CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full professor at School of Pharmaceutical Sciences. Graduated at School of Dentistry of Ribeirao Preto from Universidade de São Paulo (1997), master's at Pharmacology from Universidade de São Paulo (2000) and PhD at Pharmacology from Universidade de São Paulo (2004). Has experience in Pharmacology, acting on the following subjects: reatividade vascular, injúria vascular, angiotensin ii, learning and carotida. (Source: Lattes Curriculum)
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The proposed application aims to consolidate a collaboration between two well-established research groups at the University of São Paulo, Brazil, and the University of Lyon, France. Here, we propose visits and exchange of faculty staff, which will allow us to develop qualitatively ongoing projects, provide training to postgraduate students through seminars and workshops, and plan new coll…
Extracellular Vesicles (EVs) have been related to a wide kind of function like developments in immunology, angiogenesis, and stem-cells biology, as well as several pathologies. EVs are bioactive organelles that can carry genetic information, lipids, proteins, and nucleic acids between cells, inducing many molecular functions associated with signalization and regulation of gene expression …
Bone remodelling is an active and dynamic process that relies on the correct balance between bone resorption by osteoclasts and bone deposition by osteoblasts. When the balance is lost such as in hormone changes situation, infectious process or trauma, an increased osteoclast function could lead to several skeletal pathologies. Using pharmacological tools, our research group evidenced the…
The proposed project aims to create a consortium to extend and strengthen the collaborative research between two well-established independently driven research groups from University of Sao Paulo and University of Glasgow. Through visits and exchanges of faculty staff, the consortium will promote the implementation of a critical mass joining resources and skills to conduct research projec…
(Only some records are available in English at this moment)
Bones, highly dynamic and active, are constantly remodeled to maintain the integrity and function of the bone tissue. This process, known as bone remodeling, is mediated by two main types of cells: osteoblasts, which produce bone tissue, and osteoclasts, which resorb bone, maintaining homeostasis. Intercellular communication in bone remodeling can occur through extracellular vesicles (EVs…
Osteosarcoma (OS) is a type of primary bone tumor that affects rapidly growing regions of the bone, which contributes to incidence and initial peak prevalence between 0 and 19 years of age. Treatment of OS consists of surgical resection and chemotherapy, which are not specific to the tumor cell. Therefore, new approaches are being studied in order to assist in the treatment, which include…
The periapical lesion stands out among odontogenic infections as a pathology with high global prevalence, and it may be associated with the tooth and its supporting structures. Its etiology is mainly related to the exposure of pulp tissues, and its progression can result in bone loss or the presence of abscesses. The formation of the periapical lesion results from the migration of bacteri…
(Only some records are available in English at this moment)
Osteosarcoma is a primary bone tumor that can affect children and adolescents, and has an invasive profile with high rates of metastasis. The main therapeutic approach for osteosarcoma is surgical resection which, when metastatic, has a 5-year survival of less than 30%. O-GlcNacylation is a post-translational modification that consists of the incorporation of O-GlcNac (O-linked-²-N-acetyl…
Osteoclasts are giant, multinucleated cells derived from the fusion of myeloid progenitors; their importance is due to the fact that they are the only cells in the human body responsible for the bone resorption function. To perform this function, osteoclasts undergo a series of structural and biochemical adaptations that demand a high energy load. Therefore, studies aimed at reducing oste…
Osteoporosis is a disorder alleviated by the progressive loss of bone mass and bone deterioration, leading to bone fragility and a predisposition to fracture. This disease has been seen as one of the most aging-related pathologies, especially in females due to the loss of estrogen after menopause, which has been tested as a worldwide health problem with considerable medical consequences. …
(Only some records are available in English at this moment)
Osteosarcoma (OS), is a primary bone tumor with prevalent occurrence in pediatric patients. Metastasis occurs in 80% of cases, primarily in the lungs, reducing survival to 20%. The process of metastasis in OS involves communication dynamics between OS cells and the tumor microenvironment, with exosomes released by these cells playing a central role. Exosomes encapsulate several molecules …
Osteoclasts are giant, multinucleated cells and the only cell in human organism with the bone resorption function. To perform this function, a series of morphological and biochemical adaptations that require a large amount of energy are necessary, which makes these cells rich in mitochondria, with an increase in mitochondrial mass during osteoclast differentiation and a high energy produc…
The O-GlcNAcylation is a post-translational modification consisting in linking O-linked-N-Acetylglucosamine (O-GlcNAc) to serine and threonine residues of nuclear and cytoplasmic proteins by the action of enzyme OGT. O-GlcNAcylation, analogously to the phosphorylation process, control the function of several target proteins. Many cell types can be target of O-GlcNAcylation, including the …
| 2 / 2 | Ongoing grants |
| 6 / 6 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 16 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 34 / 34 | All research grants and scholarships |
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