Paulo José Samenho Moran

• Abstract

  Application of enzymatic processes to the synthesis of homochiral intermediates possessing one or more stereogenic elements will be the main focus of this project. Monitoring microorganisms available in brazilian culture collections will allow the detection of novel biocatalytic activities, mainly from enzymes belonging to oxide-reductases, hydrolases and laccases type. With this proposal…

  Biocatalysis in Organic Synthesis, AP.TEM
• Bioreduction of (e)-1-phenyl-1,2-alkanedione 2-(0-methyloxime)., AR.EXT

• Abstract

  Application of enzymatic processes to the synthesis of homochiral intermediates possessing one or more stereogenie elements will be the main focus of this project. Monitoring microorganisms available in brazilian culture collections will allowthe detection of novel biocatalytic activities mainly from enzymes belonging to the monooxigenase, oxido-reductase, hidrolase and haloperoxidase typ…

  Application of Biocatalysis to Organic Chemistry, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  In this project, the reductive dehalogenation mediated by Pichia stipitis of some alpha-haloketones giving the corresponding ketones and the action of some radical inhibitors in those biotransformations will be study.

  Study of the potential inhibition of free radical reactions of some products in Pichia stiptis cells using alpha-chloro and alpha-bromo-ketones, BP.IC

• Abstract

  In this project, we intend the synthesize prochiral alpha-chloroenones, alpha-bromoenones and alpha-methyleneketones that can be reduced to furnish chiral halohydrins, epoxides and alpha-methylketones of synthetic interest. We intend to investigate biocatalytic routes to produce these compounds in high yields and enantiomeric excesses. In the case of alpha-haloenones, we intend to study t…

  Study of enzymatic reductions of alpha,beta-unsaturated ketones, and their applications in the preparation of compounds of synthetic interest, BP.DR

• Abstract

  This project aims the chemi-enzimatic synthesis of optically active epoxyamine and epoxyazido used as chiral intermediaries in the synthesis of HIVPR inhibitors with hydroxiethylamine structure. The key step is the bioreduction of C=C and C=O by Saccharomyces cerevisiae or other microorganisms in the obtaintion of chiral centers in high enantimeric excess.

  ENANTIOSELECTIVE SYNTESIS OF CENTRAL STRUCTURE OF SOME INHIBITORS OF HIVPR BY BIOTRANSFOMATION OF SUBSTITUTED ENONES., BP.IC