CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Farmacy (1998), Master and ph.D in Science (Human Physiology) by the Institute of Biomedical Sciences, University of São Paulo (2005) and completed her postdoctoral studies in Biochemistry by the Boston University, School of Medicine (2007). She is Assistant Professor in the Department of Biological Sciences at the Federal University of São Paulo. She leads the young investigator research project entitled: Effects of fatty acids on the differentiation and function of white adipose tissue. She has published more than 30 papers in this área of investigation. Has experience in Adipose Tissue, focusing on Energy Metabolism, acting on the following subjects: fatty acids, insulin resistance and adipokines. (Source: Lattes Curriculum)
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The adipose tissue (TA) shows high plasticity when answering different individual metabolic demands. The major cell responsible for these answers is the mature adipocyte, but mesenchymal stem cells (AdSCs) residing in the adipose tissue stromal vascular fraction provide a source of differentiation for new adipocytes. During adipogenesis, epigenetic changes on histone 3 lysine 27 (H3K27) a…
Our research group has been investigating the role of fatty acids (FAs) as bioactive substance in white adipose tissue (WAT), particularly the palmitoleic acid (of the omega-7 class) and fish oil (FO) rich in É-3 polyunsaturated FAs. The present study proposes a therapeutic approach with these FAs in mice submitted to obesity induced by a high fat diet in order to understand a possible ro…
The growing interest in studying the function of adipose tissue is due not only to concerns about obesity and its metabolic consequences, but also by the recognition that adipocytes integrate a wide range of homeostatic processes. Although there are many studies showing the effects of fatty acids (FA) on systemic metabolism and the consensus that the high consumption of saturated FA is as…
White adipose tissue (WAT) has a high plasticity, responding to different metabolic demands, diets and drugs. The main cell responsible for these responses is the mature adipocyte, but mesenchymal stem cells contained in the vascular stromal fraction of WAT (AdSCs) allow its expansion through differentiation into new adipocytes. The commitment of AdSCs to the adipogenesis process depends …
The present study proposes an analysis of lipid profile and functional genomics with emphasis on signaling pathways in cells from White Adipose Tissue (WAT), adipocytes and WAT-derived mesenchymal stem cells (AdSCs), using a therapeutic approach with fish oil [FO, rich in É-3 polyunsaturated Fatty Acids (FA)] in High Fat Diet (HFD)-Induced Obese (DIO) mice. The objective is to understand …
A high-fat diet leads to obesity, a condition that generates important changes in white adipose tissue (WAT). Mesenchymal stem cells derived from adipose tissue (adipose derived Stromal Cells - AdSC) are responsible for generating new adipocytes, expanding adipose tissue. Changes in the expression of transcription factors and epigenetic marks in the nucleus of AdSCs may have effects on th…
Overweight and obesity are associated with metabolic disorders such as insulin resistance, dyslipidemia, hypertension, among others, that led to metabolic syndrome. The prevalence of sedentary lifestyle and the transition to a high-calorie food, rich in saturated fat acids and simple sugars, has turned obesity into a global health problem. In fact, the increase in the prevalence of overwe…
Obesity is a chronic disease defined as the excessive accumulation of body lipids in adipose tissue and ectopically in other tissues such as the liver, pancreas and skeletal muscle, and it can be associated with other comorbidities such as type 2 diabetes mellitus, myocardial infarction, hypertension, and some cancers. The incidence of obesity worldwide is increasing every year, and this …
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Obesity is becoming a global epidemic and is linked to other diseases including hypertension, cardiovascular disease, diabetes and even some types of cancers. The incidence of obesity worldwide is increasing every year, and this is an indication that current and oncoming therapeutic strategies are not yet fully effective. Recent data suggest that adipocyte mitochondria might play an impor…
| 1 / 1 | Ongoing research grants |
| 11 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 9 / 6 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 25 / 13 | All research grants and scholarships |
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