graduate at Licenciatura Plena em Educação Física from Universidade de São Paulo (1991) and ph.d. at Physiology from Universidade de São Paulo (1998). Has experience in Physiology, focusing on Cardiovascular Physiology, acting on the following subjects: angiogenesis, treinamento fisico, hipertensão, microcirculation and vegf. (Source: Lattes Curriculum)
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Heart failure (HF) is a complex syndrome that affects 23 million people worldwide. The heart of HF patients presents cardiac remodeling, cardiac dysfunction and some of the implications involved in cardiac remodeling are determined mainly by inflammation. Thus, we hypothesized that treatment with dexamethasone (DEX) may identify cytokines which could be used as therapeutic target for card…
Hypertension is the main risk factor for cardiovascular diseases and has been considered an important health problem. We have previously shown that chronic dexamethasone (DEX) treatment determined hypertension; however, the responsible mechanisms are not completely elucidated. Since hypertensive individuals may have use DEX, is reasonable to think that DEX treatment would increase even mo…
Many factors appear to affect fluoride metabolism, however, there is limited and often contradictory evidence from the literature on the effect of exercise on fluoride metabolism. The primary aim of Dra Liane Azevedo visit is to collect data for a feasibility trial aiming to inform the design of a full trial targeting the effect of physical activity on fluoride metabolism. Dra Azevedo was…
Dexamethasone (DEX) is widely used in clinics due to its potent effect as anti-allergic and anti-inflammatory drug, however its chronic use may cause several metabolic and haemodynamic alterations. It has been shown that DEX treatment provokes hypertension and muscle atrophy, however the mechanisms responsible for these effects are not totally understood. We recently have shown that renin…
(Only some records are available in English at this moment)
The use of dexamethasone (DEX), widely used in the clinic, is related to the loss of species diversity in the intestinal microbiota, which may determine a modulation in the host's immune response. On the other hand, the use of probiotics, as well as physical training, has been shown to influence the microbiota, however, its effects are still inconclusive. Therefore, the aim of the present…
It has been shown that intestinal microbiota has a great relationship with the immunity of an individual, achieving relevance in many cardiovascular diseases. The intestinal barrier function is essential to the control of pathogens entry into the vascular system. One of these pathogens is the lipopolysaccharide, a pro-inflammatory endotoxin. In the literature, a systemic inflammation stat…
Among all consequences of hypertension, cardiovascular diseases are the major contributing to mortality. Factor such cardiac hypertrophy, fibrosis and myocardium capillary density loss are involved. Spontaneously hypertensive rats (SHR) have cardiac remodeling due to hypertension and because of that, several pharmacological and non-pharmacological treatments are used. Among inhibitors of …
Heart failure (HF) is one of the most deadly cardiovascular diseases in Brazil. Cardiac hypertrophy, increased fibrosis and capillary density reduction are implicated in its development. Spontaneously hypertensive rats (SHR), throughout their life, develop cardiac hypertrophy due to arterial hypertension (HA) evolution. However, little is known about dexamethasone-effects (DEX) in these a…
(Only some records are available in English at this moment)
Dexamethasone (DEX) is used as anti-inflammatory and immunosuppressant drug. DEX treatment side-effects are several including muscle weakness, hypertension and microvascular rarefaction, which is attributed to an imbalance in angiogenesis and apoptotic signaling. DEX alters mitochondrial function in muscle cells but nothing is known of DEX effects in endothelial cells that could explain i…
| 1 / 1 | Ongoing research grants |
| 9 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 20 / 13 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 33 / 23 | All research grants and scholarships |
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