Graduated in Biomedicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1996), Master's (1999) and Ph.D. in psychobiology from Universidade Federal de São Paulo (2004) and Postdoctoral from Emory University (2010). Currently, Associate Professor and head of the Sleep Division at Universidade Federal de São Paulo. President of the National Council for Control on Animal Experimentation (Brazilian Ministry of Science and Technology since 2015). In 2010, she was invited to be a Visiting Associate Professor at the Division of Neuropharmacology and Neurologic Disease (Yerkes National Primate Research Center, Emory University). In 2012, was invited to be Visiting Professor at Harvard Medical School (New England Primate Research Center). Educational Director of the of Sleep Institute and Researcher from the national council for research (CNPQ). Coordinator of sleep laboratories for mice and rats in the Department of Psychobiology. Affiliated member of the Brazilian Academy of Sciences, Brazilian Society of Sleep and World Association of Sleep Medicine. Reviewer on more than 80 international journals and a board member of the journal Sleep, Journal of Sexual Medicine among others; and Chief Editor of Sleep Science. In 2007, she was awarded on Women in Science program by Loreal/Brazilian Academy of Sciences and UNESCO. Published over 600 papers in international scientific journals, and author of 8 books and more than 50 chapters. She has experience in Psychobiology and she is working on the following topics: sleep deprivation, endocrine regulation, sexual behavior, neurotransmission, neurobiology of drug abuse, pain mechanisms, sleep monitoring in rodents and ethical principles of animal research. (Source: Lattes Curriculum)
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To assess the trilateral relationship between obstructive sleep apnea (OSA), erectile dysfunction (ED) and male fertility potential. Method: With this goal, the project proposes 5 sub-studies. Seventy-one men between 18 and 60 years old will be recruited for each of the 4 groups, resulting in 284 volunteers total, being the groups: 1) Without OSA and without ED; 2) With OSA and without ED…
Poor sleep quality is closely linked to comorbidities in several organic systems. Among sleep disorders, there has been a recent increase in the prevalence of obstructive sleep apnea (OSA) in the population, especially in men. The intermittent hypoxia resulting from OSA can produce physiopathological symptoms, including the impairment of reproductive function, especially in relation to er…
Leishmania is the protozoan responsible for leishmaniasis, a neglected disease that in Brazil causes about 100,000 new cases per year. In its life cycle, the parasite is found in the midgut of an insect or inside the phagolysosome in the macrophage of the mammalian host. The different stages of parasite life cycle influence the regulation of gene expression, which occurs at post-transcrip…
Chronic kidney disease (CKD) is a disease with high morbidity and mortality, whose incidence and prevalence have increased in epidemic proportions in Brazil and worldwide. Patients with CKD on dialysis are driven to live every day with an incurable disease that requires a long painful treatment with high-impact changes in their quality of life. Along with the evolution of the disease and …
(Only some records are available in English at this moment)
Change in sleep pattern is a condition with implications for public health. Studies have shownthat the intestinal microbiota has a constant and bidirectional connection with the brainthrough the brain-gut-microbiota axis, which is related to the tryptophan pathways, aprecursor of serotonin and, consequently, melatonin (sleep-regulating hormone).Inflammatory bowel diseases (IBD), whose pre…
Objective: To assess the trilateral relationship between obstructive sleep apnea (OSA), erectile dysfunction (ED) and male fertility potential. Method: With this goal, the project proposes 5 sub-studies. Seventy-one men between 18 and 60 years old will be recruited for each of the 4 groups, resulting in 284 volunteers total, being the groups: 1) Without OSA and without ED; 2) With OSA and…
The COVID-19 pandemic has brought several changes in the world scenario, covering not only the scope of public health, but also the economic and social ones. Health professionals have faced changes related to routine restructuring, insecurities and fears about the spread of the virus, long working hours and the lack of protective equipment in the hospital environment. In view of these con…
Sleep disorders are common in the general population, resulting in great repercussions and public expenditure. Among them, insomnia is one of the most important and has strong negative impacts on physical and mental health, especially in women. Currently, a pharmacological approach is the main treatment for insomnia. However, the search for alternative therapies has increased in the past …
(Only some records are available in English at this moment)
The first experiments that demonstrated the importance of the balance between T helper 1 (Th1) and T helper 2 (Th2) were conducted in experimental models of murine leishmaniasis. After the inoculation of a higher number of Leishmania major parasites, some mice strains proved to be resistant, as observed in C57BL/6 strain, and others develop lesions and even systemic disease, as in BALB/c …
Drug addiction is a chronic relapsing disorder which currently represents a global public health concern. Despite decades of research, there is no cure for drug abuse to date, mainly due to the heterogeneity of this disease and all the factors influencing it. Among them, one of the major clinical complaints reported by drug users is sleep impairment, which per se can worsen the course of …
We will explore the hypothesis that sleep loss induces cellular damage, leading to up-regulation of inflammatory markers, down-regulation of lipid transport pathways and up-regulation of fatty acid and triglyceride synthesis, favoring cardiometabolic diseases. Pharmacological approach will be used to investigate the role of the NLRP3 and LXR activation and inactivation on the inflammatory…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 7 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 38 / 32 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 52 / 44 | All research grants and scholarships |
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CV Lattes
ORCID