Post-doctorate at the University of Gothenburg, Department of Clinical Neurosciences and Physiology, Sahlgrenska Academy, Sweden (2014) and State University of Campinas (UNICAMP) (2015); Master (2006) and PhD (2009) in Cellular and Structural Biology (UNICAMP - CAPES 6), with emphasis in Tissue Biology. Develops projects mainly in the field of Pharmacology, focusing on translational research, specifically on the development of immunomodulatory drugs with therapeutic potential in inflammatory, neurodegenerative, autoimmune and cancer diseases. It has experience in microscopic, morphophysiological and molecular analyzes of cells and tissues. It is a member of the editorial board/reviewer of 17 international Journals and is a reviewer of Elsevier. It has 2 chapters of books and 20 articles published in international journals. Currently it is coordinator of projects funded by the Brazilian Foundations, FAPESP (2015/04194-0) and CNPq (431465/2016-9), including research grants and scholarships (Project: Identification of new molecules with chemotherapeutic effect in glioma and characterization of its mechanism of action). Supervises 2 PhD's, 4 master's degrees, and 2 undergraduate students, and 1 technical training. (Source: Lattes Curriculum)
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I. Overview: The use of products of natural origin is considered strategic in the context of cancer treatment. It was recently demonstrated that components of the venom of the Phoneutria nigriventer (PnV) spider have antitumor effects in vitro and in vivo models, with emphasis on the modulation of the immune response against glioblastomas. Recently, the composition containing dendritic ce…
Malignant brain tumors are among the most devastating types of human cancer. The ability to invade healthy neural tissue is a characteristic of gliomas that makes the treatment difficult. The PI3K/Akt/mTOR (and the PTEN phosphatasis, which innactivates that pathway) and RhoA/ROCK pathways and the Na+/K+-ATPase pump are involved in the tumorigenesis, migration, invasion, growth and surviva…
Severe accidents caused by the "armed" spider Phoneutria nigriventer causeneurotoxic manifestations in victims. In experiments with rats, P. nigriventer venom(PNV) temporarily disrupts the properties of the blood brain barrier (BBB) by affecting both the transcellularand the paracellular route. However, it is unclear how cells and/or proteins participatein the transient opening of the BBB…
Gliomas correspond to approximately 80% of primary malignant brain tumors in adults. Until recently, these tumors were classified mainly on the basis of histopathological criteria; however, associating these aspects to the identification of the molecular profile of the neoplasias has been shown to be a more accurate strategy in relation to the prediction of the tumor's behavior and its re…
Immuno-oncology is an emerging field that is revolutionizing the treatment of cancer. Although most immunomodulatory strategies have focused on increasing T cell response, there has been a recent increase in the interest in the natural killer (NK) cell compartment. Clinical responses to NK cell-based adoptive immunotherapy, however, were thwarted by the profound immunosuppression induced …
Gliomas account for approximately 80% of primary malignant brain tumors in adults. The highly infiltrating and aggressive glioblastoma subtype (grade IV) corresponds to an average patient survival around 15 months after diagnosis. Advances in knowledge of new therapeutic options have not yet significantly improved the survival of these patients, who are currently treated using surgical re…
Cancer is a multifactorial disease, involving a complex mechanism. In the last decade, the evasion of the immune response has been recognized as an important feature of tumor development. Since the immune system is responsible for recognizing and eliminating neoplastic cells, the development of solid tumors would therefore occur through a failure in that system. On the other hand, it has …
Animal venoms are a mixture of biologically active molecules with specific targets in cells and tissues. These molecules may be useful for investigating pathophysiological mechanisms, and serve as a prototype for the development of new drugs. Our group recently demonstrated that astrocytes are directly targeted by molecules present in the Phoneutria nigriventer spider venom (PNV) (Ctenida…
(Only some records are available in English at this moment)
Gamma delta T cells hold great promise for cancer immunotherapy, as they display broad tumor reactivity, and recognize tumor cells independently of both mutational load and human leukocyte antigen (HLA)-mediated antigen presentation. Our laboratory has established a clinical-grade protocol allowing robust expansion and differentiation of anti-tumor V delta 1+ T cells (termed Delta One T/ …
Parkinson's disease (PD) is a neurodegenerative condition that affects the Central Nervous System. It is an idiopathic degeneration and touches about 1% of the elderly population over the age of 60 worldwide. As the epidemiological profile of the population is changing, with a large increase in the number of elderly people, PD is also more common and research to understand the condition a…
Immunomodulation has been considered an established antitumor approach, since immune cells, mainly macrophages, are involved in tumorigenesis. The tumor microenvironment infiltrating cells include regulatory lymphocytes and myeloid cells, represented by different populations of macrophages known as tumor-associated macrophages (TAMs). Although they show a complex phenotypic and behavioral…
(Only some records are available in English at this moment)
| 2 / 1 | Ongoing research grants |
| 4 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 21 / 17 | All research grants and scholarships |
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CV Lattes
ORCID