CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
got BSc (2000) and Master degrees from the Federal University of Pelotas (2003), Ph.D. in Chemistry from the Federal University of Rio Grande do Sul (2007) and the Université Joseph Fourier (France) and postdoctoral fellow at Oak Ridge National Laboratory/USA (2008-2009). He was a researcher of the Brazilian Nanotechnology Laboratory where he lead the Nanomedicine and Nanotoxicology Division. Nowadays, he is a researcher of the Brazilian Synchrotron Laboratory (Sirius) where he is the head of the SoftBio Materials Division. It is registered as advisor in the Graduate Program of Chemistry and Physics at UNICAMP. He has experience in the field of chemistry and is involved in the development of synchrotron techniques that enable the study of the nano-bio interface.. (Source: Lattes Curriculum)
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Research works devoted to bioapplications of nanoparticles are usually carried out in liquid suspensions. However, aqueous nanoparticle suspensions present many sources of instabilities like premature drug leakage, denaturation/hydrolysis of loaded drugs/conjugated biomolecules, particle hydrolysis/etching, and aggregation or fusion depending on the nature of the nanoparticle. A common wa…
This project aims at achieving controlled association of varied colloids through either hydrophobic, electrostatic, or covalent bonds (or their combination) to tailor their characteristics, preferably in a reversible fashion. The envisaged functional colloidal objects span from surfactant and/or polymer aggregates, to nanoparticles of inorganic nature (mostly silica) or derived from renew…
Only a few nanoparticles (NPs) have passed FDA clinical trials for human use despite meaningful decades of in advances in NP drug-delivery systems and numerous published works. The proposal described here aims to understand the impact of protein presence on the ultimate location of nanoparticles inside mammalian cells. Silica particles containing fluorescent molecules such as Cy5, Alexa 6…
The proposal here described aims to synthesize fluorescent silica particles and coat them simultaneously with two distinct peptides using materials directing sequences to dock the functional biomolecules to the NP surface. The first is a RERERE-ending zwitterionic peptide, which will confer colloidal stability while avoiding protein corona formation around the particles. The second one is…
(Only some records are available in English at this moment)
Micro- and nanoplastics (MNPs) represent a current environmental challenge due to inadequate disposal in soil and aquatic environments, dispersing globally. These particles become environmental pollutants, being ingested by organisms in different ecosystems, including humans, with direct impacts on health and well-being. MNPs undergo degradation over time, especially through photodegradat…
Precision medicine aims to overcome traditional theranostic methods that often lack efficacy. However, the gap between laboratory research and practical applications stems from a limited understanding of interactions between nanoparticles (NPs) and biological systems. When exposed to biological fluids, NPs rapidly interact with biomolecules, forming an outer layer that plays a pivotal rol…
Protein corona is characterized by modulating the chemical surface of nanomaterials, from adsorbed proteins. This protein coating affects the action and efficiency of nanomaterials applied in nanomedicine. In view of this, it is necessary to understand how this coating affects the interaction and internalization of nanoparticles in human cells. In this work, silica nanoparticles (SiO2NPs)…
(Only some records are available in English at this moment)
The effectiveness of nanomedicines is strongly dependent on how they interact with the biological environment in which they were administered, since phenomena such as protein adsorption (protein corona), agglomeration or degradation of nanoparticles can occur, which, in turn, may affect their therapeutic performance. For this reason, it is essential to understand how these nanoparticles b…
Recent advances in nanomedicine aim to develop safe nanomaterials with high biological performance and drug load, distribution, and delivery capabilities. In this context, nanoparticles (NPs) with biodegradable properties can avoid unwanted scenarios, such as bioaccumulation, and be safely cleared by the immune system after degradation. Still, little is understood about the evolution of N…
Nanoparticles are promising structures for the development of diagnostic and therapeutic agents. On the other hand, despite the great potential, the current stage of nanoparticles application in the Biomedical field is followed by a therapeutic efficacy lower than 1% when inserted in vivo. This low efficiency has been pointed out as the result of an underestimated comprehension of the int…
(Only some records are available in English at this moment)
Antimicrobial resistance (AMR) is a critical global health challenge, driven by the overuse and misuse of antibiotics, leading to infections that are increasingly difficult to treat and posing serious risks to public health. Nanotechnology's application in medicine, or nanomedicine, has transformed the pharmaceutical and biotechnology industries, offering significant potential to address …
The escalating threat posed by emerging epidemics and the pervasive consequences of antimicrobial resistance (AMR) underscore the urgent need for innovative solutions. Recognized by the scientific community, nanobiotechnology emerges as a promising avenue in the battle against AMR. This PhD Thesis focuses on unraveling the intricate interplay between nanoparticles and Gram-negative bacter…
The immune system is sensitive to molecular and cellular structures with a spatial resolution of a few nm, which allows our immune system to detect and remove nanoparticles (NPs) and viruses from circulation. Nanomaterials have been built to avoid interaction with immune cells through, for example, hydrophilic coating agents. However, once nanomaterials are introduced into the body, they …
Cancer is known for its high mortality rates and for treatments which are often related to undesirable secondary effects. Therefore, the development of alternative methods for treating this disease is of paramount significance. Thus, a powerful strategy is the use of multifunctional nanoparticles (NPs), which have been extensively investigated in the recent years. NPs functionalized with …
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 7 / 7 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 21 / 21 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 8 | Completed scholarships abroad |
| 43 / 43 | All research grants and scholarships |
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