Mozart de Azevedo Marins

• Abstract

  The Sp1 transcription factor is an important element in the development of osteosarcoma, the most common primary malignant bone tumor in children and adolescents, characterized by the rapid development of metastases. The genes encoding metalloproteinases, proteins associated with the mesenchymal epithelial transition (EMT), apoptosis and DNA repair are recognized targets of Sp1 that parti…

  Exploring the activity of transcription factor Sp1 associated to mesenchymal epithelial transition as a therapeutic target of osteosarcoma, AP.R

• Abstract

  A number of candidate anticancer agents have been designed and discovered in the laboratory of Professor Dimmock. These compounds display potent inhibitory effects on cell proliferation or are lethal to tumours. It is important to find the modes of action of representative lead molecules. The research group of Professor Marins has considerable experience in finding the ways in which cytot…

  Synthesis and discovery of molecular mechanisms of some novel conjugated unsaturated ketones designed as anticancer agents, AP.R SPRINT

• Abstract

  p53 protein is a transcription factor with tumor suppressor activity that plays a key role in the development of cancer. In most known cancers, p53 has its activity compromised by mutations in its protein sequence or by the deregulation of mechanisms that control its cellular levels, such as overexpression of the MDM2 protein, the major p53-negative regulator. Mutations in p53 may also gi…

  Bioscreening of polyphenols with anticancer activity and investigation of the molecular mechanisms involving the p53 transcription factor, AP.R

(Only some records are available in English at this moment)

• Establishment and maintenance of cell lines as tools of analysis of the mesenchymal epithelium transition process., BP.TT
• Transduction with shRNA library and generation of mutant strains in U2OS cells, BP.TT
• Screening of polyphenols with cytotoxic activity and inhibition of cell migration / invasion, BP.TT

(Only some records are available in English at this moment)