CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
André Damasio is an Associate Professor in the Department of Biochemistry and Tissue Biology at the Institute of Biology at UNICAMP, where he founded the Laboratory of Enzymology and Molecular Biology of Microorganisms (LEBIMO). Graduated in Industrial Pharmacy (2005), he obtained the title of Doctor in Biochemistry (2011) with an emphasis in Biochemistry of Microorganisms at the Faculty of Medicine of Ribeirão Preto - USP. Part of the PhD was held at the Department of Microbiology and Molecular Genetics at Oklahoma State University, OK, USA (2009), where he developed tools for producing heterologous proteins in Aspergillus. Also, in 2010, he held part of the PhD at the Institute of Catalysis and Petrochemistry / CSIC, Madrid, Spain, where he applied techniques of immobilization and stabilization in target enzymes. In 2011, he joined the National Laboratory of Bioethanol Science and Technology (CTBE), Campinas-SP, initially as a Post-Doctorate (2011-2013) and then as a FAPESP Young Researcher (2013-2015). His research group is dedicated to studying "microbial biomanufacturing", mainly the production of recombinant proteins. Currently coordinates a FAPESP Thematic Grant whose main objective will be to establish a filamentous fungus strain for the production of different recombinant proteins such as Carbohydrate-active enzymes (CAZymes), Plastic-active enzymes (PAZymes), and Alternative Proteins in the context of the food industry. Moreover, LEBIMO is also part of The Brazilian National Institute of Science and Technology in Human Pathogenic Fungi (INCT-FUNVIR), where we contribute studying relationship between acylation of proteins and fungal virulence. (Source: Lattes Curriculum)
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With increasing demands for foods that have a lower environmental impact, are healthy, and have no animal origin, precision fermentation is a powerful tool to meet these requirements. Filamentous fungi traditionally used in industry for producing various food ingredients can also be utilized as a chassis for the heterologous production of alternative proteins. When strains are developed i…
Filamentous fungi are capable of producing and secreting a variety of enzymes. Aspergillus sp. and Trichoderma sp. are the major fungal cell factories for industrial enzyme production. Aspergillus oryzae is recognized as GRAS (generally regarded as a safe organism) and has the ability to secrete a high titer of proteins. Therefore, A. oryzae has been used as a low-cost microbial cell fact…
In the past few years, invasive fungal infections have been among the major causes of mortality and morbidity in immunocompromised individuals. One and a half million deaths are estimated per year, being the Aspergillus fumigatus the main invasive aspergillosis agent. Characteristics such as morphogenetic changes, host adaptation, and antifungals resistance contribute to the fungus virule…
Considering the entire conversion of plant biomass into bioproducts, such as the ethanol obtained from sugarcane bagasse (E2G), the enzymes make up a significant percentage of overall cellulosic ethanol production costs, ranging from 28% for off-site production to 22% for on-site and 10% for integrated enzyme production. The global market for industrial enzymes is expected to reach nearly…
(Only some records are available in English at this moment)
Given the growing environmental concerns, it is essential to seek alternatives to current production models. Precision fermentation emerges as a promising solution, utilizing natural resources to produce a variety of compounds, including proteins. Filamentous fungi, such as Aspergillus oryzae, are natural biofactories that, through genetic engineering, can be optimized to produce various …
Diseases caused by fungi cause approximately 1.5 million deaths every year, affecting mainly immunocompromised patients. The Aspergillus fumigatus species is responsible for a large proportion of serious infections such as Invasive Aspergillosis (IA). Current treatment options are limited and a large number of cases of antifungal resistance have been reported, so finding new targets and i…
Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that perform an oxidative cleavage of glycosidic bonds. The uncommon and remarkable LPMOs' active site is composed of a single copper atom coordinated by three nitrogen ligands, a structural motif known as histidine brace. The nitrogen ligands are provided by the amino group and side chain of an N-terminal His, and a…
(Only some records are available in English at this moment)
To reduce the use of current technologies employing fossil raw materials, many efforts are being made to use renewable energy through the biorefinery model. The main raw material in biorefineries is the lignocellulosic biomass, which can be converted into high added value products. The main constituents of the plant cell walls of these biomasses are cellulose, hemicellulose and lignin whi…
In the past few years, invasive fungal infections have been among the major causes of mortality and morbidity in immunocompromised individuals. One and a half million deaths are estimated per year, being the Aspergillus fumigatus the main invasive Aspergillosis agent. Characteristics such as morphogenetic changes, host adaptation, and antifungals resistance contribute to the fungus virule…
(Only some records are available in English at this moment)
Filamentous fungi exhibit immense potential as a source of industrially important enzymes, particularly hydrolytic enzymes, which play a crucial role in the production of biofuels and other bioproducts. Despite their exceptional capacity for protein secretion, there is still room for improvement in recombinant protein production. Therefore, it is vital to identify new genetic targets that…
A. fumigatus is an opportunistic pathogenic fungus that infects immunosuppressed patients. It has a high mortality rate due in part to difficulties in diagnosing fungal infections and the emergence of antifungal-resistant strains. Understanding the biology of this fungus by applying genetic engineering and bioinformatics is fundamental to comprehending the function of new genes and findin…
The knowledge on the enzymatic degradation of polysaccharides advanced in the last decade mainly due to the identification of lytic polysaccharide monooxygenases (LPMOs), metalloenzymes that potentiate the enzymatic conversion of lignocellulose, breaking down the cellulose crystallinity throughout an oxidative mechanism. Recently, the application of these enzymes has been demonstrated to …
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 9 / 6 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 18 / 17 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 43 / 39 | All research grants and scholarships |
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