Postdoctoral researcher at the Special Laboratory of Cell Cycle (LECC), Butantan Institute, São Paulo, Brazil (since 2017). PhD and Master's Degree in Science (Biochemistry), with a focus in cancer molecular and cellular biology, by the Institute of Chemistry, University of São Paulo (USP), São Paulo, Brazil (2011-2017), comprising a one-year stage as a visitor PhD student, at the Istitute of Molecular Biology and Pathology (IMBP), National Research Council, Department of Biology and Biotecnology - Charles Darwin (CNR), Rome, Italy (2015-2016). Bachelor's Degree in Pharmacy and Biochemistry, by Oswaldo Cruz University (FOC), São Paulo, Brazil (2005-2010). Currently enrolled at the School of Medicine of the University of São Paulo (FMUSP) São Paulo, Brazil. (Source: Lattes Curriculum)
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We previously reported that Kras-driven Y1 tumor cells exhibit an unlikely association of high basal levels of K-Ras-GTP with cell cycle arrest by Fibroblast Growth Factor 2 (FGF2). Furthermore, in Y1 cells, experimental ectopic expression of an inducible dominant negative mutant, Ras-N17, reduced K-Ras-GTP basal levels and rescued FGF2 mitogenic activity (Costa et al. 2008; Salotti et al…
Lung cancer is the leading cause of cancer mortality worldwide. The most frequent genetic changes found in lung cancer are activating point mutations in the K-Ras gene. Although K-Ras mutations have been causally linked to the oncogenic process, different approaches to target K-Ras for therapy have been unsuccessful. Therefore, in order to select better targets for lung cancer therapy, th…
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