Marcelo Alves da Silva Mori
CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor degree in Biomedical Sciences by the Federal University of Sao Paulo (2002). Graduated in Molecular Biology by the Federal University of Sao Paulo (2007), participating also in a graduate exchange program at the Max-Delbrück Institute for Molecular Medicine (Berlin, Germany). Postdoctoral fellow at Joslin Diabetes Center/Harvard Medical School (Boston, USA). Assistant Professor at the Department of Biophysics of the Federal University of Sao Paulo from 2011 to 2016. Currently holds a position of Assistant Professor of Biology of Aging in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas. Expertise in Molecular Biology with emphasis in Metabolism, dedicated mainly in investigating the molecular mechanisms associated with the Metabolic Syndrome and the Aging process. Head of the Department of Biochemistry and Tissue Biology and Affiliated Member of the Brazilian Academy of Sciences. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Study identifies potential target for treatment of COVID-19 |
| FAPESP selects 30 projects in call for research proposals to combat novel coronavirus |
| Researchers join forces to combat coronavirus |
- Determining molecular candidates that contribute to the higher risk of COVID-19 in aged individuals, AP.R
Abstract
COVID-19 has recently emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mecha...
- Multi-user equipment approved in grant 2017/01184-9: CFX384 touch real-time PCR detection system, AP.EMU
Abstract
The overarching aim of this proposal is to delineate the common molecular networks in adipose tissue involved in the lifespan and health promoting effects of dietary restriction and its mimetics such as dietary methionine restriction (MR) and dietary supplementation with nicotinamide riboside (NR) - a dairy constituent that maintains NAD metabolism. To achieve that, we designed a pipeli...
- CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics, AP.TEM
Abstract
The overarching aim of this proposal is to delineate the common molecular networks in adipose tissue involved in the lifespan and health promoting effects of dietary restriction and its mimetics such as dietary Methionine Restriction (MR) and dietary supplementation with Nicotinamide Riboside (NR) - a dairy constituent that maintains NAD metabolism. To achieve that, we designed a pipeli...
(Only some records are available in English at this moment)
- Straightening collaboration between academia and industry to explore new molecules and targets to treat metabolic diseases, AV.EXT
Abstract
Dr. Jeremie Boucher is a Principal Scientist at AstraZeneca, R&D CVMD iMed and Group Leader at the Wallenberg Centre for Molecular and Translational Medicine in the University of Gothenburg, where he leads bench-to-bedside projects focused on finding new molecules targeting metabolic diseases. Dr. Boucher and AstraZeneca have established a collaboration with the laboratory of Dr. Marcel...
- Exploring the role of adipose tissue-derived circulating miRNAs in the beneficial effects of exercise training, AP.R
Abstract
The incidence of metabolic diseases reached global epidemics and prescription of exercise is among the safest and most efficacious alternatives to overcome this trend. Although effective, exercise training demands discipline and may not work for all individuals on the long term. Therefore, new adjuvant strategies or mimetic interventions may help patients to control their dysfunctional ...
- Dicer, miRNAs and the control of mitochondrial function in the context of aging and caloric restriction, AP.R
Abstract
Aging is one of the main risk factors for chronic diseases and has been increasing in prevalence worldwide in the past few decades. Advances in the understanding of the mechanisms involved in the aging process and how interventions can delay or prevent its deleterious consequences are thus becoming urgent. Health span can be increased in different species, including in primates, by meta...
- Investigation of new tissue-specific mechanisms of aging control by caloric restriction in C. elegans, BP.DR
Abstract
There is a worldwide trend towards aging of the world's population, what gives rise to social, economic and public health issues. Caloric Restriction (CR) is an intervention that slows down the aging process in different species resulting in a reduction in the risk of age-related diseases. Aging and CR affect the cells of the organism in an indiscriminate manner. However, some cells see...
- Assessment of exosome circadian rhythmicity in mice, BP.MS
Abstract
The circadian rhythm is a highly evolutively conserved mechanism that exists in virtually all mammalian tissues. The translational clock machinery controls the expression of many genes in a tissue-specific manner, yet most of the rhythmicity at the protein level results from post-transcriptional modifications. MicroRNAs (miRNAs) arise in this context as an important link between post-tr...
- Study of the role of ALG-1 and its regulatory mechanisms in healthspan of Caenorhabditis elegans, BP.DD
Abstract
Population aging represents an important social problem in the 21st century and mobilizes the attention of public agencies for the elaboration of interventions aiming to preserve vitality and increase healthspan. miRNAs and the proteins involved in their biogenesis and function, such as the argonaute ALG-1, are important elements controlling healthspan. In a previous study, our group ob...
(Only some records are available in English at this moment)
- Role of Dicer in beige adipocyte differentiation and the influence of macrophages in this process, BP.IC
Abstract
Obesity affects a large part of the world population, being associated with several health complications, such as cardiovascular diseases and diabetes. Adipose tissue can either store energy, in white adipocytes, or dissipate it as heat in brown or beige adipocytes. This thermogenic process can be stimulated by cold through the browning mechanism, which is mediated mainly by uncoupling ...
- Use of science journalism to communicate the research developed by the Department of Biochemistry and tissue biology, in the Biology Institute of the University of Campinas, BP.JC
Abstract
Brazilians are very interested in science. Still, the country has few science communication initiatives that create quality scientific content that is readily available, and easily understood. To address this problem, the country needs specialized science journalists, who are capable of filling the gap between scientists and society. The Department of Biochemistry and Tissue Biology, i...
- Uncovering new regulators of DAF-16/FOXO expression, BP.MS
Abstract
Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a conserved role in aging. In C. elegans, key components of this pathway are the insulin/IGF-1 receptor ortholog DAF-2 and the FoxO transcription factor ortholog DAF-16. Mutations in the daf-2 gene make worms live twice as long, and this phenomenon is entirely dependent on DAF-16 activation. Similarly, other ...
(Only some records are available in English at this moment)
- Investigation of mechanisms of miRNA biogenesis activation by the beta-adrenergic pathway, BE.EP.DR
Abstract
Increased calorie intake and reduced energy expenditure are the main etiological factors in obesity. On the other hand, increased brown adipose tissue activity and recruitment of beige adipocytes are proposed to antagonize obesity-related complications. miRNAs are important regulators of metabolic processes. These small molecules are generated by a pathway that includes the rate limitin...
- Determining mechanisms of miRNA-mediated Macrophage-Adipocyte crosstalk, BE.EP.DR
Abstract
Obesity is an epidemic disease with serious health complications. The recruitment of beige adipocytes in white adipose tissue - a phenomenon called browning - results in induced thermogenesis and increased energy expenditure and represents a promising intervention to target obesity and related diseases. Upon cold stimulation, macrophages in the adipose tissue polarize towards an M2 phen...
- Screening and characterization of Dicer regulators in c. elegans, BE.EP.MS
Abstract
We are aging faster than ever before, so much that by 2050 it is expected that 22% of the world's population will represent people who are over their sixties. This is why understanding how lifespan and aging are controlled is now more important than ever. In this context, the miRNA processing pathway is of importance, since one of the enzymes that participates in this pathway - Dicer - ...
- Determining the role of conserved, fat-enriched circulating miRNAs in aging and in triacylglycerol accumulation of Drosophila melanogaster, BE.EP.DR
Abstract
Aging, obesity and the consequent increases in the prevalence of chronic diseases are serious public health issues. The adipose tissue is an important regulator of aging and obesity, and miRNAs seem to play a key role in these processes. When miRNA synthesis is blocked in the adipose tissue, mice develop lipodystrophy and exhibit premature mortality rates. Importantly, the adipose tissu...
- Identification of soma-germline interactions that may influence lifespan in Caenorhabditis elegans, BE.EP.MS
Abstract
C. elegans is a widely used model for aging studies due to its short lifespan and conserved genes that can be easily silenced by feeding worms with bacteria that express target-specific double stranded RNA (dsRNA). Worms carrying a loss-of-function mutation in the glp-1 gene do not develop the germline and therefore are long-lived - a phenomenon directly linked to increased nuclear loca...
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 12 / 12 | Ongoing scholarships in Brazil |
| 30 / 25 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 56 / 50 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 493 |
| Cit./Article | 27.4 |
| Data from Web of Science | |
ABE‚ K.C.; DA SILVA MORI‚ M.A.; PESQUERO‚ J.B.. Leptin deficiency leads to the regulation of kinin receptors expression in mice. Regulatory Peptides, v. 138, n. 2-3, p. 56-58, 2007.
PINTO, SILAS; SATO, VITOR N.; DE-SOUZA, EVANDRO A.; FERRAZ, RAFAEL C.; CAMARA, HENRIQUE; PINCA, ANA PAULA F.; MAZZOTTI, DIEGO R.; LOVCI, MICHAEL T.; TONON, GUILHERME; LOPES-RAMOS, CAMILA M.; et al. Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. REDOX BIOLOGY, v. 18, p. 84-92, SEP 2018. Web of Science Citations: 6. (15/04264-8, 17/01184-9, 14/25068-0, 15/01316-7, 14/25270-3, 12/24490-4, 14/10814-8, 12/04064-0, 17/04377-2)
FERRAZ, RAFAEL C.; CAMARA, HENRIQUE; DE-SOUZA, EVANDRO A.; PINTO, SILAS; PINCA, ANA PAULA F.; SILVA, RICHARD C.; SATO, VITOR N.; CASTILHO, BEATRIZ A.; MORI, MARCELO A.. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. BMC Biology, v. 14, OCT 7 2016. Web of Science Citations: 6. (09/52047-5, 14/10814-8, 15/04264-8, 14/25068-0, 15/01316-7, 14/25270-3, 12/24490-4, 14/17145-4, 12/04064-0)
THOMOU, THOMAS; MORI, MARCELO A.; DREYFUSS, JONATHAN M.; KONISHI, MASAHIRO; SAKAGUCHI, MASAJI; WOLFRUM, CHRISTIAN; RAO, TATA NAGESWARA; WINNAY, JONATHON N.; GARCIA-MARTIN, RUBEN; GRINSPOON, STEVEN K.; et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature, v. 542, n. 7642, p. 450+, FEB 23 2017. Web of Science Citations: 323. (15/01316-7)
MORI, MARCELO A.; LUDWIG, RAISSA G.; GARCIA-MARTIN, RUBEN; BRANDAO, BRUNA B.; KAHN, C. RONALD. Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease. Cell Metabolism, v. 30, n. 4, p. 656-673, OCT 1 2019. Web of Science Citations: 3. (17/07975-8, 17/23920-9, 17/01184-9)
LIMA, TANES I.; GUIMARAES, DIMITRIUS SANTIAGO P. S. F.; OLIVEIRA, ANDRE G.; ARAUJO, HYGOR; SPONTON, CARLOS H. G.; SOUZA-PINTO, NADJA C.; SAITO, ANGELA; FIGUEIRA, ANA CAROLINA M.; PALAMETA, SOLEDAD; BAJGELMAN, MARCIO CHAIM; et al. Opposing action of NCoR1 and PGC-1 alpha in mitochondrial redox homeostasis. Free Radical Biology and Medicine, v. 143, p. 203-208, NOV 1 2019. Web of Science Citations: 0. (16/23008-5, 17/21628-9, 17/04377-2)
BRAGA, DEISI L.; MOUSOVICH-NETO, FELIPPE; TONON-DA-SILVA, GUILHERME; SALGUEIRO, WILLIAN G.; MORI, MARCELO A.. Epigenetic changes during ageing and their underlying mechanisms. BIOGERONTOLOGY, APR 2020. Web of Science Citations: 0. (17/22057-5, 17/08829-5, 18/11672-3, 17/01184-9, 19/14391-8, 18/11792-9)
REIS, FELIPE C. G.; BRANQUINHO, JESSICA L. O.; BRANDAO, BRUNA B.; GUERRA, BEATRIZ A.; SILVA, ISMAEL D.; FRONTINI, ANDREA; THOMOU, THOMAS; SARTINI, LORIS; CINTI, SAVERIO; KAHN, C. RONALD; et al. Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice. AGING-US, v. 8, n. 6, p. 1201-1222, JUN 2016. Web of Science Citations: 16. (11/24109-6, 15/01316-7)
BRANDAO, BRUNA B.; GUERRA, BEATRIZ A.; MORI, MARCELO A.. Shortcuts to a functional adipose tissue: The role of small non-coding RNAs. REDOX BIOLOGY, v. 12, p. 82-102, AUG 2017. Web of Science Citations: 24. (15/03292-8, 15/01316-7)
LUDWIG, RAISSA G.; ROCHA, ANDREA L.; MORI, MARCELO A.. Circulating molecules that control brown/beige adipocyte differentiation and thermogenic capacity. Cell Biology International, v. 42, n. 6, SI, p. 701-710, JUN 2018. Web of Science Citations: 1. (15/01316-7, 15/20822-0, 17/07975-8, 16/12294-7, 17/01184-9)
OLIVERIO, MATTEO; SCHMIDT, ELENA; MAUER, JAN; BAITZEL, CATHERINA; HANSMEIER, NILS; KHANI, SAJJAD; KONIECZKA, SANDRA; PRADAS-JUNI, MARTA; BRODESSER, SUSANNE; VAN, TRIEU-MY; et al. Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. Nature Cell Biology, v. 18, n. 3, p. 328+, MAR 2016. Web of Science Citations: 34.
SALES, VICENCIA M.; GONCALVES-ZILLO, THAIS; CASTOLDI, ANGELA; BURGOS, MARINA; BRANQUINHO, JESSICA; BATISTA, CAROLINA; OLIVEIRA, VALERIA; SILVA, ELTON; CASTRO, CHARLLES H. M.; CAMARA, NIELS; et al. Kinin B-1 Receptor Acts in Adipose Tissue to Control Fat Distribution in a Cell-Nonautonomous Manner. Diabetes, v. 68, n. 8, p. 1614-1623, AUG 2019. Web of Science Citations: 1. (17/07975-8, 14/27198-8, 17/01184-9)
OTTON, ROSEMARI; BOLIN, ANAYSA PAOLA; FERREIRA, LETICIA TORRES; MARINOVIC, MARCELO PARADISO; SILVA ROCHA, ANDREA LIVIA; MORI, MARCELO ALVES. Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 57, p. 170-179, JUL 2018. Web of Science Citations: 11. (13/22293-0, 15/01316-7)
FERRUCCI, DANILO; SILVA, SILAS PINTO; ROCHA, ANDR; NASCIMENTO, LUCAS; VIEIRA, ANDRE SCHWAMBACH; TABOGA, SEBASTIAO ROBERTO; MORI, MARCELO; LENZ-CESAR, CARLOS; CARVALHO, HERNANDES F.. Dietary fatty acid quality affects systemic parameters and promotes prostatitis and pre-neoplastic lesions. SCIENTIFIC REPORTS, v. 9, DEC 17 2019. Web of Science Citations: 0. (14/50938-8, 09/16150-6, 17/04377-2)
PEREIRA, CATIA M.; FILEV, RENATO; DUBIELA, FRANCISCO P.; BRANDAO, BRUNA B.; QUEIROZ, CLAUDIO M.; LUDWIG, RAISSA G.; HIPOLIDE, DEBORA; LONGO, BEATRIZ M.; MELLO, LUIZ E.; MORI, MARCELO A.; et al. The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control. PLoS One, v. 14, n. 6, JUN 5 2019. Web of Science Citations: 0. (09/52047-5, 12/04079-8)
DE-SOUZA, EVANDRO A.; PIMENTEL, FELIPE S. A.; DE-QUEIROZ, ANA LUIZA F. V.; CAMARA, HENRIQUE; FELIX-FORMIGA, MIKAELLA L.; MACHADO, CAIO M.; PINTO, SILAS; GALINA, ANTONIO; MORI, MARCELO A.; MONTERO-LOMELI, MONICA; et al. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium?galactose?mediated activation of the unfolded protein response. Journal of Biological Chemistry, v. 295, n. 12, p. 3773-3782, MAR 20 2020. Web of Science Citations: 0. (17/04377-2, 17/01339-2, 17/01184-9)
GUERRA, BEATRIZ A.; BRANDAO, BRUNA B.; PINTO, SILAS S.; SALGUEIRO, WILLIAN G.; DE-SOUZA, EVANDRO A.; REIS, FELIPE C. G.; BATISTA, THIAGO M.; CAVALCANTE-SILVA, VANESSA; D'ALMEIDA, VANIA; CASTILHO, BEATRIZ A.; et al. Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects. MOLECULAR METABOLISM, v. 29, p. 124-135, NOV 2019. Web of Science Citations: 0. (15/03292-8, 17/22057-5, 16/02207-0, 17/01184-9, 15/01316-7, 15/19530-5, 12/07259-7, 17/07975-8)
DE-SOUZA, EVANDRO A.; CAMARA, HENRIQUE; SALGUEIRO, WILLIAN G.; MORO, RAISSA P.; KNITTEL, THIAGO L.; TONON, GUILHERME; PINTO, SILAS; PINCA, ANA PAULA F.; ANTEBI, ADAM; PASQUINELLI, AMY E.; et al. RNA interference may result in unexpected phenotypes in Caenorhabditis elegans. Nucleic Acids Research, v. 47, n. 8, p. 3957-3969, MAY 7 2019. Web of Science Citations: 3. (17/22057-5, 14/10814-8, 17/08829-5, 17/01184-9, 15/01316-7, 14/25068-0, 17/01339-2, 17/03423-0, 12/00195-3, 16/02207-0, 16/15958-3, 17/04377-2)
MORI, MARCELO A.; THOMOU, THOMAS; BOUCHER, JEREMIE; LEE, KEVIN Y.; LALLUKKA, SUSANNA; KIM, JASON K.; TORRIANI, MARTIN; YKI-JAERVINEN, HANNELE; GRINSPOON, STEVEN K.; CYPESS, AARON M.; et al. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. Journal of Clinical Investigation, v. 124, n. 8, p. 3339-3351, AUG 2014. Web of Science Citations: 65.
(References retrieved automatically from State of São Paulo Research Institutions)
LUDWIG, Raissa Guimarães. Caracterização metabólica de adipócitos em resposta ao soro de roedores submetidos à restrição dietética. Dissertação (Mestrado) - Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). (15/20822-0)
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