead to psychosocial impacts. Ondansetron, a highly selective 5HT-3 serotonin receptor antagonist, is used in the prevention and treatment of nausea and vomiting in general, induced by chemoth…
Estradiol is known to be crucial in the process of hypothalamic sexual differentiation, promoting the masculinization of the male hypothalamus. Tamoxifen, a selective non-steroidal estrogen receptor modulator, is used as adjuvant endocrine therapy in patients with hormone receptor-positive breast cancer. Since many breast cancer patients are in reproductive age, pregnancy is delayed until…
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Microglia is emerging as important regulators of brain development. This cell responds and produces prostaglandin E2 (PGE2), creating a feedback loop. PGE2 is related to inflammation, and early-onset neural inflammation is a leading environmental risk for some disorders. Microglia has a "semi-activation" peak during the second post-natal week in healthy cerebellum. Cerebellar development …
| 3 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 15 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 22 / 19 | All research grants and scholarships |
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CV Lattes
ORCID