Bachelor and Licenciated in Biological Sciences by the Institute of Biosciences USP, with Doctorate in Biochemistry by the Institute of Chemistry USP. Currently is a Full Professor of the Department of Physiology at IBUSP. Developed research projects with organisms of the family Trypanosomatidae, mainly Leishmania and Trypanosoma. Described DNA probes for identifying these organisms using various molecular targets and applying techniques such as hybridization and PCR. In basic molecular biology, studied the organization of RNA polymerase I promoters and the regulation of the expression of ribosomal RNA genes. Also studied the metabolism of Leishmania to understand the relation of the parasite with the host cell, with the objective of describing chemotherapeutic targets. Worked in the area of higher education, having acted in the coordination of the Molecular Sciences Course, (PRG-USP), a course dedicated to training scientists (2003 to 2008). Is a member of the Academy of Sciences of the State of São Paulo. A former member of the Board of Directors of the Brazilian Society of Protozoology (SBPz). Former member of the Board of the Brazilian Society for the Advancement of Science (SBPC) and was a member of the Board of Directors of SBPC (2017-2019/2019-2021). Also represented the SBPC at the National Animal Experimentation Control Council (CONCEA). Former President of `Brazilian Society of Protozoology. (Source: Lattes Curriculum)
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Leishmania is the protozoan responsible for leishmaniasis, a neglected disease that in Brazil causes about 100,000 new cases per year. In its life cycle, the parasite is found in the midgut of an insect or inside the phagolysosome in the macrophage of the mammalian host. The different stages of parasite life cycle influence the regulation of gene expression, which occurs at post-transcrip…
The biology of parasites belonging to Leishmania genus offers unique features as model for studying the host - pathogen interaction. Here we propose three sub-projects to study biochemical and physiological aspects of this interaction, primarily upon infe (AU)
The biology of parasites belonging to Leishmania genus offers unique features as model for studying the host - pathogen interaction. Here we propose three sub-projects to study biochemical and physiological aspects of this interaction, primarily upon infection of macrophages in the mammalian host. The objectives of the project are: To correlate the sub-cellular localization of arginase in…
(Only some records are available in English at this moment)
Leishmania is auxotrophic for amino acids and nutrients and has a specific transport for L-arginine mediated by amino acid porter-3 (AAP3) inpromastigote and amastigote forms. This transporter is encoded in two copies in the parasite's genome, one of which is regulated by the presence of the amino acid itself, externally or internally, in addition to pH, temperature and parasite arginase …
To evaluate the effects of sleep fractionation (FS), cytokine production and the profile of miRNAs involved in Th1 and Th2 responses in mice (C57BL / 6) infected by L. amazonensis, mainly miRNA-294, miRNA-721, miRNA -let7e, miRNA-30e and miRNA-302e and their roles in arginine metabolism.
Leishmania is an obligate intracellular parasite in the mammalian host, infecting phagocytic cells of the immune system. Inside the macrophage, the amastigote form is capable of subverting the hostile environment of the phagolysosome modulating host gene expression for its survival. L-arginine is a common substrate for both Nitric Oxide (NO) or polyamines production by macrophage enzymes …
(Only some records are available in English at this moment)
Metabolomic is emerging as an important tool to characterize macrophage phenotype, that, combined to genetic approaches, allows deciphering gene expression regulation in its ultimate phenotype, the metabolism. Metabolic rewiring during Leishmania infection was extensively studied in murine macrophages, but the differences to human immunology are increasingly being studied. Leishmania poss…
| 1 / 1 | Ongoing research grants |
| 15 / 8 | Completed research grants |
| 34 / 12 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 52 / 22 | All research grants and scholarships |
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CV Lattes
ORCID