CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences (1977) and Ph.D. in Biochemistry (1981) by the Universidade de São Paulo. Postdoctoral fellow at the Institute Pasteur, Paris (1981-83) and at the EMBL Heidelberg, Germany (1983). He became Assistant Professor at the Universidade Federal de São Paulo (1984) and joined the New York University Medial Center (1988-91). In 1997 he became Full Professor of Microbiology at the Federal University of São Paulo, Brazil. He is currently member of the Editorial board of Microbes and Infection, Cellular Microbiology, and Protein and Peptide Letters. His research is in the area of Molecular and Cell Biology of Trypanosomes with focus on studies of sialidases, gene expression regulation and nucleus organization. (Source: Lattes Curriculum)
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Parasitic protozoa of Trypanosoma and Leishmania species, respectively agents of Chagas disease and leishmaniasis, control their gene expression mainly through post-translational mechanisms. This is due to the selection of mRNAs that will be translated in each environment in which the parasites are located. During the passage from one host to another, changes occur in the availability of …
Protozoan parasites, which are major human pathogens in both Brazil and Israel, were shown to release extracellular vesicles (EVs) into the host microenvironment, and these are known to modulate the intracellular communication between pathogens and hosts. Although these EVs have been characterized and shown to play important roles in the establishment of infection, specific processes invo…
Response mechanisms of protozoan parasites to the situations found in the hosts is not well known. This understanding can help to identify new chemotherapeutic targets and on the comprehension of the mechanisms that lead to pathogenesis. Our group has studied for last several years, how protein synthesis is regulated in Trypanosoma under stressing conditions. In this thematic project, we …
The surface of protozoan parasites represents the interface with the host, and plays roles in invasion, immune evasion, signaling, and more. We recently identified a conserved ubiquitylation pathway in African trypanosomes that controls the surface copy number of important trans-membrane domain proteins, and which provides a means for the first time to manipulate trans-membrane domain pro…
(Only some records are available in English at this moment)
The Trypanosoma cruzi is a flagellate protozoon that cause of Chagas disease in man. In its life cycle, T. cruzi presents a high capacity of environmental adaptation. However, the mechanisms that signal this adaptation are not yet well known. It possibly depends on the availability of nutrients. One of the main mechanisms involved in the control of the energy state of eukaryotes cells occ…
The present PhD project, entitled "Characterization of TcCyp19 and evaluation of its role during the cellular infection by Trypanosoma cruzi", was initiated by the joint work of Prof. Sergio Schenkman with Prof. Bradford Mcgwire of Ohio University who initiated studies showing the expression of cyclophilin 19 (TcCyp 19) in T. cruzi, the protozoan parasite that causes Chagas' disease. They…
Considering the similarity of Cyclophilin 19, T. cruzi with human Cyclophilin A, and the already consolidated literature regarding the role of CyPA in inflammatory processes and in various heart diseases, this project aims to verify if cyclophilin 19 is expressed in the forms of T. cruzi that are in contact with mammalian cells have some effect on cellular responses and thus determine whe…
(Only some records are available in English at this moment)
Lysine acetylation has emerged as a major post-translational modification involved in diverse cellular functions in higher eukaryotes. While histone proteins are the founding members of lysine acetylation substrates, it is now clear that hundreds of other proteins can be acetylated in multiple compartments of the cell. During its life cycle the Trypanosoma cruzi face different environment…
| 2 / 2 | Ongoing research grants |
| 18 / 17 | Completed research grants |
| 48 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 69 / 32 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 26 |
| Citations | 115 |
| Cit./Article | 4.4 |
| Data from Web of Science | |
MALVEZZI, AMARANTA MUNIZ; ARICO, MIRELLA; SOUZA-MELO, NORMANDA; DOS SANTOS, GREGORY PEDROSO; BITTENCOURT-CUNHA, PAULA; HOLETZ, FABIOLA BARBIERI; SCHENKMAN, SERGIO. GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 10, APR 16 2020. Web of Science Citations: 2. (18/07766-2, 17/02416-0)
AVILA, CARLA CRISTI D. C.; PEACOCK, LORI; MACHADO, FABRICIO CASTRO; GIBSON, WENDY; SCHENKMAN, SERGIO; CARRINGTON, MARK; CASTILHO, BEATRIZ A.. Phosphorylation of eIF2 alpha on Threonine 169 is not required for Trypanosoma brucei cell cycle arrest during differentiation. Molecular and Biochemical Parasitology, v. 205, n. 1-2, p. 16-21, JAN-FEB 2016. Web of Science Citations: 2. (09/52047-5, 11/51973-3)
MORETTI, NILMAR SILVIO; AUGUSTO, LEONARDO DA SILVA; CLEMENTE, TATIANA MORDENTE; PINTO ANTUNES, RAYSA PAES; YOSHIDA, NOBUKO; TORRECILHAS, ANA CLAUDIA; NOGUEIRA CANO, MARIA ISABEL; SCHENKMAN, SERGIO. Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease. Antimicrobial Agents and Chemotherapy, v. 59, n. 8, p. 4669-4679, AUG 2015. Web of Science Citations: 15. (11/51973-3)
PASCOALINO, BRUNO; DINDAR, GUELCIN; VIEIRA-DA-ROCHA, JOAO P.; MACHADO, CARLOS RENATO; JANZEN, CHRISTIAN J.; SCHENKMAN, SERGIO. Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei. Nucleic Acids Research, v. 42, n. 5, p. 2906-2918, MAR 2014. Web of Science Citations: 9. (11/51973-3)
ROCHA, ANTONIO AUGUSTO; MORETTI, NILMAR SILVIO; SCHENKMAN, SERGIO. Stress Induces Changes in the Phosphorylation of Trypanosoma cruzi RNA Polymerase II, Affecting Its Association with Chromatin and RNA Processing. Eukaryotic Cell, v. 13, n. 7, p. 855-865, JUL 2014. Web of Science Citations: 2. (11/51973-3)
PRATA RAMOS, THIAGO CESAR; NUNES, VINICIUS SANTANA; NARDELLI, SHEILA CRISTINA; PASCOALINO, BRUNO DOS SANTOS; MORETTI, NILMAR SILVIO; ROCHA, ANTONIO AUGUSTO; AUGUSTO, LEONARDO DA SILVA; SCHENKMAN, SERGIO. Expression of non-acetylatable lysines 10 and 14 of histone H4 impairs transcription and replication in Trypanosoma cruzi. Molecular and Biochemical Parasitology, v. 204, n. 1, p. 1-10, NOV 2015. Web of Science Citations: 8. (11/51973-3)
PHAN, ISABELLE Q. H.; DAVIES, DOUGLAS R.; MORETTI, NILMAR SILVIO; SHANMUGAM, DHANASEKARAN; CESTARI, IGOR; ANUPAMA, ATASHI; FAIRMAN, JAMES W.; EDWARDS, THOMAS E.; STUART, KENNETH; SCHENKMAN, SERGIO; et al. Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 71, n. 5, SI, p. 615-621, MAY 2015. Web of Science Citations: 6. (13/20074-9, 11/51973-3)
CAMPOS, I. T. N.; SOUZA, T. A. C. B.; TORQUATO, R. J. S.; DE MARCO, R.; TANAKA-AZEVEDO, A. M.; TANAKA, A. S.; BARBOSA, J. A. R. G.. The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, v. 68, n. 6, p. 695-702, JUN 2012. Web of Science Citations: 16. (01/07535-0, 05/03514-9)
COSTA, F. C.; OLIVA, M. A. V.; DE JESUS, T. C. L.; SCHENKMAN, S.; THIEMANN, O. H.. Oxidative stress protection of Trypanosomes requires selenophosphate synthase. Molecular and Biochemical Parasitology, v. 180, n. 1, p. 47-50, NOV 2011. Web of Science Citations: 8. (98/14138-2, 99/02874-9, 07/54621-5)
LEITE, ARIELY BARBOSA; SEVERO GOMES, ANTONIEL AUGUSTO; DE CASTRO NASCIMENTO SOUSA, ANA CAROLINE; DE MATTOS FONTES, MARCOS ROBERTO; SCHENKMAN, SERGIO; MORETTI, NILMAR SILVIO. Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity. Biochemical Journal, v. 477, n. 9, p. 1733-1744, MAY 2020. Web of Science Citations: 0. (18/09948-0, 15/22031-0)
DOS SANTOS, GREGORY PEDROSO; ABUKAWA, FERNANDA MIDORI; SOUZA-MELO, NORMANDA; ALCANTARA, LAURA MARIA; BITTENCOURT-CUNHA, PAULA; MORAES, CAROLINA BORSOI; JHA, BIJAY KUMAR; MCGWIRE, BRADFORD S.; MORETTI, NILMAR SILVIO; SCHENKMAN, SERGIO. Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth. Cellular Microbiology, v. 23, n. 4, DEC 2020. Web of Science Citations: 0. (18/09948-0, 17/02416-0, 17/19303-4, 18/07766-2)
MACHADO, FABRICIO CASTRO; FRANCO, CAIO HADDAD; DOS SANTOS NETO, JOSE VITORINO; DIAS-TEIXEIRA, KARINA LUIZA; MORAES, CAROLINA BORSOI; LOPES, ULISSES GAZOS; AKTAS, BERTAL HUSEYIN; SCHENKMAN, SERGIO. Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation. SCIENTIFIC REPORTS, v. 8, MAR 20 2018. Web of Science Citations: 1. (14/01577-2)
MOREIRA, DOUGLAS DE SOUZA; DUARTE, ANA PAULA; MIRSKY PAIS, FABIANO SVIATOPOLK; DA SILVA-PEREIRA, ROSIANE APARECIDA; ROMANHA, ALVARO JOSE; SCHENKMAN, SERGIO; FONSECA MURTA, SILVANE MARIA. Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations. Memórias do Instituto Oswaldo Cruz, v. 113, n. 9, 2018. Web of Science Citations: 0. (15/22031-0)
COSTA CATTA-PRETA, CAROLINA MOURA; PASCOALINO, BRUNO DOS SANTOS; DE SOUZA, WANDERLEY; MOTTRAM, JEREMY C.; MOTTA, MARIA CRISTINA M.; SCHENKMAN, SERGIO. Reduction of Tubulin Expression in Angomonas deanei by RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium. Journal of Eukaryotic Microbiology, v. 63, n. 6, p. 794-803, NOV-DEC 2016. Web of Science Citations: 2. (11/51973-3)
DE LIMA STEIN, MARIANA LEDO; ICIMOTO, MARCELO YUDI; DE CASTRO LEVATTI, ERICA VALADARES; OLIVEIRA, VITOR; STRAUS, ANITA HILDA; SCHENKMAN, SERGIO. Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei. Molecular and Biochemical Parasitology, v. 214, p. 36-46, JUN 2017. Web of Science Citations: 2. (15/22031-0, 11/51973-3)
TORRECILHAS, ANA CLAUDIA; SOARES, RODRIGO PEDRO; SCHENKMAN, SERGIO; FERNANDEZ-PRADA, CHRISTOPHER; OLIVIER, MARTIN. Extracellular Vesicles in Trypanosomatids: Host Cell Communication. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 10, DEC 14 2020. Web of Science Citations: 2. (19/15909-0)
MATUTINO BASTOS, TANIRA; BOTELHO PEREIRA SOARES, MILENA; HADDAD FRANCO, CAIO; ALCANTARA, LAURA; ANTONINI, LORENZO; SABATINO, MANUELA; MAUTONE, NICOLA; HOLANDA FREITAS-JUNIOR, LUCIO; MORAES, CAROLINA BORSOI; RAGNO, RINO; et al. Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 10, MAY 2020. Web of Science Citations: 0. (18/09948-0, 15/22031-0)
CASTRO MACHADO, FABRICIO; BITTENCOURT-CUNHA, PAULA; MALVEZZI, AMARANTA MUNIZ; ARICO, MIRELLA; RADIO, SANTIAGO; SMIRCICH, PABLO; ZOLTNER, MARTIN; FIELD, MARK C.; SCHENKMAN, SERGIO. EIF2 alpha phosphorylation is regulated in intracellular amastigotes for the generation of infectiveTrypanosoma cruzitrypomastigote forms. Cellular Microbiology, v. 22, n. 11, JUL 2020. Web of Science Citations: 0. (14/01577-2, 17/02496-4)
NUNES, VINICIUS SANTANA; MORETTI, NILMAR SILVIO; DA SILVA, MARCELO SANTOS; ELIAS, MARIA CAROLINA; JANZEN, CHRISTIAN J.; SCHENKMAN, SERGIO. Trimethylation of histone H3K76 by Dot1B enhances cell cycle progression after mitosis in Trypanosoma cruzi. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1867, n. 7, JUL 2020. Web of Science Citations: 0. (14/03714-7)
DE OLIVEIRA, VIVIAN CRISTINA; DE LACERDA, MARCELO PITOMBEIRA; MUNIZ MORAES, BARBARA BOMFIM; GOMES, CAIO PEREZ; MARICATO, JULIANA TERZI; SOUZA, OLIVIA FONSECA; SCHENKMAN, SERGIO; PESQUERO, JOAO BOSCO; MORETTI, NILMAR SILVIO; RODRIGUES, CELSO ARRAIS; et al. Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia. Journal of Leukocyte Biology, v. 106, n. 3, SI, p. 581-594, SEP 2019. Web of Science Citations: 0. (11/51973-3, 15/01986-2, 14/27198-8)
BASTOS, TANIRA MATUTINO; RUSSO, HELENA MANNOCHIO; MORETTI, NILMAR SILVIO; SCHENKMAN, SERGIO; MARCOURT, LAURENCE; GUPTA, MAHABIR PRASHAD; WOLFENDER, JEAN-LUC; QUEIROZ, EMERSON FERREIRA; PEREIRA SOARES, MILENA BOTELHO. Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins. Molecules, v. 24, n. 7, APR 3 2019. Web of Science Citations: 1. (18/09948-0, 15/22031-0)
LEANDRO DE JESUS, TERESA CRISTINA; NUNES, VINICIUS SANTANA; LOPES, MARIANA DE CAMARGO; MARTIL, DAIANA EVELIN; IWAI, LEO KEI; MORETTI, NILMAR SILVIO; MACHADO, FABRICIO CASTRO; DE LIMA-STEIN, MARIANA L.; THIEMANN, OTAVIO HENRIQUE; ELIAS, MARIA CAROLINA; et al. Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi. JOURNAL OF PROTEOME RESEARCH, v. 15, n. 6, p. 2039-2051, JUN 2016. Web of Science Citations: 12. (08/57910-0, 11/06087-5, 14/03714-7, 13/07467-1, 11/22619-7, 15/04867-4, 14/01577-2, 11/51973-3)
AUGUSTO, LEONARDO DA SILVA; MORETTI, NILMAR SILVIO; PRATA RAMOS, THIAGO CESAR; LEANDRO DE JESUS, TERESA CRISTINA; ZHANG, MIN; CASTILHO, BEATRIZ A.; SCHENKMAN, SERGIO. A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in Trypanosoma cruzi. PLOS PATHOGENS, v. 11, n. 2, FEB 2015. Web of Science Citations: 13. (12/50399-4, 09/52047-5, 11/51973-3)
ROUT, MICHAEL P.; OBADO, SAMSON O.; SCHENKMAN, SERGIO; FIELD, MARK C.. Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity. PLOS PATHOGENS, v. 13, n. 3, MAR 2017. Web of Science Citations: 3. (15/22031-0, 11/51973-3)
CESTARI, IGOR; HAAS, PAIGE; MORETTI, NILMAR SILVIO; SCHENKMAN, SERGIO; STUART, KEN. Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites. Cell Chemical Biology, v. 23, n. 5, p. 608-617, MAY 19 2016. Web of Science Citations: 7. (13/20074-9, 11/51973-3)
MORETTI, NILMAR SILVIO; CESTARI, IGOR; ANUPAMA, ATASHI; STUART, KEN; SCHENKMAN, SERGIO. Comparative Proteomic Analysis of Lysine Acetylation in Trypanosomes. JOURNAL OF PROTEOME RESEARCH, v. 17, n. 1, p. 374-385, JAN 2018. Web of Science Citations: 4. (13/20074-9, 15/22031-0, 11/51973-3)
GUIMARÃES, B. G.; MEDRANO, F. J.; TANAKA, APARECIDA SADAE; BARBOSA, J. A. R. G.. Crystallization, data collection and phasing of infestin 4, a factor XIIa inhibitor. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, v. 60, n. 11, p. 2051-2053, Nov. 2004. (01/07535-0)
FREITAS‚ L.H.G.; PORTO‚ R.M.; PIRRIT‚ L.A.; SCHENKMAN‚ S.; SCHERF‚ A.; OTHERS. Identification of the telomere in Trypanosoma cruzi reveals highly heterogeneous telomere lengths in different parasite strains. Nucleic Acids Research, v. 27, n. 12, p. 2451-2456, 1999. (97/01029-8)