Patricia Palmeira Daenekas Jorge

• Abstract

  The availability of a panel of protein or genetic biomarkers that can differentiate sepsis from Systemic Inflammatory Response Syndrome (SIRS) earlier and also identify different response patterns caused by different etiological agents, may cause significant impact on morbidity and mortality of neonatal sepsis, contributing to the reduction of hospital costs and also differentiate a good …

  STUDY OF PROTEIN BIOMARKERS AND GENE EXPRESSION PROFILE OF NF-˜B PATHWAY IN LATE-ONSET NEONATAL SEPSIS: POTENTIAL VALUE IN DIAGNOSIS AND PROGNOSIS, AP.R

• Abstract

  The immaturity of the neonatal immune system has been suggested as the underlying factor for the susceptibility to infections e for the high rate of morbidity and mortality observed in this period. An efficient neonatal T-cell response requires the activation of antigen-presenting cells (APCs), which is triggered upon Toll-like receptors (TLRs) stimulation in response to their respective …

  Evaluation of the neonatal immune response: basic mechanisms of activation via Toll-like receptors 2 and 4 (TLR-2 and 4) in different antigen presenting cells from healthy term and preterm newborns and with early and late onset sepsis, AP.R
• Passive acquisition of protective antibodies reactive with bordetella pertussis by the newborn via placental transfer and breast-feeding., AR.EXT

(Only some records are available in English at this moment)

• Abstract

  The agent called "Severe Acute Respiratory Syndrome Coronavirus-2" (SARS-CoV-2) and its associated disease, "Coronavirus Disease 2019" (COVID-19) has affected children and adolescents, with an incidence ranging from 1.2% to 2%. Autopsies performed on schoolchildren and adolescents who acquired COVID-19 revealed lesions in multiple organs. In COVID-19 survivors, persistent inflammation may…

  Metabolomics analysis in schoolchildren and adolescents with COVID-19 treated at HCFMUSP, BP.DR

• Abstract

  Children and adolescents post-infection with SARS-COV-2 may have persistent inflammation, with isolated or concomitant attacks on various organs and systems, including the immune system. The over activation of the different compartments of the immune system during infection can interfere with the pattern of immune response of these individuals throughout their lives. However, to date, the…

  Assessment of soluble TREM-1 levels in pediatric patients with COVID-19 and post-infection with the SARS-COV-2 virus treated at HC-FMUSP, BP.IC

• Abstract

  Due to an "immunological inexperience", the sensitivity of newborns to infectious diseases might be partially due to the lack of pre-existing immunological memory in newborns. After birth, T and B lymphocytes usually undergo a massive expansion in healthy newborns at term, probably due to an extensive antigenic stimulation from the environment. In preterm newborns, it is presumed that the…

  Phenotypic characterization of T regulatory cell population in cord blood of term and preterm newborns, BP.MS