Abstract
Homologous recombination (HR) are one of double-strand break (DSB) repair pathways. BRCA1 and BRCA2, associated with the RAD51 protein, accumulates in DNA damage foci after signaling H2AX, a DNA damage marker that accumulates in lesion foci, associated to ATM/ATR pathway, leading to DNA repair. Topoisomerase III beta (TopoIII beta) removes HR intermediates before the segregation of chro…