CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences (1977) and Ph.D. in Biochemistry (1981) by the Universidade de São Paulo. Postdoctoral fellow at the Institute Pasteur, Paris (1981-83) and at the EMBL Heidelberg, Germany (1983). He became Assistant Professor at the Universidade Federal de São Paulo (1984) and joined the New York University Medial Center (1988-91). In 1997 he became Full Professor of Microbiology at the Federal University of São Paulo, Brazil. He is currently member of the Editorial board of Microbes and Infection, Cellular Microbiology, and Protein and Peptide Letters. His research is in the area of Molecular and Cell Biology of Trypanosomes with focus on studies of sialidases, gene expression regulation, protein synthesis, and nucleus organization. At the present, it participate in the Center for Research, Innovation and Diffusion about antimicrobial resistance (ARIES) (Source: Lattes Curriculum)
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Spatial biology encompasses a variey of technological techniques that are used to investigate the influence of the microenvironment on cellular dynamics in different contexts. One of these approaches is the laser microscopy, which enables the simultaneous analysis of several proteins in fixed material or in living cells, enabling in situ observation of cellular dynamics at the molecular l…
This project is for the acquisition of a scanning electron microscopy system with 3D reconstruction system. This system is unique in Latin America and allows analyzing different types of biological specimens (tissues and cells) and doing three-dimensional reconstructions, since it has a built-in ultramicrotome. It will also continue to scan conventional high resolution (up to 2 nm), which…
Antimicrobial resistance (AMR) has been considered one of the main threats to the human race in the 21st century. We are facing an unstoppable fast-forward instance of Darwinian adaptation through natural selection, in which microbes are constantly evolving to survive antimicrobials. As part of their natural behavior, they adapt continuously. They will succeed unless we develop effective …
(Only some records are available in English at this moment)
Protozoan parasites, which are major human pathogens in both Brazil and Israel, were shown to release extracellular vesicles (EVs) into the host microenvironment, and these are known to modulate the intracellular communication between pathogens and hosts. Although these EVs have been characterized and shown to play important roles in the establishment of infection, specific processes invo…
Response mechanisms of protozoan parasites to the situations found in the hosts is not well known. This understanding can help to identify new chemotherapeutic targets and on the comprehension of the mechanisms that lead to pathogenesis. Our group has studied for last several years, how protein synthesis is regulated in Trypanosoma under stressing conditions. In this thematic project, we …
(Only some records are available in English at this moment)
Cholesterol is the main component of the plasma membrane in most eukaryotes. Some fungi and parasites, despite not synthesizing cholesterol as a membrane ester, but rather ergosterol, uptake cholesterol from the environment and use it for their metabolism. In Candida albicans and Nakaseomyces glabratus, mechanisms for the uptake of cholesterol from the host serum have already been descr…
(Only some records are available in English at this moment)
In the one-and-a-half-month internship, the student will learn how to isolate, identify, and determine antimicrobial susceptibility from foodborne bacteria. Resistant and susceptible bacteria will be isolated and their resistance will be characterized by microbiological methods. Then, analyses of the metabolic composition of selected susceptible and resistant bacteria will be used in the …
Antimicrobial resistance (AMR) is a global public health problem. The rapid spread of multidrug-resistant bacterial pathogens threatens the ability to treat infections, as the available therapeutic options are significantly reduced. Currently, the fight against AMR is through concepts of Global Health and One Health, with the environment as one of the main disseminators of antimicrobial-r…
The rapid spread of antimicrobial-resistant bacteria has become a global public health problem. Although antimicrobial resistance (AMR) receives greater attention in hospitals, its dissemination and evolution in the environment has gained notoriety. The environment is considered a reservoir and disseminator of antimicrobial-resistant bacteria and antimicrobial resistance genes. Furthermor…
(Only some records are available in English at this moment)
Lysine acetylation has emerged as a major post-translational modification involved in diverse cellular functions in higher eukaryotes. While histone proteins are the founding members of lysine acetylation substrates, it is now clear that hundreds of other proteins can be acetylated in multiple compartments of the cell. During its life cycle the Trypanosoma cruzi face different environment…
| 4 / 4 | Ongoing grants |
| 19 / 18 | Completed research grants |
| 10 / 10 | Ongoing scholarships in Brazil |
| 57 / 21 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 91 / 54 | All research grants and scholarships |
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