graduate at Ciências Biológicas-Modalidade Médica from Universidade Federal de São Paulo (2001) and ph.d. at Microbiology from Universidade Federal de São Paulo (2007). Has experience in Biochemistry, focusing on Biochemetry of the Microorganisms (Source: Lattes Curriculum)
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At JP1, our group described many chromatin-associated proteins as well as more than 40 histone PTMs, differentially expressed in replicate versus non-replicative life forms of Trypanosoma cruzi. Classical eu- and heterochromatin regions are presented at their nucleus and changes dramatically during differentiation from epimastigotes to metacyclics (EàM). Traditionally, these chromatin reg…
Pathogenic trypanosomatids such as Leishmania spp. and Trypanosoma cruzi are the causative agents of leishmaniosis and Chagas disease, a group of neglected diseases endemic in the tropical and subtropical belt of the planet and the Americas, respectively. The therapeutic approaches against these diseases are largely unsatisfactory due to toxicity and emergence of resistance. Thus, new dru…
Trypanosoma cruzi is a unicellular eukaryote, a causative agent of Chagas disease that alternates between replicative and non-infective forms (epimastigotes and amastigotes) and non-replicative and infective forms (cellular and blood trypomastigotes). Differentiation between these forms is accompanied by differences in overall transcript levels and structural changes in chromatin. Several…
The nucleus is a complex organelle composed of nucleic acids and proteins in a tight relationship. The nuclear proteome, specially the chromatin proteome, plays a role in the regulation and management of genome that ultimately controls gene expression and cell phenotype. Many evidences demonstrate an important role of nucleus and chromatin in eukaryotic cell cycle control. The fibroblast …
Trypanosoma cruzi is a flagellate that causes Chagas Disease. It transits between vertebrate and invertebrate hosts, alternating constantly between replicative and infective forms. As a Trypanosomatide, it has particularities in its molecular biology, such as the transcription of large polycistronic regions. Specific promoter regions for each gene have not been described yet, indicating t…
Parasites will be subject to different metabolic backgrounds, such as severe metabolic stress by incubating them in deprivation of nutrients (PBS buffer) or under metabolic stress conditions with single carbon and energy sources for maintenance (PBS supplemented with glucose, proline, histidine or leucine). In parallel, parasites in different cell cycle stages will be obtained by cell sor…
In trypanosomes, it is general accepted that gene expression is mainly regulated by post-transcriptional mechanisms due to the lack of classical RNA Pol II promoters regions and polycistronic transcription. However, previous low-scale nuclear run-on experiments indicate that satellites genes have lower expression, suggesting some layer of regulation (Elias, Marques-Porto et al. 2001), and…
(Only some records are available in English at this moment)
To expand the comprehensive of Trypanosoma cruzi chromatin regulation, we proposed to take advantage of cutting-edge methodologies developed to recover proteins associated to a given locus. At this Master's project, we will explore the role of one or two chromatinassociated protein detected at the abovementioned methodology. Ideally, we will select proteins that were enriched at more than…
At JP1, our group described many chromatin-associated proteins as well as more than 40 histone PTMs differentially expressed in replicate versus non-replicative life forms in Trypanosoma cruzi. Classical eu- and heterochromatin regions are presented at their nucleus and changes dramatically during differentiation from epimastigotes to metacyclics (E-M). Traditionally, these chromatin regi…
Chromatin has an important function in essential cellular processes such as mitosis, transcription, replication, repair, among others. Fibroblast Growth Factor 2 (FGF2), despite inducing cell proliferation in several contexts, irreversibly inhibits the proliferation of mouse tumor cells (Y1 cell line) at the G2/M. To better understand the molecular mechanism induced by this factor, our gr…
(Only some records are available in English at this moment)
Despite being a growth factor, FGF2 has anti-proliferative and tumor suppressive functions in some cellular contexts. In Y1 murine adrenocortical carcinoma cell line, the FGF2 promotes G0-G1 transition but delays S-phase and permanently blocks cells in G2/M. To better understand the chromatin response to proliferative and anti-proliferative stimuli induced, respectively, by Fetal Bovine S…
Despite being a growth factor, FGF-2 has anti-proliferative and tumor suppressive functions in some cellular contexts. In a murine adrenocortical tumor cell line (lineage Y1), FGF-2 triggers an initial mitogenic response through ERK1/2, PKC and AKT signaling but results in a G2/M cell cycle arrest through RhoA/GTP-src signaling. Recently, we found transcription factors related to early-ge…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 10 / 7 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 20 / 17 | All research grants and scholarships |
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CV Lattes
ORCID