André Ricardo de Lima Damasio
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
André Damasio is an Industrial Pharmacist. He obtained his Ph.D. in biochemistry in 2011, with emphasis on Biochemistry of Microorganisms, at the Ribeirão Preto School of Medicine, University of São Paulo. During his Ph.D. he joined the Department of Microbiology and Molecular Genetics at Oklahoma State University, OK, USA (2009) to work on the production of client proteins in Aspergillus strains. Also, in 2010 he joined the Institute of Catalysis and Petrochemistry / CSIC, Madrid, Spain, to work on the immobilization and stabilization of target enzymes. Since 2011 he joined the Brazilian Bioethanol Science and Technology Laboratory, Campinas-SP, initially as a postdoctoral fellow (2011-2013) and then as Research Scientist (2013-2015). Currently he is Assistant Professor at the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), where he founded the Laboratory of Enzymology and Molecular Biology of Microorganisms (LEBIMO). His research focuses on the production of enzymes for the conversion of lignocellulosic biomass to biofuels and high-added value products through the genetic improvement of filamentous fungal strains. In addition, some projects underway at LEBIMO address the discovery of new enzymes, the biological importance of some enzymes and the improvement of catalytic efficiency by protein engineering. Moreover, ongoing research in LEBIMO aims to evaluate the relationship between sirtuins and virulence, using Aspergillus fumigatus as a model. LEBIMO is a member of the São Paulo Fungal Group (SPFG). (Source: Lattes Curriculum)
- N-glycosylation and enzymes secretion in filamentous fungi, AP.BIOEN.R
Abstract
Considering the entire conversion of plant biomass into bioproducts, such as the ethanol obtained from sugarcane bagasse (E2G), the enzymes make up a significant percentage of overall cellulosic ethanol production costs, ranging from 28% for off-site production to 22% for on-site and 10% for integrated enzyme production. The global market for industrial enzymes is expected to reach near...
- An integrated approach to explore a novel paradigm for biofuel production from lignocellulosic feedstocks, AP.TEM
Abstract
In this project we intend to demonstrate that it is more sensible (logical and economic) not to pre-treat lignocellulose so harshly, and have a more "holistic" approach to the process delivering the desired products whilst minimising overall process energy and cost by working on the optimisation of generating partial breakdown products and ensuring that the subsequent fermentation organ...
- 40th symposium on biotechnology for fuels and chemicals, AR.EXT
- Secretion of heterologous glycoproteins in Aspergillus: effect of glycosylation pattern in functional parameters of glycosyl hydrolases, AP.BIOEN.JP
Abstract
Only a third of the biomass of sugarcane is processed into ethanol, while the other two thirds are dropped as bagasse and straw. Cellulose and hemicellulose are the most abundant polymers in sugar cane bagasse, and have a very complex arrangement in the cell wall. Cellulases and hemicellulases are glycoside hydrolases responsible for the complete hydrolysis of plants cell-wall polysacch...
- Deletion of N-glycosylation pathway genes in Aspergillus nidulans, BP.TT
- Effect of synthetic lysine deacetylases (KDACs) inhibitors in Aspergillus fumigatus: potential antifungal drugs, BP.MS
Abstract
In the past few years, invasive fungal infections have been among the major causes of mortality and morbidity in immunocompromised individuals. One and a half million deaths are estimated per year, being the Aspergillus fumigatus the main invasive aspergillosis agent. Characteristics such as morphogenetic changes, host adaptation, and antifungals resistance contribute to the fungus viru...
- Influence of transcription factors on the secretion of enzymes in Aspergillus nidulans, BP.MS
Abstract
As a way to lessen dependence on fossil fuels, second-generation ethanol, obtained through the enzymatic hydrolysis of plant biomass, has been the focus of several scientific investigations. However, the recalcitrance of the plant cell wall and the high price of the hydrolytic enzymes mean that its complete and efficient degradation is still a challenge to be overcome for its economic v...
- Genetic engineering of a fungal platform to secrete lignocellulolytic enzymes for oligosaccharide production, BP.PD
Abstract
Several compounds of interest have been obtained through the fermentation of monosaccharides from the degradation of plant biomass. Nevertheless, the use of oligosaccharides, instead of monosaccharides, could bring advantages because it can decrease the competition with contaminants in the fermentation process. This strategy is possible through engineering of Saccharomyces cerevisiae st...
- Functional and biological analyses of LPMO (Lytic Polysaccharide Monooxigenases) and accessory proteins (non-CAZymes) for degradation of sugarcane straw by filamentous fungi, BP.PD
Abstract
Due to the heterogeneity and recalcitrance of plant cell wall, its complete and efficient degradation is a challenge to be overcome aiming the economic viability of second-generation ethanol. The development of new and improved enzyme cocktails requires greater knowledge of the active proteins in order to be optimized for the specific degradation of certain biomass. One of the most sign...
- Comparative analysis of the heterologous protein secretion mechanisms in Aspergillus nidulans, BP.MS
Abstract
As a way to reduce the use of energy from fossil fuels and increase the use of renewable energy, the second-generation ethanol obtained from the conversion of lignocellulosic plant biomass into fermentable sugars has been the focus of much research nowadays as a way to enable its use. Filamentous fungi stand out in the production and secretion of lignocellulolytic homologous and heterol...
(Only some records are available in English at this moment)
- Spectroscopic and structural investigations on target fungal Lytic Polysaccharide Monooxygenases, BE.EP.PD
Abstract
The understanding of enzymatic polysaccharide degradation has advanced in the past few years due to the identification of the lytic polysaccharide monooxygenases (LPMOs), which enhanced enzymatic conversion of lignocelluloses in fermentable sugars. In the fungal kingdom, saprotrophic fungi display a high number of genes encoding AA9LPMOs, but the differences of these enzymes are not ful...
- Genetic engineering of fungal strains using CRISPR/Cas9 multiplex to produce tailor-made cellulolytic cocktails, BE.EP.PD
Abstract
Complete degradation of plant biomass using enzymes is a key step for biofuel production inthe biorefinery context. The assimilation of oligosaccharides by fermentative microorganisms,instead of monosaccharides, is considered advantageous since it can decrease the competitionwith possible contaminants, resulting in improvements regarding process yield andproductivity. For this purpose, ...
- Deletion of genes related to the proteins secretion pathway in Aspergillus nidulans, BE.EP.DR
Abstract
In eukaryotes, the unfolded protein response (UPR) up-regulates genes responsible for restoring homeostasis in the endoplasmic reticulum (ER) during the accumulation of unfolded or misfolded proteins. Conditions that overload the ER with these proteins include environmental stresses, changes in the ER redox status, and expression of heterologous proteins by biological systems such as fi...
| 2 / 2 | Ongoing research grants |
| 4 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 11 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 23 / 20 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 21 |
| Citations | 358 |
| Cit./Article | 17.0 |
| Data from Web of Science | |
RIBEIRO, LILIANE F. C.; DE LUCAS, ROSYMAR C.; VITCOSQUE, GABRIELA L.; RIBEIRO, LUCAS F.; WARD, RICHARD J.; RUBIO, MARCELO V.; DAMASIO, ANDRE R. L.; SQUINA, FABIO M.; GREGORY, REBECCA C.; WALTON, PAUL H.; et al. A novel thermostable xylanase GH10 from Malbranchea pulchella expressed in Aspergillus nidulans with potential applications in biotechnology. BIOTECHNOLOGY FOR BIOFUELS, v. 7, JUL 29 2014. Web of Science Citations: 29. (10/18850-2, 12/02017-5, 10/07133-8, 12/12859-3, 10/10184-3, 13/18910-3, 08/57908-6)
DOS REIS ALMEIDA, FAUSTO BRUNO; PIGOSSO, LAURINE LACERDA; DE LIMA DAMASIO, ANDRE RICARDO; MONTEIRO, VALDIRENE NEVES; DE ALMEIDA SOARES, CELIA MARIA; SILVA, ROBERTO NASCIMENTO; ROQUE-BARREIRA, MARIA CRISTINA. alpha-(1,4)-Amylase, but not alpha- and beta-(1,3)-glucanases, may be responsible for the impaired growth and morphogenesis of Paracoccidioides brasiliensis induced by N-glycosylation inhibition. YEAST, v. 31, n. 1, p. 1-11, JAN 2014. Web of Science Citations: 8. (11/02169-7, 06/60642-2, 09/51197-3)
DAMASIO, ANDRE R. L.; PINTO BRAGA, CLEITON MARCIO; BRENELLI, LIVIA B.; CITADINI, ANA PAULA; MANDELLI, FERNANDA; COTA, JUNIO; DE ALMEIDA, RODRIGO FERREIRA; SALVADOR, VICTOR HUGO; ALVAREDO PAIXAO, DOUGLAS ANTONIO; SEGATO, FERNANDO; et al. Biomass-to-bio-products application of feruloyl esterase from Aspergillus clavatus. Applied Microbiology and Biotechnology, v. 97, n. 15, p. 6759-6767, AUG 2013. Web of Science Citations: 34. (11/02169-7, 09/17956-4, 08/58037-9)
COTA, JUNIO; OLIVEIRA, LEANDRO C.; DAMASIO, ANDRE R. L.; CITADINI, ANA P.; HOFFMAM, ZAIRA B.; ALVAREZ, THABATA M.; CODIMA, CARLA A.; LEITE, VITOR B. P.; PASTORE, GLAUCIA; DE OLIVEIRA-NETO, MARIO; et al. Assembling a xylanase-lichenase chimera through all-atom molecular dynamics simulations. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1834, n. 8, p. 1492-1500, AUG 2013. Web of Science Citations: 16. (11/13242-7, 08/58037-9, 11/02169-7)
GONCALVES, T. A.; DAMASIO, A. R. L.; SEGATO, F.; ALVAREZ, T. M.; BRAGATTO, J.; BRENELLI, L. B.; CITADINI, A. P. S.; MURAKAMI, M. T.; RULLER, R.; PAES LEME, A. F.; et al. Functional characterization and synergic action of fungal xylanase and arabinofuranosidase for production of xylooligosaccharides. Bioresource Technology, v. 119, p. 293-299, SEP 2012. Web of Science Citations: 44. (11/02169-7, 10/11469-1, 10/18198-3)
DAMASIO, ANDRE R. L.; RUBIO, MARCELO V.; OLIVEIRA, LEANDRO C.; SEGATO, FERNANDO; DIAS, BRUNO A.; CITADINI, ANA P.; PAIXAO, DOUGLAS A.; SQUINA, FABIO M.. Understanding the Function of Conserved Variations in the Catalytic Loops of Fungal Glycoside Hydrolase Family 12. Biotechnology and Bioengineering, v. 111, n. 8, p. 1494-1505, AUG 2014. Web of Science Citations: 13. (11/13242-7, 12/12859-3, 08/58037-9)
KAUPERT NETO, ANTONIO ADALBERTO; BORIN, GUSTAVO PAGOTTO; GOLDMAN, GUSTAVO HENRIQUE; DE LIMA DAMASIO, ANDRE RICARDO; DE CASTRO OLIVEIRA, JULIANA VELASCO. Insights into the plant polysaccharide degradation potential of the xylanolytic yeast Pseudozyma brasiliensis. FEMS Yeast Research, v. 16, n. 2, MAR 2016. Web of Science Citations: 1. (13/18910-3, 14/11766-7, 15/08222-8)
FURTADO, GILVAN P.; SANTOS, CAMILA R.; CORDEIRO, ROSA L.; RIBEIRO, LUCAS F.; DE MORAES, LUIZ A. B.; DAMASIO, ANDR R. L.; POLIZELI, MARIA DE LOURDES T. M.; LOURENZONI, MARCOS R.; MURAKAMI, MARIO T.; WARD, RICHARD J.. Enhanced xyloglucan-specific endo-beta-1,4-glucanase efficiency in an engineered CBM44-XegA chimera. Applied Microbiology and Biotechnology, v. 99, n. 12, p. 5095-5107, JUN 2015. Web of Science Citations: 10. (10/18850-2, 14/07135-1, 10/07133-8, 13/13309-0, 12/20549-4, 13/18910-3)
GOLDBECK, ROSANA; DAMASIO, ANDRE R. L.; GONCALVES, THIAGO A.; MACHADO, CARLA B.; PAIXAO, DOUGLAS A. A.; WOLF, LUCIA D.; MANDELLI, FERNANDA; ROCHA, GEORGE J. M.; RULLER, ROBERTO; SQUINA, FABIO M.. Development of hemicellulolytic enzyme mixtures for plant biomass deconstruction on target biotechnological applications. Applied Microbiology and Biotechnology, v. 98, n. 20, p. 8513-8525, OCT 2014. Web of Science Citations: 23. (13/18910-3, 08/58037-9, 12/18859-5)
SODRE, VICTORIA; ARAUJO, JUSCEMACIA NASCIMENTO; GONCALVES, THIAGO AUGUSTO; VILELA, NATHALIA; KIMUS BRAZ, ANTONIO SERGIO; FRANCO, TELMA TEIXEIRA; NETO, MARIO DE OLIVEIRA; DE LIMA DAMASIO, ANDRE RICARDO; GARCIA, WANIUS; SQUINA, FABIO MARCIO. An alkaline active feruloyl-CoA synthetase from soil metagenome as a potential key enzyme for lignin valorization strategies. PLoS One, v. 14, n. 2, FEB 25 2019. Web of Science Citations: 0. (15/50612-8, 17/16976-8, 17/17275-3, 18/18101-1, 17/05901-7, 17/22669-0, 17/08166-6, 15/50590-4, 17/16089-1)
ZUBIETA, MARIANE PALUDETTI; CONTESINI, FABIANO JARES; RUBIO, MARCELO VENTURA; DE SOUZA SCHMIDT GONCALVES, ANY ELISA; GERHARDT, JAQUELINE ALINE; PRADE, ROLF ALEXANDER; DE LIMA DAMASIO, ANDRE RICARDO. Protein profile in Aspergillus nidulans recombinant strains overproducing heterologous enzymes. MICROBIAL BIOTECHNOLOGY, v. 11, n. 2, p. 346-358, MAR 2018. Web of Science Citations: 3. (12/20549-4)
CONTESINI, FABIANO JARES; LIBERATO, MARCELO VIZONA; RUBIO, MARCELO VENTURA; CALZADO, FELIPE; ZUBIETA, MARIANE PALUDETTI; RIANO-PACHON, DIEGO MAURICIO; SQUINA, FABIO MARCIO; BRACHT, FABRICIO; SKAF, MUNIR S.; DAMASIO, ANDRE RICARDO. Structural and functional characterization of a highly secreted alpha-L-arabinofuranosidase (GH62) from Aspergillus nidulans grown on sugarcane bagasse. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1865, n. 12, p. 1758-1769, DEC 2017. Web of Science Citations: 3. (14/23051-2, 12/20549-4, 13/08293-7, 14/04105-4, 08/58037-9, 14/15403-6, 13/24988-5)
TRAMONTINA, ROBSON; FRANCO CAIRO, JOAO PAULO L.; LIBERATO, MARCELO V.; MANDELLI, FERNANDA; SOUSA, AMANDA; SANTOS, SAMANTHA; RABELO, SARITA CANDIDA; CAMPOS, BRUNA; IENCZAK, JACIANE; RULLER, ROBERTO; et al. The Coptotermes gestroi aldo-keto reductase: a multipurpose enzyme for biorefinery applications. BIOTECHNOLOGY FOR BIOFUELS, v. 10, JAN 3 2017. Web of Science Citations: 5. (13/06336-0, 12/20549-4, 14/20576-7, 14/04105-4, 08/58037-9)
DE VRIES, RONALD P.; RILEY, ROBERT; WIEBENGA, AD; AGUILAR-OSORIO, GUILLERMO; AMILLIS, SOTIRIS; UCHIMA, CRISTIANE AKEMI; ANDERLUH, GREGOR; ASADOLLAHI, MOJTABA; ASKIN, MARION; BARRY, KERRIE; et al. Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biology, v. 18, FEB 14 2017. Web of Science Citations: 99. (12/20549-4, 12/19040-0, 14/11766-7, 14/10351-8, 11/08945-9, 14/06923-6)
GOLDBECK, ROSANA; GONCALVES, THIAGO A.; DAMASIO, ANDRE R. L.; BRENELLI, LIVIA B.; WOLF, LUCIA D.; PAIXAO, DOUGLAS A. A.; ROCHA, GEORGE J. M.; SQUINA, FABIO M.. Effect of hemicellulolytic enzymes to improve sugarcane bagasse saccharification and xylooligosaccharides production. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, v. 131, p. 36-46, SEP 2016. Web of Science Citations: 6. (12/20549-4, 12/18859-5)
VITCOSQUE, GABRIELA LEAL; RIBEIRO, LILIANE FRAGA COSTA; DE LUCAS, ROSYMAR COUTINHO; DA SILVA, TONY MARCIO; RIBEIRO, LUCAS FERREIRA; DE LIMA DAMASIO, ANDRE RICARDO; FARINAS, CRISTIANE SANCHEZ; LOPES GONCALVES, ALINE ZORZETTO; SEGATO, FERNANDO; BUCKERIDGE, MARCOS SILVEIRA; et al. The functional properties of a xyloglucanase (GH12) of Aspergillus terreus expressed in Aspergillus nidulans may increase performance of biomass degradation. Applied Microbiology and Biotechnology, v. 100, n. 21, p. 9133-9144, NOV 2016. Web of Science Citations: 3. (14/18714-2, 10/10184-3, 12/20549-4)
RUBIO, MARCELO VENTURA; ZUBIETA, MARIANE PALUDETTI; LOURENO FRANCO CAIRO, JOAO PAULO; CALZADO, FELIPE; PAES LEME, ADRIANA FRANCO; SQUINA, FABIO MARCIO; PRADE, ROLF ALEXANDER; DE LIMA DAMASIO, ANDRE RICARDO. Mapping N-linked glycosylation of carbohydrate-active enzymes in the secretome of Aspergillus nidulans grown on lignocellulose. BIOTECHNOLOGY FOR BIOFUELS, v. 9, AUG 8 2016. Web of Science Citations: 9. (11/20977-3, 14/23051-2, 09/54067-3, 12/20549-4, 14/06923-6, 14/15403-6, 13/24988-5)
CALZADO, FELIPE; PRATES, ERICA T.; GONCALVES, THIAGO A.; RUBIO, MARCELO V.; ZUBIETA, MARIANE P.; SQUINA, FABIO M.; SKAF, MUNIR S.; DAMASIO, ANDRE R. L.. Molecular basis of substrate recognition and specificity revealed in family 12 glycoside hydrolases. Biotechnology and Bioengineering, v. 113, n. 12, p. 2577-2586, DEC 2016. Web of Science Citations: 5. (14/23051-2, 12/20549-4, 13/08293-7, 13/24988-5, 14/06923-6)
DE LIMA DAMASIO, ANDRE RICARDO; RUBIO, MARCELO VENTURA; GONCALVES, THIAGO AUGUSTO; PERSINOTI, GABRIELA FELIX; SEGATO, FERNANDO; PRADE, ROLF ALEXANDER; CONTESINI, FABIANO JARES; DE SOUZA, AMANDA PEREIRA; BUCKERIDGE, MARCOS SILVEIRA; SQUINA, FABIO MARCIO. Xyloglucan breakdown by endo-xyloglucanase family 74 from Aspergillus fumigatus. Applied Microbiology and Biotechnology, v. 101, n. 7, p. 2893-2903, APR 2017. Web of Science Citations: 7. (14/18714-2, 11/02169-7, 12/20549-4, 08/58037-9)
LIMA, MATHEUS S.; DAMASIO, ANDRE R. DE L.; CRNKOVIC, PAULA M.; PINTO, MARCELO R.; DA SILVA, ANA M.; DA SILVA, JEANC. R.; SEGATO, FERNANDO; DE LUCAS, ROSYMAR C.; JORGE, JOAO A.; POLIZELI, MARIA DE L. T. DE M.. Co-cultivation of Aspergillus nidulans Recombinant Strains Produces an Enzymatic Cocktail as Alternative to Alkaline Sugarcane Bagasse Pretreatment. FRONTIERS IN MICROBIOLOGY, v. 7, APR 28 2016. Web of Science Citations: 6. (13/18910-3, 12/20549-4)
SEGATO, FERNANDO; DAMASIO, ANDRE R. L.; DE LUCAS, ROSYMAR C.; SQUINA, FABIO M.; PRADE, ROLF A.. Genomics Review of Holocellulose Deconstruction by Aspergilli. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, v. 78, n. 4, p. 588-613, DEC 2014. Web of Science Citations: 34. (13/18910-3, 12/20549-4, 08/58037-9, 10/18198-3)
(References retrieved automatically from State of São Paulo Research Institutions)
DAMASIO, André Ricardo de Lima. Investigação do sistema pectinolítico produzido pelo fungo Paecilomyces variotii: produção, purificação e caracterização bioquímica de uma poligalacturonase. 2008. 125f. Dissertação (Mestrado) - Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (05/56999-0)
ZUBIETA, Mariane Paludetti. Aspergillus nidulans as a model to manipulate unfolded protein response-related genes : Aspergillus nidulans como modelo para manipulação de genes envolvidos no processo de unfolded protein response. 2018. Tese (Doutorado) – Universidade Estadual de Campinas, Instituto de Biologia. (14/15403-6)
CALZADO, Felipe. Análise comparativa do mecanismo de secreção de proteínas heterólogas em Aspergillus nidulans = Comparative analysis of the heterologous protein secretion in Aspergillus nidulans. 2017. Dissertação (Mestrado) - (14/23051-2)