Abstract
Prolylcarboxypeptidase (PRCP) is an enzyme specifically cleaving the last carboxy-terminal amino acid from substrates containing a penultimate proline. Its known peptide substrates des-Arg9-bradykinin, angiotensin II (AngII) and a-melanocortin stimulating hormone (aMSH) are linked to cardiovascular phenomenon. Working with PRCP knockout (PRCP-/-) mice while my doctoral thesis, I found tha…