CV Lattes
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1983), master's at Biochemistry from Universidade de São Paulo (1986) and doctorate at Biochemistry from Universidade de São Paulo (1988). Has experience in Immunology, focusing on Imunogenetics, acting on the following subjects: microarrays, transcriptoma, cluster and tree view, expressão gênica and timo. (Source: Lattes Curriculum)
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The Autoimmune regulator (Aire) gene located on the human chromosome 21q22.3 or on mouse (Mus musculus) 10qC1, is a controller of the central immune tolerance and consequently the onset of autoimmune diseases. Aire share ~ 80% human-mouse similarity and it regulates the transcription of genes that encode peripheral tissue antigens (PTAs) in medullary thymic epithelial cells (mTECs) (promi…
The thymus plays a role in the induction of immunological tolerance to tissue related antigens (TRA). Within the thymic medulla, the medullary thymic epithelial cells (mTECs) express hundreds of these TRAs, which, in turn, represent virtually all organs and tissues of the body. Due to the diversity of representation, this phenomenon was called promiscuous gene expression (PGE) which is la…
Molecular genetic studies will be performed on type-1 (T1-D), type-2 (T2-D) and gestational (GD) diabetes, evaluating the large scale gene expression profiles (transcriptome level). T1-D is an autoimmune disorder caused by the immunological destruction of pancreatic β- cells, leading to insulin dependence. Although several susceptibility loci have been described in association with T1-D,…
The Transcriptome project is included in the field of functional genomics, i.e., the meaning of the DNA sequence function at the genomic level. Although much has been known in terms of human and non-human genomic DNA or cDNA sequencing data, few studies have been conducted on the function of these genes. The wide scale gene expression evaluation is the first step on the understanding of f…
The post-doc fellow will study the effect of mutations in the Aire gene, associated with the APS1 syndrome, on two of the essential processes of mTEC cells during the induction of central immunological tolerance in the thymus, that is, the thymocyte migration - mTECs, which is necessary for adhesion to occur between these cells. Also, we will assess whether these mutations influence the t…
The fellow will study the transcriptional profile involving mRNAs and miRNAs of thymocytes that physically interact with Aire wild-type (wt) or Aire mutant mTECs cells (adhesion mTECs-thymocytes in vitro). As discussed in the thematic project, the interaction between thymocytes and epithelial thymic cells (TECs) is essential for the development of these two cell types. To test this hypoth…
The IC fellow will work with the graduate and post-doctoral students of the thematic project under supervision. She will use the CRISPR-Cas9 system to induce mutations in the Aire gene, in mTEC cells line 3.10, the same mutations that are associated with the APS1 syndrome. We will make the selection of the mutations of the human Aire gene (SAND and PHD domains) to design the guide RNA (gR…
The Autoimmune regulator (Aire) gene (human chromosome 21q22.3 and Mus musculus 10qC1), is a controller of central immune tolerance and the emergence of autoimmune diseases. The Aire sequence presents ~ 80% man-mouse similarity and this gene regulates the transcription of peripheral tissue autoantigen genes (PTAs) in medullary thymic epithelial cells (mTECs). This phenomenon was termed pr…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 10 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 31 / 5 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 45 / 11 | All research grants and scholarships |
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