Abstract
The heart is subjected to different hormonal stimulus, which can directly or indirectly influence its trophic status. The angiotensin II (Ang II), characterized as the main effector of Renin-Angiotensin System (RAS), is a potent vasoactive peptide and exerts numerous biological effects through its receptors (AT1 and AT2). In cardiac tissue, Ang II promotes cardiomyocyte hypertrophy and hy…