Helena Bacha Lopes

• Abstract

  The extracellular matrix (ECM) is a three-dimensional structure secreted by cells in the extracellular space, composed of proteins and polysaccharides in different combinations, forming a specific matrix for each type of tissue. Among the functions performed by the ECM are the regulation of gene expression, organization of the cytoskeleton, and actions in morphology, proliferation, viabil…

  Effect of titanium with nanotopography on formation and remodeling of extracellular matrix produced by osteoblasts, BP.IC

• Abstract

  Previous studies of our research group have shown that the use of cell therapy has great potential to repair bone tissue; however, without yet inducing complete tissue regeneration. Based on this, we are developing a FAPESP-funded project (Thematic Project, Process No. 2017 / 12622-7) to establish a mesenchymal stem cell line (MSC) overexpressing bone morphogenetic protein 9 (BMP-9) using…

  Effect of BMP-9 overexpression on osteoblast differentiation of mesenchymal stem cell, BP.IC

• Abstract

  Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…

  Evaluation of the osteogenic and bone tissue regeneration potentials of BM-MSCs and AT-MSCs associated with VEGF-A and BMP-9, BP.PD

(Only some records are available in English at this moment)

• Abstract

  Interactions between cells and titanium (Ti) are crucial for dental implant osseointegration. The integrins mediate adhesion of cells to extracellular matrix proteins and some members are involved in the process of osteoblast differentiation. Results of the project entitled "Role of Integrins on Osteoblast Differentiation of Mesenchymal Stem Cells Induced by Titanium Surfaces with Micro a…

  Use of CRISPR-Cas9 to Investigate the Role of Integrins on Osteoblast Differentiation of Mesenchymal Stem Cells Induced by Titanium Surfaces, BE.EP.DR

• Abstract

  Recent studies have shown that osteogenesis can be regulated by post-transcriptional mechanisms such as temporary expression of microRNAs (miRs). The interaction of miRs with its messenger RNA (mRNA) target alters the stability of the mRNA and inhibits the translational process and thereafter the protein expression. MicroRNAs are involved in a plethora of biological processes, including e…

  Large-scale analysis of the microRNAs expression in RNA samples obtained from newly formed bone tissue in contact with PTFE and PVDF membranes, BE.EP.MS