Mozart de Azevedo Marins
CV Lattes
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Universidade de Ribeirão Preto (UNAERP). Campus Ribeirão Preto (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciencias Biologicas from Universidade de São Paulo (1989) and ph.d. at Biochemistry from Universidade de São Paulo (1995). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: biologia molecular, pcr, ehrlichia canis, anaplasma and babesia. (Source: Lattes Curriculum)
- Synthesis and discovery of molecular mechanisms of some novel conjugated unsaturated ketones designed as anticancer agents, AP.R
Abstract
A number of candidate anticancer agents have been designed and discovered in the laboratory of Professor Dimmock. These compounds display potent inhibitory effects on cell proliferation or are lethal to tumours. It is important to find the modes of action of representative lead molecules. The research group of Professor Marins has considerable experience in finding the ways in which cyt...
- Bioscreening of polyphenols with anticancer activity and investigation of the molecular mechanisms involving the p53 transcription factor, AP.R
Abstract
p53 protein is a transcription factor with tumor suppressor activity that plays a key role in the development of cancer. In most known cancers, p53 has its activity compromised by mutations in its protein sequence or by the deregulation of mechanisms that control its cellular levels, such as overexpression of the MDM2 protein, the major p53-negative regulator. Mutations in p53 may also ...
- Molecular analysis of the response of human and canine tumor strain lines to the flavonoid trans-chalcone, AP.R
Abstract
Flavonoids are polyphenolic compounds of plant origin that are present in abundance in fruits, vegetables, teas and medicinal herbs. The different molecules in this class of compounds are explored for the development of chemotherapeutic agents with new targets or to sensitization of tumor cells to lower doses of conventional chemotherapeutic agents. Experiments conducted by our research...
- In vitro action of flavonoids in the canine malignant Histiocytic cell line DH82, PUB.ART
Abstract
Cancer is commonly diagnosed in dogs over the age of 10 and is a leading cause of death due to the lack of effective drugs. Flavonoids possess antioxidant, anti-inflammatory and anticarcinogenic properties and have been studied as chemopreventive agents in human cancer therapy. However, the literature on dogs is sparse. In this study, we analyzed the effect of nine flavonoids on cell vi...
(Only some records are available in English at this moment)
- Transduction with shRNA library and generation of mutant strains in U2OS cells, BP.TT
- Screening of polyphenols with cytotoxic activity and inhibition of cell migration / invasion, BP.TT
- Analysis of the effect of natural products in DNA methylation of canine tumor cells and in the process of Ehrlichia canis infection, BP.IC
Abstract
The epigenetic mechanisms of gene expression control participate in the cellular response to environmental signals of biotic and abiotic nature, which reflects in the processes of cell differentiation, development of genetic and infectious diseases. The identification and analysis of these mechanisms have allowed for the development of "epigenetic drugs" to fight cancer and is exemplif...
(Only some records are available in English at this moment)
*Updated June 15, 2019
| 1 / 1 | Ongoing research grants |
| 10 / 6 | Completed research grants |
| 22 / 12 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 34 / 19 | All Research Grants and Scholarships |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 73 |
| Cit./Article | 6.1 |
| Data from Web of Science | |
CARDOZO, G. P.; SANTOS, E. V.; FACHIN, A. L.; FRANCA, S. C.; MARINS, M.. A glass bead protocol for recovery of host cell free Ehrlichia canis and quantification by Sybr-green real-time PCR. BIOCELL, v. 35, n. 1, p. 35-36, APR 2011. Web of Science Citations: 2.
OLIVEIRA, L. P.; CARDOZO, G. P.; SANTOS, V, E.; MANSUR, M. A. B.; DONINI, I. A. N.; ZISSOU, V. G.; ROBERTO, P. G.; MARINS, M.. MOLECULAR ANALYSIS OF THE rRNA GENES OF BABESIA SPP AND EHRLICHIA CANIS DETECTED IN DOGS FROM RIBEIRAO PRETO, BRAZIL. Brazilian Journal of Microbiology, v. 40, n. 2, p. 238-240, APR-JUN 2009. Web of Science Citations: 5. (06/04413-4, 06/07117-7)
CARDOZO, G. P.; OLIVEIRA, L. P.; MANSUR, M. A. B.; SANTOS, E. V.; ROBERTO, P. G.; MARINS, M.. Molecular characterisation of two strains of Anaplasma platys in Brazil. VETERINARY RECORD, v. 164, n. 11, p. 338-339, MAR 14 2009. Web of Science Citations: 3. (06/04413-4)
SANTOS, FLAVIA; COPPEDE, JULIANA S.; PEREIRA, ANDRE L. A.; OLIVEIRA, LETICIA P.; ROBERTO, PATRICIA G.; BENEDETTI, ROBERTA B. R.; ZUCOLOTO, LENISE B.; LUCAS, FLAVIA; SOBREIRA, LUCIA; MARINS, MOZART. Molecular evaluation of the incidence of Ehrlichia canis, Anaplasma platys and Babesia spp. in dogs from Ribeirao Preto, Brazil. VETERINARY JOURNAL, v. 179, n. 1, p. 145-148, JAN 2009. Web of Science Citations: 47. (05/03953-2)
SILVA, GABRIEL; LIMA, FELIPE TEIXEIRA; SEBA, VIVIANE; MENDES LOURENCO, ANA LAURA; LUCAS, THAISE GRAMINHA; DE ANDRADE, BIANCA VIEIRA; TORREZAN, GUILHERME SILVA; POLAQUINI, CARLOS ROBERTO; GARCIA, MARCELO ENGRACIA; COUTO, LUCELIO BERNARDES; et al. Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27. Molecules, v. 23, n. 2, FEB 2018. Web of Science Citations: 4. (14/18330-0, 14/15307-7, 17/03237-2)
LIMA, FELIPE TEIXEIRA; SEBA, VIVIANE; SILVA, GABRIEL; TORREZAN, GUILHERME SILVA; POLAQUINI, CARLOS ROBERTO; PINHANELLI, VITOR CARESSATO; BAEK, SEUNG J.; FACHIN, ANA LUCIA; REGASINI, LUIS OCTAVIO; MARINS, MOZART. The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 7, JUL 2018. Web of Science Citations: 0. (14/18330-0, 14/15307-7, 17/03237-2)
SILVA, GABRIEL; MARINS, MOZART; CHAICHANASAK, NADDA; YOON, YONGDAE; FACHIN, ANA LUCIA; PINHANELLI, VITOR CARESSATO; REGASINI, LUIS OCTAVIO; DOS SANTOS, MARIANA BASTOS; AYUSSO, GABRIELA MIRANDA; MARQUES, BEATRIZ DE CARVALHO; et al. Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition. PLoS One, v. 13, n. 8, AUG 17 2018. Web of Science Citations: 1. (14/15307-7)
SILVA, GABRIEL; FACHIN, ANA LUCIA; BELEBONI, RENE O.; FRANCA, SUZELEI C.; MARINS, MOZART. In Vitro Action of Flavonoids in the Canine Malignant Histiocytic Cell Line DH82. Molecules, v. 18, n. 12, p. 15448-15463, DEC 2013. Web of Science Citations: 7. (10/18122-7)
SANTOS, E. V.; SILVA, G.; CARDOZO, G. P.; BITENCOURT, T. A.; FRANCA, S. C.; FACHIN, A. L.; MARINS, M.. In silico characterization of three two-component systems of Ehrlichia canis and evaluation of a natural plant-derived inhibitor. Genetics and Molecular Research, v. 11, n. 4, p. 3576-3584, 2012. Web of Science Citations: 0. (08/08146-6, 08/04778-8, 08/05011-2)
C. HERNANDES; G.P. CARDOZO; S.C. FRANÇA; A.L. FACHIN; M. MARINS; M.V LOURENÇO. Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line. Revista Brasileira de Plantas Medicinais, v. 14, n. 1, p. 122-124, 2012. (08/09815-9)
SEBA, VIVIANE; SILVA, GABRIEL; DOS SANTOS, MARIANA BASTOS; BAEK, SEUNG JOON; FRANCA, SUZELEI DE CASTRO; FACHIN, ANA LUCIA; REGASINI, LUIS OCTAVIO; MARINS, MOZART. Chalcone Derivatives 4 `-Amino-1-Naphthyl-Chalcone (D14) and 4 `-Amino-4-Methyl-1-Naphthyl-Chalcone (D15) Suppress Migration and Invasion of Osteosarcoma Cells Mediated by p53 Regulating EMT-Related Genes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 9, SEP 2018. Web of Science Citations: 0. (14/15307-7, 17/03237-2)
. Analysis of the 16S rRNA gene of Anaplasma platys detected in dogs from Brazil. Brazilian Journal of Microbiology, v. 38, n. 3, p. -, Set. 2007. (06/04413-4)
PINHANELLI, V. C.; COSTA, P. N. M.; SILVA, G.; AGUIAR, D. M.; SILVA, C. M. L.; FACHIN, A. L.; MARINS, M.. Development and evaluation of a loop-mediated isothermal amplification assay for detection of Ehrlichia canis DNA in naturally infected dogs using the p30 gene. Genetics and Molecular Research, v. 14, n. 4, p. 17885-17892, 2015. Web of Science Citations: 0. (12/15940-6, 12/01235-9)
SANTOS, MARIANA B.; PINHANELLI, VITOR C.; GARCIA, MAYARA A. R.; SILVA, GABRIEL; BAEK, SEUNG J.; FRANCA, SUZELEI C.; FACHIN, ANA L.; MARINS, MOZART; REGASINI, LUIS O.. Antiproliferative and pro-apoptotic activities of 2 `- and 4 `-aminochalcones against tumor canine cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 138, p. 884-889, SEP 29 2017. Web of Science Citations: 4. (14/18330-0, 14/15307-7)