Sandro Massao Hirabara
CV Lattes
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Universidade Cruzeiro do Sul (UNICSUL). Centro de Ciências Biológicas e da Saúde (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate in Biology at Universidade Federal do Paraná (2000), PhD in Science (Human Physiology) at University of São Paulo (2005), Post-doc at the University of Geneva (2007), and Visiting Scholar Scientist at Yale University (2019). He has experience in Physiology, with emphasis on Endocrine Physiology, Metabolism, and Exercise Physiology. He has expertise in the following subareas: fatty acids, insulin resistance, skeletal muscle metabolism, cell signaling, mitochondrial function and physical exercise. He also is a scientific adviser of FAPESP, editor and reviewer of important international journals. Nowadays, he acts as Titular Professor of the Interdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports (ICAFE), Cruzeiro do Sul University. (Source: Lattes Curriculum)
- Cellular and molecular mechanisms of insulin resistance and inflammation in obese Wistar rats and lean Goto-Kakizaki rats: causes and associations with diet and physical exercise, AP.TEM
Abstract
Peripheral Insulin Resistance (IR) and inflammation follow the development of Type 2 Diabetes Mellitus (DM2), with a high prevalence in obese patients. However, a significant percentage of non-obese individuals present DM2, especially in specific regions. For example, in Brazil, this percentage reaches 10 to 20%, while, in Japan, about 60% of type 2 diabetic patients have no Obesity. Th...
- Curtin University (Peth, Australia) and Cruzeiro do Sul University (Sao Paulo, Brazil): promoting collaborative research activities, AV.EXT
Abstract
The Prof. Dr. Philip Newsholme's visit will be important to discuss, direct, and strengthen actions for promoting collaborative academic-scientific activities among the research institutions of this proposal, as well as for contributing to the learning and establishment of new methodologies between Curtin University (Perth, Australia) and Brazilin research institutions from the Sao Paul...
- Characterization of epigenetics biomarkers of type 2 diabetes mellitus: identification of potential therapeutic targets of n-3 polyunsaturated fatty acids, AP.R
Abstract
MicroRNAs (miRNAs) are involved in the control of energy metabolism and development of chronic diseases, such as obesity, T2DM, and metabolic syndrome. The identification of miRNAs associated with T2DM development is essential to understand the syndrome etiology and direct futher therapeutic studies. This project aims to characterize the expression profile of circulating exosomal miRNAs...
- 1) glutamine supplementation stimulates protein-synthetic and inhibits protein- degradative... 2) sunflower oil supplementation has pro-inflammatory effects... 3) maternal moderate physical training during pregnancy attenuates., PUB.ART
Abstract
Inflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, and cardiovascular diseases. Various studies show a relationship between these two factors, although the mechanisms involved are not completely understood yet. Here, we discuss the molecular basis of insulin resistance and inflammation and th...
(Only some records are available in English at this moment)
- Metabolism of the brown adipose tissue in animal models of insulin resistance: Goto-Kakizaki and obese Wistar rats, BP.DD
Abstract
Overweight and obesity are related to several disorders, such as insulin resistance, chronic inflammation, Type 2 Diabetes Mellitus, cardiovascular diseases, dyslipidemia, metabolic syndrome, and cancer. Brown Adipose Tissue (BAT) has been proposed as a potential intervention for obesity because its high metabolic capacity to dissipate energy as heat without ATP synthesis, enhancing ene...
- Characterization of epigenetic biomarkers of type 2 diabetes mellitus: identification of potential therapeutic targets of n-3 polyunsaturated fatty acids, BP.TT
- MicroRNAs identification as potential targets of type 2 diabetes mellitus diagnostic and therapeutic, BP.PD
Abstract
MicroRNAs (miRNAs) are involved in the control of energy metabolism and development of chronic diseases, such as obesity, T2DM, and metabolic syndrome. The identification of miRNAs associated with T2DM development is essential to understand the syndrome etiology and direct futher therapeutic studies. This project aims to characterize the expression profile of circulating exosomal miRNAs...
- Effect of supplementation with omega-3 fatty acids, with or without practicing regular exercise, in insulin resistance and inflammation in mice subjected to a high fat diet, BP.IC
Abstract
Obesity is a major public health problem in both developed countries and in developing countries or poor. In Brazil about 40 % of the population is overweight and obesity is higher in females than in males. Obesity is an etiologic factor in chronic inflammation and consequently the organ dysfunction. Fatty acids have long chain carboxylic acids and, in general, all contain an even numbe...
(Only some records are available in English at this moment)
- BRITE/BEIGE adipocytes - a potential tool against obesity and diabetes?, BE.EP.DD
Abstract
Energy balance is defined by two components: energy intake and energy expenditure. Even minor but chronic perturbations in either of these two components can lead to an increase (obesity) or decrease in body weight. Obesity is not only a significant problem in itself but is also a major inducer of type 2 diabetes, cardiovascular disease and certain forms of cancer. At present there is n...
- Metabolic memory for atherosclerosis is mediated by epigenetic modifications in the bone marrow, BE.EP.PD
Abstract
Epigenetic modifications are one of the most important means for control of gene activity; in essence to store, retain, and recall past experiences in a way to shape present and future behaviour. Over the last decade we have characterised the key epigenetic changes imprinted following exposure to high glucose levels. In addition, we have shown that this epigenetic programming directly c...
- Effect of n-3 fatty acid supplementation on atrophy induced by hindlimb suspension and hypertrophy induced by reweighting in C57BL/6 mice fed a high-fat diet, BE.EP.DR
Abstract
Insulin resistance (IR) is observed in several conditions, including obesity, type 2 diabetes mellitus and metabolic syndrome. Under these conditions an increase in pro-inflammatory factors and oxidative stress has been observed, which may play an important role in activation of pathways related to skeletal muscle (ME) wasting (atrophy) and a shift toward fast twitch, glycolytic fibers,...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 8 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 26 / 22 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 2 |
| Citations | 112 |
| Cit./Article | 56.0 |
| Data from Web of Science | |
HIRABARA, SANDRO M.; CURI, RUI; MAECHLER, PIERRE. Saturated Fatty Acid-Induced Insulin Resistance Is Associated With Mitochondrial Dysfunction in Skeletal Muscle Cells. Journal of Cellular Physiology, v. 222, n. 1, p. 187-194, JAN 2010. Web of Science Citations: 96. (08/01177-3)
DA CUNHA DE SA, ROBERTA D. C.; CRISMA, AMANDA R.; CRUZ, MAYSA M.; MARTINS, AMANDA R.; MASI, LAUREANE N.; DO AMARAL, CATIA L.; CURI, R.; ALONSO-VALE, MARIA I. C.. Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes. JOURNAL OF PHYSIOLOGY-LONDON, v. 594, n. 21, p. 6301-6317, NOV 2016. Web of Science Citations: 16. (10/07596-8, 11/51627-8, 10/05669-8, 13/03268-4)
(References retrieved automatically from State of São Paulo Research Institutions)
MARTINS, Amanda Roque. Efeitos da suplementação com óleo de peixe sobre a resistência à insulina e a função mitocondrial no músculo esquelético de camundongos alimentados com dieta hiperlipídica.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/05669-8)
SOUSA, Luís Gustavo Oliveira de. Vias de síntese e degradação de proteínas na resistência à insulina induzida por dieta hiperlipídicas: efeito da suplementação com ácidos graxos ômega-3 e do treinamento físico aeróbico.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/18921-7)