Resumo
Primary ovarian insufficiency (POI) is defined as cessation of menstruation before the age of 40 years and diagnosis is confirmed by elevated serum FSH levels (>25IU/l), observed in <1% of the population. The disorder is clearly heterogeneous, with a wide spectrum of causes, namely cytogenetic, genic, infectious or iatrogenic, autoimmune and metabolic. Among 10 and 15% cases has an affect…