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Francisco Rafael Martins Laurindo

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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Francisco R. M. Laurindo graduated in Medicine by the University of São Paulo School of Medicine, São Paulo, Brazil , in 1978 and completed his residence training in Internal Medicine and Cardiology at the Heart Institute(Incor), University of São Paulo School of Medicine. After a period (1982-84) as associate physician at the same institution, he underwent research training in Physiology and Pharmacology at the Uniformed Services University of the Health Sciences, in Bethesda, Maryland (under Dr. Robert Goldstein, 1984-87). Back to the Heart Institute, University of São Paulo School of Medicine, he started an investigative research track focused on mechanisms of redox signaling processes in the vascular system. He obtained his PhD in 1992, supervised by Dr. Protásio da Luz. Thereafter, he conducted several research projects through independent financial support from research agencies. In 2001, he started, together with Dr. Protásio da Luz, the Vascular Biology Laboratory at the Heart Institute (Incor), University of São Paulo School of Medicine and became its Director in 2008, until presently. His major research interests have focused on understanding mechanisms and regulatory processes underlying the production of oxidant species in vascular cells and tissues and their physiological implications for vessel remodeling in disease. The most important contributions of his group have been the original description of shear stress-dependent generation of superoxide radical from the endothelium, the multi-level characterization of redox response to vascular injury and, particularly, the original discovery that the endoplasmic reticulum chaperone protein disulfide isomerase interacts functionally and physically with oxidant-generating NADPH oxidase complexes. This finding had relevant implications regarding the role of endoplasmic reticulum (patho)physiology on NADPH oxidase function and how redox processes regulate cell migration and vascular remodeling. More recently, Dr. Laurindo's group showed an important role for extracellular PDI in arterial remodeling after injury. Dr. Laurindo has authored or co-authored over 145 publications in peer-reviewed journals, cited >3500 times (h-index=35 (ISI)). He supervised 18 PhD students and 17 post-doctoral fellows, in addition to several undergraduate trainees. From 2008-14, he was the vice-coordinator of the National Institute for Science and Technology of Redox Processes in Biomedicine (CNPq/Fapesp) and since 2013 (until present) the Vice-coordinator and principal investigator of Cepid-Fapesp Redoxoma. He is a member of the Brazilian Academy of Sciences since 2012 and a member of its Board of Directors since 2016, a member of Fapesp Study Committee in Health Sciences from 2008-2016 and Fapesp Advisor Committee in Life Sciences since 2016, a member of Capes Federal Agency Committee (Medicine) from 1998-2017. He served as Council Member of the Society for Free Radical Biology and Medicine from 2010-2014 and belongs to the Editorial Board of Free Radical Biology and Medicine since 2008 and of Clinical Science since 2012. He has been an ad-hoc consultant for >35 publications and research agencies from Brazil and abroad. He was elected as vice-chair (2014) and chair (2016) of the Gordon Research Conference on Nox Family NADPH Oxidases. (Source: Lattes Curriculum)

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Enzyme may indicate predisposition to cardiovascular disease 
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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (39)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications33
Citations405
Cit./Article12.3
Data from Web of Science

BASSI, E.; LIBERMAN, M.; MARTINATTI, M. K.; BORTOLOTTO, L. A.; LAURINDO, F. R. M.. Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis. Brazilian Journal of Medical and Biological Research, v. 47, n. 2, p. 119-127, . Web of Science Citations: 3.

GODOY, LUIZ C.; MORETTI, ANA I.; JURADO, MARCIA C.; OXER, DANIELLA; JANISZEWSKI, MARIANO; CKLESS, KARINA; VELASCO, IRINEU T.; LAURINDO, FRANCISCO R. M.; SOUZA, HERALDO P.. LOSS OF CD40 ENDOGENOUS S-NITROSYLATION DURING INFLAMMATORY RESPONSE IN ENDOTOXEMIC MICE AND PATIENTS WITH SEPSIS. Shock, v. 33, n. 6, p. 626-633, . Web of Science Citations: 15.

MONTEIRO‚ H.P.; ROCHA OLIVEIRA‚ C.J.; CURCIO‚ M.F.; MORAES‚ M.S.; ARAI‚ R.J.. Tyrosine Phosphorylation in Nitric Oxide-Mediated Signaling Events. Methods in Enzymology, v. 396, p. 350-358, . (00/12154-2)

TREVELIN, SILVIA C.; CARLOS, DANIELA; BERETTA, MATTEO; DA SILVA, JOAO S.; CUNHA, FERNANDO Q.. Diabetes Mellitus and Sepsis: A Challenging Association. Shock, v. 47, n. 3, p. 276-287, . Web of Science Citations: 12. (13/08216-2, 11/03293-3, 11/19670-0, 09/54764-6)

SOARES MORETTI, ANA IOCHABEL; MARTINS LAURINDO, FRANCISCO RAFAEL. Protein disulfide isomerases: Redox connections in and out of the endoplasmic reticulum. Archives of Biochemistry and Biophysics, v. 617, n. SI, p. 106-119, . Web of Science Citations: 29. (13/07937-8, 14/23657-8, 09/54764-6)

GIMENEZ, MARCELA; SCHICKLING, BRANDON M.; LOPES, LUCIA R.; MILLER, JR., FRANCIS J.. Nox1 in cardiovascular diseases: regulation and pathophysiology. Clinical Science, v. 130, n. 3, p. 151-165, . Web of Science Citations: 17. (13/18300-0, 13/03520-5, 13/07937-8, 09/54764-6)

ARAUJO, THAIS L. S.; ZEIDLERA, JULIANNA D.; OLIVEIRA, PERCILLIA V. S.; DIAS, MATHEUS H.; ARMELIN, HUGO A.; LAURINDO, FRANCISCO R. M.. Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes. Free Radical Biology and Medicine, v. 103, p. 199-208, . Web of Science Citations: 11. (12/02372-0, 13/07937-8, 14/20595-1, 09/54764-6)

ARAUJO, THAIS L. S.; FERNANDES, CAROLINA G.; LAURINDO, FRANCISCO R. M.. Golgi-independent routes support protein disulfide isomerase externalization in vascular smooth muscle cells. REDOX BIOLOGY, v. 12, p. 1004-1010, . Web of Science Citations: 5. (13/07937-8, 15/06210-2, 12/02372-0)

TANAKA, LEONARDO Y.; LAURINDO, FRANCISCO R. M.. Vascular remodeling: A redox-modulated mechanism of vessel caliber regulation. Free Radical Biology and Medicine, v. 109, n. SI, p. 11-21, . Web of Science Citations: 0. (13/17115-5, 13/07937-8, 09/54764-6)

TREVELIN, SILVIA CELLONE; DOS SANTOS, CELIO XAVIER; FERREIRA, RAPHAEL GOMES; LIMA, LARISSA DE SA; SILVA, RANGEL LEAL; SCAVONE, CRISTOFORO; CURI, RUI; CARLOS ALVES-FILHO, JOSE; CUNHA, THIAGO MATTAR; ROXO-JUNIOR, PERSIO; et al. Apocynin and Nox2 regulate NF-kappa B by modifying thioredoxin-1 redox-state. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 14. (11/03293-3, 11/19670-0, 13/08216-2, 13/03520-5, 13/07937-8, 12/24677-7, 09/54764-6)

TANAKA, LEONARDO YUJI; GRASSMANN BECHARA, LUIZ ROBERTO; DOS SANTOS, ADRIANA MARQUES; JORDAO, CAMILA PAIXAO; OLIVEIRA DE SOUSA, LUIS GUSTAVO; BARTHOLOMEU, TERESA; VENTURA, LAURA INES; MARTINS LAURINDO, FRANCISCO RAFAEL; RAMIRES, PAULO RIZZO. Exercise improves endothelial function: A local analysis of production of nitric oxide and reactive oxygen species. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 45, p. 7-14, . Web of Science Citations: 21.

CHIGNALIA, ANDREIA Z.; OLIVEIRA, MARIA APARECIDA; DEBBAS, VICTOR; DULL, RANDAL O.; LAURINDO, FRANCISCO R. M.; TOUYZ, RHIAN M.; CARVALHO, MARIA HELENA C.; FORTES, ZULEICA B.; TOSTES, RITA C.. Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clinical Science, v. 129, n. 1, p. 39-48, . Web of Science Citations: 17.

LAURINDO, FRANCISCO R. M.; ARAUJO, THAIS L. S.; ABRAHAO, THALITA B.. Nox NADPH Oxidases and the Endoplasmic Reticulum. Antioxidants & Redox Signaling, v. 20, n. 17, p. 2755-2775, . Web of Science Citations: 68. (09/54764-6)

DEMASI, MARILENE; SIMOES, VANESSA; BONATTO, DIEGO. Cross-talk between redox regulation and the ubiquitin-proteasome system in mammalian cell differentiation. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1850, n. 8, SI, p. 1594-1606, . Web of Science Citations: 7. (11/23268-3, 09/54764-6)

TREVELIN, SILVIA CELLONE; LOPES, LUCIA ROSSETTI. Protein Disulfide Isomerase and Nox: New Partners in Redox Signaling. CURRENT PHARMACEUTICAL DESIGN, v. 21, n. 41, p. 5951-5963, . Web of Science Citations: 18. (13/07937-8, 13/03520-5, 09/54764-6)

NOGUEIRA, ADRIANO BARRETO; SOGAYAR, MARI CLEIDE; COLQUHOUN, ALISON; SIQUEIRA, SHEILA APARECIDA; NOGUEIRA, ARIEL BARRETO; MARCHIORI, PAULO EURIPEDES; TEIXEIRA, MANOEL JACOBSEN. Existence of a potential neurogenic system in the adult human brain. JOURNAL OF TRANSLATIONAL MEDICINE, v. 12, . Web of Science Citations: 25.

TANAKA, LEONARDO Y.; LAURINDO, FRANCISCO R. M.. Vascular remodeling: A redox-modulated mechanism of vessel caliber regulation. Free Radical Biology and Medicine, v. 109, n. SI, p. 11-21, . Web of Science Citations: 13. (13/17115-5, 13/07937-8, 09/54764-6)

GUIDO, MARIA C.; DEBBAS, VICTOR; SALEMI, VERA M.; TAVARES, ELAINE R.; MEIRELLES, THAYNA; ARAUJO, THAIS L. S.; NOLASCO, PATRICIA; FERREIRA-FILHO, JULIO C. A.; TAKIMURA, CELSO K.; PEREIRA, LYGIA V.; et al. Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, . Web of Science Citations: 0. (13/07937-8, 09/54764-6)

TANAKA, LEONARDO Y.; ARAUJO, HANIEL A.; HIRONAKA, GUSTAVO K.; ARAUJO, THAIS L. S.; TAKIMURA, CELSO K.; RODRIGUEZ, ANDRES I.; CASAGRANDE, ANNELISE S.; GUTIERREZ, PAULO S.; LEMOS-NETO, PEDRO ALVES; LAURINDO, FRANCISCO R. M.. Peri/Epicellular Protein Disulfide Isomerase Sustains Vascular Lumen Caliber Through an Anticonstrictive Remodeling Effect. Hypertension, v. 67, n. 3, p. 613-622, . Web of Science Citations: 14. (13/07937-8, 10/06360-0, 09/54764-6)

MEIRELLES, THAYNA; ARAUJO, THAIS L. S.; NOLASCO, PATRICIA; MORETTI, ANA I. S.; GUIDO, MARIA C.; DEBBAS, VICTOR; PEREIRA, LYGIA V.; LAURINDO, FRANCISCO R.. Fibrillin-1 mg Delta(lPn) Marfan syndrome mutation associates with preserved proteostasis and bypass of a protein disulfide isomerase-dependent quality checkpoint. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, v. 71, p. 81-91, . Web of Science Citations: 5. (12/23490-0, 13/07937-8, 09/54764-6)

WATANABE, MONICA M.; LAURINDO, FRANCISCO R. M.; FERNANDES, DENISE C.. Methods of measuring protein disulfide isomerase activity: a critical overview. FRONTIERS IN CHEMISTRY, v. 2, . Web of Science Citations: 15. (13/07937-8, 09/54764-6)

MORETTI, ANA I. S.; PAVANELLI, JESSYCA C.; NOLASCO, PATRICIA; LEISEGANG, MATTHIAS S.; TANAKA, LEONARDO Y.; FERNANDES, CAROLINA G.; WOSNIAK, JR., JOAO; KAJIHARA, DANIELA; DIAS, MATHEUS H.; FERNANDES, DENISE C.; et al. Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families. SCIENTIFIC REPORTS, v. 7, . Web of Science Citations: 5. (13/07937-8, 14/24511-7, 12/10203-3, 09/54764-6, 15/15281-0)

OLIVEIRA, PERCILLIA V. S.; LAURINDO, FRANCISCO R. M.. Implications of plasma thiol redox in disease. Clinical Science, v. 132, n. 12, p. 1257-1280, . Web of Science Citations: 10. (13/07937-8, 14/20595-1)

AMANSO, ANGELICA M.; DEBBAS, VICTOR; LAURINDO, FRANCISCO R. M.. Proteasome Inhibition Represses Unfolded Protein Response and Nox4, Sensitizing Vascular Cells to Endoplasmic Reticulum Stress-Induced Death. PLoS One, v. 6, n. 1, . Web of Science Citations: 26. (04/13683-0, 09/54764-6)

MONTEIRO, H. P.; SILVA, E. F.; STERN, A.. Nitric oxide: a potential inducer of adhesion-related apoptosis-anoikis. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 10, n. 1, p. 1-10, . (00/12154-2)

KRIEGER, M. H.; SANTOS, K. F. R.; SHISHIDO, S. M.; WANSCHEL, A. C. B. A.; ESTRELA, H. F. G.; SANTOS, L.; OLIVEIRA, M. G. DE; FRANCHINI, K. G.; SPADARI-BRATFISCH, R. C.; LAURINDO, F. R. M.. Antiatherogenic effects of S-nitroso-N-acetylcysteine in hypercholesterolemic LDL receptor knockout mice. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 14, n. 1, p. 12-20, . (00/12154-2)

SAN MARTIN, ALEJANDRA; FONCEA, ROCIO; LAURINDO, FRANCISCO R.; EBENSPERGER, ROBERTO; GRIENDLING, KATHY K.; LEIGHTON, FEDERICO. Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products. Free Radical Biology and Medicine, v. 42, n. 11, p. 1671-1679, . (00/12154-2)

DE ANDRADE, C. R.; LEITE, P. F.; MONTEZANO, A. C.; CASOLARI, D. A.; YOGI, A.; TOSTES, R. C.; HADDAD, R.; EBERLIN, M. N.; LAURINDO, F. R. M.; DE SOUZA, H. P.; et al. Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia. British Journal of Pharmacology, v. 157, n. 4, p. 568-580, . Web of Science Citations: 11. (04/13683-0)

DE BESSA, TIPHANY CORALIE; PAGANO, ALESSANDRA; SOARES MORETTI, ANA IOCHABEL; SANTOS OLIVEIRA, PERCILLIA VICTORIA; MENDONCA, SAMIR ANDRADE; KOVACIC, HERVE; MARTINS LAURINDO, FRANCISCO RAFAEL. Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas. CELL DEATH & DISEASE, v. 10, . Web of Science Citations: 1. (13/07937-8, 13/02070-6, 14/20595-1, 09/54764-6, 16/00686-8)

TANAKA, LEONARDO Y.; ARAUJO, THAIS L. S.; RODRIGUEZ, I, ANDRES; FERRAZ, MARIANA S.; PELEGATI, VITOR B.; MORAIS, MAURO C. C.; DOS SANTOS, ALINE M.; CESAR, CARLOS L.; RAMOS, ALEXANDRE F.; ALENCAR, ADRIANO M.; et al. Peri/epicellular protein disulfide isomerase-A1 acts as an upstream organizer of cytoskeletal mechanoadaptation in vascular smooth muscle cells. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 316, n. 3, p. H566-H579, . Web of Science Citations: 1. (13/07937-8, 13/17115-5, 15/06210-2)

CARMO, LUCIANA S.; BURDMANN, EMMANUEL A.; FESSEL, MELISSA R.; ALMEIDA, YOURI E.; PESCATORE, LUCIANA A.; FARIAS-SILVA, ELISANGELA; GAMARRA, LIONEL F.; LOPES, GABRIEL H.; ALOIA, THIAGO P. A.; LIBERMAN, MARCEL. Expansive Vascular Remodeling and Increased Vascular Calcification Response to Cholecalciferol in a Murine Model of Obesity and Insulin Resistance. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, v. 39, n. 2, p. 200-211, . Web of Science Citations: 3. (13/09652-0, 13/09611-2, 15/25923-0)

GIMENEZ, MARCELA; VERISSIMO-FILHO, SIDNEY; WITTIG, ILKA; SCHICKLING, BRANDON M.; HAHNER, FABIAN; SCHUERMANN, CHRISTOPH; NETTO, LUIS E. S.; ROSA, JOSE CESAR; BRANDES, RALF P.; SARTORETTO, SIMONE; et al. Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47(phox) in Vascular Smooth Muscle Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, v. 39, n. 2, p. 224-236, . Web of Science Citations: 0. (13/07937-8, 13/03520-5, 09/54764-6)

JOSHI, SUHASINI; WANG, TAI; ARAUJO, THAIS L. S.; SHARMA, SAHIL; BRODSKY, JEFFREY L.; CHIOSIS, GABRIELA. Adapting to stress - chaperome networks in cancer. NATURE REVIEWS CANCER, v. 18, n. 9, p. 562-575, . Web of Science Citations: 15. (17/01130-6)

C.M. PERTRINI; A.A. MIYAKAWA; F.R.M. LAURINDO; J.E. KRIEGER. Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress. Brazilian Journal of Medical and Biological Research, v. 36, n. 9, p. 1175-1178, . (00/12154-2, 01/00009-0)

SANTOS DE OLIVEIRA, PERCILLIA VICTORIA; GARCIA-ROSA, SHEILA; AZEVEDO SACHETTO, ANA TERESA; SOARES MORETTI, ANA IOCHABEL; DEBBAS, VICTOR; DE BESSA, TIPHANY CORALIE; SILVA, NATHALIA TENGUAN; PEREIRA, ALEXANDRE DA COSTA; MARTINS-DE-SOUZA, DANIEL; SANTORO, MARCELO LARAMI; et al. Protein disulfide isomerase plasma levels in healthy humans reveal proteomic signatures involved in contrasting endothelial phenotypes. REDOX BIOLOGY, v. 22, . Web of Science Citations: 0. (13/07937-8, 13/25177-0, 18/07511-4, 13/08711-3, 17/19866-9, 17/25588-1, 14/10068-4, 14/20595-1)

ARAUJO, THAIS L. S.; VENTURINI, GABRIELA; MORETTI, ANA I. S.; TANAKA, LEONARDO Y.; PEREIRA, ALEXANDRE COSTA; LAURINDO, FRANCISCO R. M.. Cell-surface HSP70 associates with thrombomodulin in endothelial cells. CELL STRESS & CHAPERONES, v. 24, n. 1, p. 273-282, . Web of Science Citations: 1. (13/07937-8, 15/06210-2)

AMANSO‚ A.M.; DEBBAS‚ V.; LAURINDO‚ F.R.M.. Proteasome Inhibition Represses Unfolded Protein Response and Nox4‚ Sensitizing Vascular Cells to Endoplasmic Reticulum Stress-Induced Death. PLoS One, v. 6, n. 1, p. e14591, . (04/13683-0, 09/54764-6)

ARAI, ROBERTO J.; OGATA, FERNANDO T.; BATISTA, WAGNER L.; MASUTANI, HIROSHI; YODOI, JUNJI; DEBBAS, VICTOR; AUGUSTO, OHARA; STERN, ARNOLD; MONTEIRO, HUGO P.. Thioredoxin-1 promotes survival in cells exposed to S-nitrosoglutathione: Correlation with reduction of intracellular levels of nitrosothiols and up-regulation of the ERK1/2 MAP Kinases. Toxicology and Applied Pharmacology, v. 233, n. 2, p. 227-237, . Web of Science Citations: 23. (00/12154-2)

PESCATORE, LUCIANA A.; GAMARRA, LIONEL F.; LIBERMAN, MARCEL. Multifaceted Mechanisms of Vascular Calcification in Aging. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, v. 39, n. 7, p. 1307-1316, . Web of Science Citations: 0. (16/17961-1, 16/21470-3, 15/25923-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ALVES, Luciana Pescatore. Papel da dissulfeto isomerase proteica (PDI) na migração de células musculares lisas vasculares: possível envolvimento de Nox1 NADPH oxidase e RhoGTPases. 2012. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (07/53171-6)

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