BS in Chemistry from the University of Campinas (1987). Doctorate of Science (Organic Chemistry) - Universite Libre de Bruxelles (1992). Professional activities include: Development of processes in organic synthesis with the Technological Development Company (Codetec, 1987), Development of processes in Phytochemistry at the Center for Multidisciplinary Research Chemical, Biological and Agricultural UNICAMP (CPQBA, 1987-1988 and 1992-1993 ). Professor (1993-2001), Associate Tenured Professor (2001-2010) and Full Professor (since 2011) at the Institute of Chemistry of São Carlos (IQSC), University of São Paulo (USP). Conducted post-doctorate in the Department of Chemistry, University of British Columbia (Vancouver, Canada) between 1997 and 1998. It acts as a lecturer and researcher in organic chemistry. He is coordinator and leader of Organic Chemistry of Natural Products (GQOPN) registered at CNPq. Research projects in progress in their primary objective GQOPN the discovery of natural products with biological activity, with potential medical use, biochemistry, biological and agrochemical. Due to its interdisciplinary nature, research conducted by GQOPN is developed in collaboration with researchers at the Federal University of São Carlos (São Carlos-SP), National Museum, Federal University of Rio de Janeiro (Rio de Janeiro-RJ), University of Parana (Curitiba-PR), Federal University of Ceara (Fortaleza-CE), the Multidisciplinary Center for Chemical, Biological and Agricultural Unicamp (Campinas, SP), as well as foreign researchers from the University of British Columbia (Vancouver, Canada) and the University of Queensland (Brisbane, Australia). Research projects are aimed at investigating the structures and biological activities of secondary metabolites of marine invertebrates and microorganisms, and also from endophytic microorganisms. (Source: Lattes Curriculum)
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A holobiont is constituted by a host and its whole ecological community of associated microbes. It is a unit of evolution, and the holobiont selection is a major evolutionary force. One feature which it is still poorly addressed is the role of secondary metabolites in microbes-host relationships, as well as in chemically mediated interactions between holobionts (the microbes-host ensemble…
The chromatograph UPLC-MS / MS with accessories (including, among other items, detection system for tandem MS QTof, vacuum pump, LockSpray source with electrospray source, Lenovo digital monitor, ultra-performance chromatograph Acquity, arrangement detector diodes, MassLynx software, nitrogen generator, samples of chromatographic columns) should be used for the following purposes: a) anal…
Islands represent about 5% of the Erath’s land cover. With a very particular biodiversity, islands are considered true microcosms of the continents. The islands’ natural environment very often present a variety of endemic species, which are particularly vulnerable. Therefore, the importance of biodiversity conservation of biological species present on islands is extreme. The marine biodiv…
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Citrus is one of the most widely produced fruit globally. Brazil, particularly, is the world's largest citrus producer and exporter of frozen concentrated orange juice and citriculture represents an important percentage of Brazilian economy. However, our citriculture is facing a huge problem, the plant pathogen fungus Penicillium digitatum, which is responsible for the most common and ser…
This project aims the isolation non-ribosomal bioactive peptides named peptaibols, produced by the fungus Hypocrea sp. Peptaibols are linear peptides, generally lipophilic, with 4 to 21 amino acids, which have in their structure uncommon amino acids such as ±-aminoisobutyric acid (Aib), and isovaleric acid (Iva) and hydroxyproline imino acid (Hyp). The fungus Hypocrea sp., originating fro…
Palitantin is a secondary metabolite originally isolated from cultures of the fungus Penicillium palitans, and it is also produced by other fungal species. A fungal strain, Geomyces sp., from Antarctica, produces (-)-palitantin in a yield of about 170 mg/L, which allows the isolation of this compound to be used on a larger scale for the preparation of derivatives. As the synthesis routes …
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Among marine invertebrates, marine sponges stand out as the most metabolically diverse invertebrates. Many of the secondary metabolites isolated from marine sponges have powerful biological activities, such as halichondrins, geodiamolides, hemiasterlins, mannoalide, among many others. Therefore, marine sponges have been continuously explored as a source of bioactive secondary metabolites.…
Phomactins are diterpenes that inhibit the receptor of the platelet aggregating factor. They also reduce the repopulation of tumor cells after radiation therapy. The fungus Biatriospora sp. CBMAI 1333 produces new phomactins. Bioinformatics analysis of the genome of Biatriospora sp. CBMAI 1333 indicated terpenes-cyclase that may be involved in the biosynthesis of phomactins. The present p…
Palitantine is a secondary metabolite originally isolated from culture media of the fungus Penicillium palitans, and is also produced by other fungal species. As the palitantine synthesis routes developed to date are multi-step, with yields of up to 45% and use generally expensive and environmentally harmful reagents, a fermentative palitantine production is a good alternative to obtain g…
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This research proposal aims to advance in the elucidation of fungal biosynthetic pathways using genomics and metabolomics approaches. The first group of compounds to be investigated are the phomactins, diterpenes that inhibit the platelet aggregating factor receptor and reduce the repopulation of tumor cells after radiotherapy. The producer fungus of phomactins, Biatriospora sp. CBMAI 133…
Investigation of Roussoella sp. DLM-33 cultures revealed a new polyketide, roussoellatide,which encompasses an unprecedented carbon skeleton. The biosynthetic pathway proposed for roussoellatide was investigated by feeding experiments with labeled precursors. The hypothetical pathway requires at least two Favorskii-like rearrangements and an intermolecular [4+2]cycloaddition. Such reactio…
Genome analyses of the alpha-proteobacterium Pseudovibrio brasiliensis Ab134, a symbiont of the sponge Arenosclera brasiliensis, showed the presence of at least six biosynthetic gene clusters (BGCs) encoding the biosynthesis of secondary metabolites. Among these, a nonribosomal peptide synthetase (NRPS) BCG was shown to be involved in the swarming capability of this bacterial strain. The …
In recent years, liquid chromatography coupled to mass spectrometry has become an essential tool for metabolomics studies. Non-targeted metabolomics studies result in a large amount of data. Such mega data analyses make the evaluation and interpretation of the metabolomics outcomes highly complex. The correct annotation and subsequent unambiguous identification of metabolites from these d…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 28 / 15 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 57 / 31 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 4 | Completed scholarships abroad |
| 97 / 57 | All research grants and scholarships |
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CV Lattes
ORCID