Abstract
Sickle Cell Anemia (SCA) is the most common monogenic hereditary disease, occurring predominantly among African Americans and has a heterogeneous distribution. Occurs due to the mutation in the sixth codon of the beta-globin gene (GAG GTG), which results in the substitution of glutamic acid for valine, in the beta-globin chain, resulting in the hemoglobin (Hb) S, with Physico-chemical fea…