Marcelo Alves da Silva Mori
CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor degree in Biomedical Sciences by the Federal University of Sao Paulo (2002). Graduated in Molecular Biology by the Federal University of Sao Paulo (2007), participating also in an graduate exchange program at the Max-Delbrück Institute for Molecular Medicine (Berlin, Germany). Postdoctoral fellow at Joslin Diabetes Center/Harvard Medical School (Boston, USA). Assistant Professor at the Department of Biophysics of the Federal University of Sao Paulo from 2011 to 2016. Currently holds a position of Assistant Professor of Biology of Aging in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas. Expertise in Molecular Biology with emphasis in Metabolism, dedicated mainly in investigating the molecular mechanisms associated with the Metabolic Syndrome and the Aging process. Head of the Department of Biochemistry and Tissue Biology and Affiliated Member of the Brazilian Academy of Sciences. (Source: Lattes Curriculum)
- Multi-user equipment approved in grant 2017/01184-9: CFX384 touch real-time PCR detection system, AP.EMU
Abstract
The overarching aim of this proposal is to delineate the common molecular networks in adipose tissue involved in the lifespan and health promoting effects of dietary restriction and its mimetics such as dietary methionine restriction (MR) and dietary supplementation with nicotinamide riboside (NR) - a dairy constituent that maintains NAD metabolism. To achieve that, we designed a pipeli...
- CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics, AP.TEM
Abstract
The overarching aim of this proposal is to delineate the common molecular networks in adipose tissue involved in the lifespan and health promoting effects of dietary restriction and its mimetics such as dietary Methionine Restriction (MR) and dietary supplementation with Nicotinamide Riboside (NR) - a dairy constituent that maintains NAD metabolism. To achieve that, we designed a pipeli...
- Exploring the role of adipose tissue-derived circulating miRNAs in the beneficial effects of exercise training, AP.R
Abstract
The incidence of metabolic diseases reached global epidemics and prescription of exercise is among the safest and most efficacious alternatives to overcome this trend. Although effective, exercise training demands discipline and may not work for all individuals on the long term. Therefore, new adjuvant strategies or mimetic interventions may help patients to control their dysfunctional ...
- Straightening collaboration between academia and industry to explore new molecules and targets to treat metabolic diseases, AV.EXT
Abstract
Dr. Jeremie Boucher is a Principal Scientist at AstraZeneca, R&D CVMD iMed and Group Leader at the Wallenberg Centre for Molecular and Translational Medicine in the University of Gothenburg, where he leads bench-to-bedside projects focused on finding new molecules targeting metabolic diseases. Dr. Boucher and AstraZeneca have established a collaboration with the laboratory of Dr. Marcel...
- Dicer, miRNAs and the control of mitochondrial function in the context of aging and caloric restriction, AP.R
Abstract
Aging is one of the main risk factors for chronic diseases and has been increasing in prevalence worldwide in the past few decades. Advances in the understanding of the mechanisms involved in the aging process and how interventions can delay or prevent its deleterious consequences are thus becoming urgent. Health span can be increased in different species, including in primates, by meta...
- Characterization in mice of novel genes involved in the evolutionarily conserved mechanisms of dietary restriction and its mimetics, BP.PD
Abstract
Dietary restriction extends lifespan across species from yeast to primates. It is well established that dietary restricted mice live longer than ad libitum fed mice and are protected from metabolic diseases like diabetes and obesity, as well as cancer, cardiovascular disease and other age-related complications. In mammals, part of the beneficial effect of dietary restriction is thought ...
- Characterization in C. elegans of novel genes involved in aging and the evolutionarily conserved mechanisms of dietary restriction mimetics, BP.DD
Abstract
Dietary restriction extends lifespan across species from yeast to primates. The study of the nematode C. elegans - where multiple protocols of dietary restriction has been shown to prolong lifespan in overlapping yet not necessarily identical manners has led to the identification of multiple evolutionarily conserved pathways associated with aging and the mechanisms of dietary restrictio...
- Uncovering new regulators of DAF-16/FOXO expression, BP.MS
Abstract
Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a conserved role in aging. In C. elegans, key components of this pathway are the insulin/IGF-1 receptor ortholog DAF-2 and the FoxO transcription factor ortholog DAF-16. Mutations in the daf-2 gene make worms live twice as long, and this phenomenon is entirely dependent on DAF-16 activation. Similarly, other ...
(Only some records are available in English at this moment)
- Use of science journalism to communicate the research developed by the Department of Biochemistry and tissue biology, in the Biology Institute of the University of Campinas, BP.JC
Abstract
Brazilians are very interested in science. Still, the country has few science communication initiatives that create quality scientific content that is readily available, and easily understood. To address this problem, the country needs specialized science journalists, who are capable of filling the gap between scientists and society. The Department of Biochemistry and Tissue Biology, i...
- Varredura e caracterização de moléculas circulantes que afetam o gasto energético, BP.DR
Abstract
The prevalence of obesity has been growing worldwide alongside its comorbidities. Current anti-obesity therapies appear to be poorly efficient, especially on the long-term, and are associated with significant side effects. There are two ways to lose weight: by decreasing energy intake or increasing energy expenditure. One way to increase energy expenditure in mammals is through the stim...
- Evaluation of the diurnal expression pattern of Dicer enzyme and its influence on the expression of clock genes in adipocytes, BP.IC
Abstract
Obesity is one of the greatest problems of public health in the world today, especially because of its epidemic and growing character. Overweight and obesity are risk factors for many diseases, such as type 2 diabetes, cardiovascular diseases and cancer, and the increase in adipose tissue is closely related to the incidence of these pathologies. Adipose tissue, combined with the biologi...
(Only some records are available in English at this moment)
- Determining the role of conserved, fat-enriched circulating miRNAs in aging and in triacylglycerol accumulation of Drosophila melanogaster, BE.EP.DR
Abstract
Aging, obesity and the consequent increases in the prevalence of chronic diseases are serious public health issues. The adipose tissue is an important regulator of aging and obesity, and miRNAs seem to play a key role in these processes. When miRNA synthesis is blocked in the adipose tissue, mice develop lipodystrophy and exhibit premature mortality rates. Importantly, the adipose tissu...
- Identification of soma-germline interactions that may influence lifespan in Caenorhabditis elegans, BE.EP.MS
Abstract
C. elegans is a widely used model for aging studies due to its short lifespan and conserved genes that can be easily silenced by feeding worms with bacteria that express target-specific double stranded RNA (dsRNA). Worms carrying a loss-of-function mutation in the glp-1 gene do not develop the germline and therefore are long-lived - a phenomenon directly linked to increased nuclear loca...
- The involvement of the microRNA biogenesis pathway in the process of adipocyte differentiation, BE.EP.MS
Abstract
Obesity is reaching epidemic proportions and leading to a worldwide increase in the prevalence of multiple comorbidities, including diabetes and cancer. Obesity is characterized by an increase in adipose tissue mass due to a positive energy balance. The adipose tissue is constituted of a functional unit called the adipocyte, which may play distinct roles depending on its developmental o...
*Updated March 16, 2019
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 9 |
| Citations | 310 |
| Cit./Article | 34.4 |
| Data from Web of Science | |
MORI, MARCELO A.; THOMOU, THOMAS; BOUCHER, JEREMIE; LEE, KEVIN Y.; LALLUKKA, SUSANNA; KIM, JASON K.; TORRIANI, MARTIN; YKI-JAERVINEN, HANNELE; GRINSPOON, STEVEN K.; CYPESS, AARON M.; et al. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. Journal of Clinical Investigation, v. 124, n. 8, p. 3339-3351, AUG 2014. Web of Science Citations: 56.
THOMOU, THOMAS; MORI, MARCELO A.; DREYFUSS, JONATHAN M.; KONISHI, MASAHIRO; SAKAGUCHI, MASAJI; WOLFRUM, CHRISTIAN; RAO, TATA NAGESWARA; WINNAY, JONATHON N.; GARCIA-MARTIN, RUBEN; GRINSPOON, STEVEN K.; et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature, v. 542, n. 7642, p. 450+, FEB 23 2017. Web of Science Citations: 187. (15/01316-7)
OLIVERIO, MATTEO; SCHMIDT, ELENA; MAUER, JAN; BAITZEL, CATHERINA; HANSMEIER, NILS; KHANI, SAJJAD; KONIECZKA, SANDRA; PRADAS-JUNI, MARTA; BRODESSER, SUSANNE; VAN, TRIEU-MY; et al. Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. Nature Cell Biology, v. 18, n. 3, p. 328+, MAR 2016. Web of Science Citations: 27.
BRANDAO, BRUNA B.; GUERRA, BEATRIZ A.; MORI, MARCELO A.. Shortcuts to a functional adipose tissue: The role of small non-coding RNAs. REDOX BIOLOGY, v. 12, p. 82-102, AUG 2017. Web of Science Citations: 16. (15/03292-8, 15/01316-7)
LUDWIG, RAISSA G.; ROCHA, ANDREA L.; MORI, MARCELO A.. Circulating molecules that control brown/beige adipocyte differentiation and thermogenic capacity. Cell Biology International, v. 42, n. 6, SI, p. 701-710, JUN 2018. Web of Science Citations: 1. (15/20822-0, 17/01184-9, 15/01316-7, 16/12294-7, 17/07975-8)
REIS, FELIPE C. G.; BRANQUINHO, JESSICA L. O.; BRANDAO, BRUNA B.; GUERRA, BEATRIZ A.; SILVA, ISMAEL D.; FRONTINI, ANDREA; THOMOU, THOMAS; SARTINI, LORIS; CINTI, SAVERIO; KAHN, C. RONALD; et al. Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice. AGING-US, v. 8, n. 6, p. 1201-1222, JUN 2016. Web of Science Citations: 15. (11/24109-6, 15/01316-7)
FERRAZ, RAFAEL C.; CAMARA, HENRIQUE; DE-SOUZA, EVANDRO A.; PINTO, SILAS; PINCA, ANA PAULA F.; SILVA, RICHARD C.; SATO, VITOR N.; CASTILHO, BEATRIZ A.; MORI, MARCELO A.. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. BMC Biology, v. 14, OCT 7 2016. Web of Science Citations: 3. (09/52047-5, 14/10814-8, 15/04264-8, 14/25068-0, 15/01316-7, 14/25270-3, 12/24490-4, 14/17145-4, 12/04064-0)
ABE‚ K.C.; DA SILVA MORI‚ M.A.; PESQUERO‚ J.B.. Leptin deficiency leads to the regulation of kinin receptors expression in mice. Regulatory Peptides, v. 138, n. 2-3, p. 56-58, 2007.
OTTON, ROSEMARI; BOLIN, ANAYSA PAOLA; FERREIRA, LETICIA TORRES; MARINOVIC, MARCELO PARADISO; SILVA ROCHA, ANDREA LIVIA; MORI, MARCELO ALVES. Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 57, p. 170-179, JUL 2018. Web of Science Citations: 5. (13/22293-0, 15/01316-7)
PINTO, SILAS; SATO, VITOR N.; DE-SOUZA, EVANDRO A.; FERRAZ, RAFAEL C.; CAMARA, HENRIQUE; PINCA, ANA PAULA F.; MAZZOTTI, DIEGO R.; LOVCI, MICHAEL T.; TONON, GUILHERME; LOPES-RAMOS, CAMILA M.; et al. Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. REDOX BIOLOGY, v. 18, p. 84-92, SEP 2018. Web of Science Citations: 0. (15/04264-8, 17/01184-9, 14/25068-0, 15/01316-7, 14/25270-3, 12/24490-4, 14/10814-8, 12/04064-0, 17/04377-2)