Bachelor in physics from the Universidad Nacional de La Plata in 1993, Phd in the field of crystallography form the same institution in 1998. Currently Associate Professor A3 of the Physics Institute of São Carlos of the University of São Paulo where he coordinates the Graduate Program in Physics. Vice-President of the Brazilian Crystallography Association. Coordinator of the Structural Crystallography facility at the IFSC-USP (the oldest structural crystallography laboratory in the country).CNPq level 1B researcher, Co-editor of Acta Crystallographica E and member of the Structural Chemistry Committee of the International Union of Crystallography (IUCr) and CSD Champion of the Cambridge Crystallographic Data Center. He works as a reviewer for international scientific journals, ad hoc consultant for government institutions and advisor to several national and international institutions and companies. He has over 457 publications in indexed journals with over 5700 citations and has an H-index of 35 (WoS) and 41 on Google Scholar. Among other areas, he has dedicated himself to the planning, development, obtaining and characterization of new solid multicomponent forms of pharmaceutical ingredients with improved pharmacokinetic and pharmacotechnical properties. Within this area he co-organized the I and II Latin American Symposium on Polymorphism and Crystallization in Drugs and Medicines (LAPOLC 2007 and LAPOLC 2009) and was a consultant for ANVISA, INPI, SINDUSFARMA as well as a wide range of companies in the pharmaceutical and pharmochemical areas. He currently coordinates a PRONEX FAPESP/CNPQ Project in the area of Development of New Inorganic Chemotherapeutics. Other lines of action include the design and characterization of 3D Metal-Organic Coordination Complexes (Metal Organic Frameworks, MOF) and the study and characterization of Natural minerals, currently being vice-coordinator of the Center for the Characterization of Mineral Species (http://www .ifsc.usp.br/~emulabram/). He also has extensive experience in very varied topics such as the study of complexes of chelating ligands with heavy metals, catalytic and biological properties of coordination complexes containing, for example, Ru, Cu, V, Ni, etc. He also researches in the area of theoretical and experimental analysis of the electronic charge density of compounds with biological activity or non-linear optical properties. He was a member of the X-Ray Diffraction Committee of the National Synchrotron Light Laboratory, he served as vice-coordinator of the IFSC Postgraduate program from 2016 to 2018. He has supervised 7 doctoral thesis, 9 master's thesis and 38 Scientific Initiations. (Source: Lattes Curriculum)
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The present project aims the study of intermolecular interactions in transition metal complexes with organic ligands, with the objective of establishing the mechanism of action of these compounds as potential anticancer drugs, antituberculosis, antichagasic or antimalarial drugs. These studies consist of several steps that include the synthesis of the compounds, their spectroscopic charac…
This research project is focused to the synthesis of new crystalline forms of drugs used in the anti-HIV therapy, followed by the characterization of their solid state physical and chemical properties. These drugs will be subject of crystallization essays in order to obtain new crystalline forms with tailored pharmacokinetic properties. The produced crystalline forms will be characterized…
This research proposal is devoted to synthesize new crystalline forms of drugs that have been widely used in anti-HIV therapy, followed by solid state characterization of their physical and chemical properties. Anti-HIV drugs belonging to the inhibitor classes targeted on reverse transcriptase, both nucleoside and non-nucleoside compounds, and aspartate HIV protease will be subjects of cr…
The present project aim characterization, mainly by single crystal x-ray diffraction, as well as and the analisys of the structural and crystallographic properties analysis of organometallic complex with pharmacological activity. This project also involves the correlations of this structural information with the corresponding physical-chemical properties and biological application. The bi…
The present project aim the synthesis and characterizing ruthenium II semi-sandwich complexes containing binders of biological interest, as new candidates for metallopharmaceuticals, being an integral part of the thematic project "X-Ray Diffraction as a Tool in the Development of Potential Drugs" (2017 / 15850-0). In the synthesis stage, it is intended to perform a "screening" to evaluate…
This present research project is dedicated to desing and obtaining new multicomponent crystalline forms of antituberculosis drugs, followed by characterization of the physical and chemical properties in the solid state and subsequent evaluation of pharmacokinetic properties such as solubility and dissolution. New multicomponent crystalline forms have different chemical, conformational an…
The design, preparation and characterization of new crystalline forms of active pharmaceutical ingredients (API) with improved pharmacokinetic properties through molecular crystal engineering, is a research topic of great interest in the academic and industrial sectors. Inside this context, this research project is aimed at the design, synthesis, structural and supramolecular analysis of …
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This research proposal aims the development of theoretical and experimental Charge Density (CD) studies of new solid forms of antiretroviral drugs, initially of the lamivudine (3TC), one of the most marketed and effective anti-HIV and anti-hepatitis-B drug. The different solid forms derivatives of the lamivudine and other anti-HIV drugs have been obtaining through crystal engineering appr…
The depression have been characterized as one of most major global health challenge. In the disease treatment, the Selective Serotonin Reuptake Inhibitors (SSRIs) constitute a important pharmaceutical intervention. In particular, Paroxetine, Fluoxetine and Sertraline are antidepressants widely used in depression clinic treatment. This research project aims the development and characteriza…
| 1 / 1 | Ongoing research grants |
| 6 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 8 / 6 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 19 / 13 | All research grants and scholarships |
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CV Lattes
ORCID