CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor degree in Biomedical Sciences by the Federal University of Sao Paulo (2002). Graduated in Molecular Biology by the Federal University of Sao Paulo (2007), participating also in a graduate exchange program at the Max-Delbrück Institute for Molecular Medicine (Berlin, Germany). Postdoctoral fellow at Joslin Diabetes Center/Harvard Medical School (Boston, USA). Assistant Professor at the Department of Biophysics of the Federal University of Sao Paulo from 2011 to 2016. Currently holds a position of Associate Professor in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, serving as the head of Department from 2017 through 2021. He was also Research Coordinator of the Institute of Biology in the period of 2018-2020. Expertise in Molecular Biology with emphasis in Metabolism, dedicated mainly in investigating the molecular mechanisms associated with the Metabolic Syndrome and the Aging process. Affiliated Member of the Brazilian Academy of Sciences. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| En un gusano, los frenos del envejecimiento |
| Worm may help put the brakes on aging |
| En un gusano, los frenos del envejecimiento |
| News published in Agência FAPESP Newsletter about the researcher |
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| Articles published in other media outlets (0 total): |
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A number of pathways have been shown to regulate animal lifespan and organismal aging. The Antebi lab has recently discovered the nucleolus as a crucial focal point for these pathways. The nucleolus is a subnuclear organelle dedicated to rRNA production and ribogenesis, which also controls other key processes in the RNA metabolism of the cell, including small RNA processing and assembly o…
COVID-19 has recently emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechani…
The overarching aim of this proposal is to delineate the common molecular networks in adipose tissue involved in the lifespan and health promoting effects of dietary restriction and its mimetics such as dietary methionine restriction (MR) and dietary supplementation with nicotinamide riboside (NR) - a dairy constituent that maintains NAD metabolism. To achieve that, we designed a pipeline…
(Only some records are available in English at this moment)
Dr. Jeremie Boucher is a Principal Scientist at AstraZeneca, R&D CVMD iMed and Group Leader at the Wallenberg Centre for Molecular and Translational Medicine in the University of Gothenburg, where he leads bench-to-bedside projects focused on finding new molecules targeting metabolic diseases. Dr. Boucher and AstraZeneca have established a collaboration with the laboratory of Dr. Marcelo …
The incidence of metabolic diseases reached global epidemics and prescription of exercise is among the safest and most efficacious alternatives to overcome this trend. Although effective, exercise training demands discipline and may not work for all individuals on the long term. Therefore, new adjuvant strategies or mimetic interventions may help patients to control their dysfunctional me…
The overarching aim of this proposal is to delineate the common molecular networks in adipose tissue involved in the lifespan and health promoting effects of dietary restriction and its mimetics such as dietary Methionine Restriction (MR) and dietary supplementation with Nicotinamide Riboside (NR) - a dairy constituent that maintains NAD metabolism. To achieve that, we designed a pipeline…
(Only some records are available in English at this moment)
Obesity is an epidemic disease and an important risk factor for cardiometabolic disorders. Although subcutaneous fat accumulation is generally considered neutral or beneficial, visceral fat accumulation is detrimental to the pathophysiology of obesity. Men and women have different patterns of fat accumulation, which contributes to differences in the risk of developing the disease between …
COVID-19 has emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechanisms throu…
Our group has been studying oral supplementation of Nicotinamide Riboside (NR) and Pterostilbene (PT) in the context of aging (2017/01184-9). The results of this thematic study indicate that oral supplementation of NR, PT, and NRPT modulates intestinal physiology aspects. We saw lower intestinal permeability and a higher quantity of goblet cells in intestinal segments of male mice treated…
(Only some records are available in English at this moment)
Cells exchange information via secretion of molecules such as metabolites, proteins and miRNAs. Mechanisms of intercellular communication become disrupted during metabolic diseases, leading to changes in the circulating levels of these molecules. The main purpose of this project is to identify secreted molecules that exert relevant biological functions in the context of metabolic diseases…
COVID-19 has emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechanisms throu…
The circadian rhythm is a highly evolutively conserved mechanism that exists in virtually all mammalian tissues. The translational clock machinery controls the expression of many genes in a tissue-specific manner, yet most of the rhythmicity at the protein level results from post-transcriptional modifications. MicroRNAs (miRNAs) arise in this context as an important link between post-tran…
(Only some records are available in English at this moment)
Population aging represents a relevant public health issue, justifying the pursue of interventions aiming to promote health in the elderly. In the aging process, cells tend to lose the ability to properly respond to endogenous and exogenous stressors, and one relevant stress related to aging is oxidative stress. High levels of pro-oxidant molecules associated with decreased antioxidant ca…
Increased calorie intake and reduced energy expenditure are the main etiological factors in obesity. On the other hand, increased brown adipose tissue activity and recruitment of beige adipocytes are proposed to antagonize obesity-related complications. miRNAs are important regulators of metabolic processes. These small molecules are generated by a pathway that includes the rate limiting …
We are aging faster than ever before, so much that by 2050 it is expected that 22% of the world's population will represent people who are over their sixties. This is why understanding how lifespan and aging are controlled is now more important than ever. In this context, the miRNA processing pathway is of importance, since one of the enzymes that participates in this pathway - Dicer - wa…
Obesity is an epidemic disease with serious health complications. The recruitment of beige adipocytes in white adipose tissue - a phenomenon called browning - results in induced thermogenesis and increased energy expenditure and represents a promising intervention to target obesity and related diseases. Upon cold stimulation, macrophages in the adipose tissue polarize towards an M2 phenot…
Aging, obesity and the consequent increases in the prevalence of chronic diseases are serious public health issues. The adipose tissue is an important regulator of aging and obesity, and miRNAs seem to play a key role in these processes. When miRNA synthesis is blocked in the adipose tissue, mice develop lipodystrophy and exhibit premature mortality rates. Importantly, the adipose tissue …
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 10 / 10 | Ongoing scholarships in Brazil |
| 40 / 35 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 66 / 61 | All research grants and scholarships |
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