CV Lattes
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
She holds a bachelor's degree in Physical Education from the Faculdade Integrada do Ceará (2005), a Specialization in Special Education from the Vale do Acaraú Estadual University (2007), a Master's Degree in Human Physiology from the Biomedical Sciences Institute of the University of São Paulo (2012) and a PhD in Human Physiology by the Institute of Biomedical Sciences of the University of São Paulo (2016). She is currently a postdoctoral fellow at the University of São Paulo. Has experience in the area of Physical Education and Human Physiology, with emphasis on Renal Physiology. (Source: Lattes Curriculum)
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The Renin Angiotensin System (RAS) is a regulator of the cardiovascular system and the electrolyte balance. A new component of the system has recently been identified, an alamandine, a heptapeptide generated by the catalytic action of the angiotensin-converting enzyme 2 or directly from Angiotensin-(1-7) [Ang-(1-7)]. Alamandine produces several physiological actions similar to those produ…
The actions of Ang-(1-7) in the kidney are not well understood: some admit they may be via receptor MAS and others via Mas plus AT1 and/or AT2. In our recent Master (see attached work), we demonstrated that in the proximal tubule Ang-(1-7), via MAS, has a biphasic effect: low dose inhibits the Na+/H+ exchanger (NHE3 isoform) increasing a lot the [Ca2+]i and high doses stimulates the excha…
Alamandine, a new component of the renin-angiotensin system has been recently identified and characterized and the Mas-related G-protein coupled receptor member D (MrgD) recognized as its receptor. Although cardioprotective effects of alamandine have been described, the significance of this peptide in renal function and kidney pathology, specifically in acute kidney injury (AKI) has not b…
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