graduate at Ciências Biológicas-Modalidade Médica from Universidade Federal de São Paulo (2001) and ph.d. at Microbiology from Universidade Federal de São Paulo (2007). Has experience in Biochemistry, focusing on Biochemetry of the Microorganisms (Source: Lattes Curriculum)
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At JP1, our group described many chromatin-associated proteins as well as more than 40 histone PTMs, differentially expressed in replicate versus non-replicative life forms of Trypanosoma cruzi. Classical eu- and heterochromatin regions are presented at their nucleus and changes dramatically during differentiation from epimastigotes to metacyclics (EàM). Traditionally, these chromatin reg…
Pathogenic trypanosomatids such as Leishmania spp. and Trypanosoma cruzi are the causative agents of leishmaniosis and Chagas disease, a group of neglected diseases endemic in the tropical and subtropical belt of the planet and the Americas, respectively. The therapeutic approaches against these diseases are largely unsatisfactory due to toxicity and emergence of resistance. Thus, new dru…
Trypanosoma cruzi is a unicellular eukaryote, a causative agent of Chagas disease that alternates between replicative and non-infective forms (epimastigotes and amastigotes) and non-replicative and infective forms (cellular and blood trypomastigotes). Differentiation between these forms is accompanied by differences in overall transcript levels and structural changes in chromatin. Several…
The nucleus is a complex organelle composed of nucleic acids and proteins in a tight relationship. The nuclear proteome, specially the chromatin proteome, plays a role in the regulation and management of genome that ultimately controls gene expression and cell phenotype. Many evidences demonstrate an important role of nucleus and chromatin in eukaryotic cell cycle control. The fibroblast …
In trypanosomes, it is general accepted that gene expression is mainly regulated by post transcriptional mechanisms due to the lack of classical RNA Pol II promoters regions and policistronic transcription. However, previous low-scale run-on experiments indicate that satellites genes have lower expression, and a significant decrease in global transcription is observed when replicative for…
To expand the comprehensive of Trypanosoma cruzi chromatin regulation, we proposed to take advantage of cutting-edge methodologies developed to recover proteins associated to a given locus. At this Master's project, we will explore the role of one or two chromatinassociated protein detected at the abovementioned methodology. Ideally, we will select proteins that were enriched at more than…
At JP1, our group described many chromatin-associated proteins as well as more than 40 histone PTMs differentially expressed in replicate versus non-replicative life forms in Trypanosoma cruzi. Classical eu- and heterochromatin regions are presented at their nucleus and changes dramatically during differentiation from epimastigotes to metacyclics (E-M). Traditionally, these chromatin regi…
(Only some records are available in English at this moment)
Despite being a growth factor, Fibroblast Growth Factor (FGF) 2 has anti-proliferative and anti-tumor activities in some contexts. In adrenocortical mouse (Y1) lineage, FGF-2 delays S-phase progression and permanently blocks cells in the G2/M transition of the cell cycle, leading them to senescence. This project is the continuation of previous project (2015/04867-4) (carried out for 1 yea…
The fibroblast growth factor - 2 (FGF2) acts as a mitogenic agent, but in some cellular contexts, has antiproliferative functions and may be an important tumor suppressor. In mice tumor cells (lineage Y1), FGF2 acts by inhibiting the transition G0 / G1 to S and irreversibly blocks the cells in G2 / M. Quantitative proteomic analyzes performed by our group identified several differentially…
Some nuclear proteins are essential for the maintenance and regulation of the genome, transforming extracellular and intracellular signals into changes in gene expression and phenotype. In this project, we aim to analyze the nuclear proteome at different phases of the cell cycle and senescence of mouse tumor cells stimulated with FGF2. To this end, nuclear extracts will be systematically …
(Only some records are available in English at this moment)
Despite being a growth factor, FGF2 has anti-proliferative and tumor suppressive functions in some cellular contexts. In Y1 murine adrenocortical carcinoma cell line, the FGF2 promotes G0-G1 transition but delays S-phase and permanently blocks cells in G2/M. To better understand the chromatin response to proliferative and anti-proliferative stimuli induced, respectively, by Fetal Bovine S…
Despite being a growth factor, FGF-2 has anti-proliferative and tumor suppressive functions in some cellular contexts. In a murine adrenocortical tumor cell line (lineage Y1), FGF-2 triggers an initial mitogenic response through ERK1/2, PKC and AKT signaling but results in a G2/M cell cycle arrest through RhoA/GTP-src signaling. Recently, we found transcription factors related to early-ge…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 7 / 4 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 17 / 14 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 10 |
| Citations | 39 |
| Cit./Article | 3.9 |
| Data from Web of Science | |
DE LIMA, LOYZE P.; POUBEL, SALOE BISPO; YUAN, ZUO-FEI; ROSON, JULIANA NUNES; DE LUNA VITORINO, FRANCISCA NATHALIA; HOLETZ, FABIOLA BARBIERI; GARCIA, BENJAMIN A.; CHAGAS DA CUNHA, JULIA PINHEIRO. Improvements on the quantitative analysis of Trypanosoma cruzi histone post translational modifications: Study of changes in epigenetic marks through the parasite's metacyclogenesis and life cycle. JOURNAL OF PROTEOMICS, v. 225, APR 15 2020. Web of Science Citations: 0. (18/21785-0, 17/06104-3, 18/14432-3, 18/15553-9, 13/07467-1, 17/18344-9)
AZEVEDO, HATYLAS; PESSOA, GUILHERME CAVALCANTE; DE LUNA VITORINO, FRANCISCA NATHALIA; NSENGIMANA, JEREMIE; NEWTON-BISHOP, JULIA; REIS, EDUARDO MORAES; DA CUNHA, JULIA PINHEIRO CHAGAS; JASIULIONIS, MIRIAM GALVONAS. Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis. CLINICAL EPIGENETICS, v. 12, n. 1, AUG 24 2020. Web of Science Citations: 0. (18/15553-9, 18/20775-0, 18/04254-0, 14/13663-0, 17/18344-9)
LEANDRO DE JESUS, TERESA CRISTINA; NUNES, VINICIUS SANTANA; LOPES, MARIANA DE CAMARGO; MARTIL, DAIANA EVELIN; IWAI, LEO KEI; MORETTI, NILMAR SILVIO; MACHADO, FABRICIO CASTRO; DE LIMA-STEIN, MARIANA L.; THIEMANN, OTAVIO HENRIQUE; ELIAS, MARIA CAROLINA; et al. Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi. JOURNAL OF PROTEOME RESEARCH, v. 15, n. 6, p. 2039-2051, JUN 2016. Web of Science Citations: 12. (14/01577-2, 11/51973-3, 08/57910-0, 11/22619-7, 13/07467-1, 14/03714-7, 11/06087-5, 15/04867-4)
LIMA, ALEX R. J.; DE ARAUJO, CHRISTIANE B.; BISPO, SALOE; PATANE, JOSE; SILBER, ARIEL M.; ELIAS, M. CAROLINA; DA CUNHA, JULIA P. C.. Nucleosome landscape reflects phenotypic differences in Trypanosoma cruzi life forms. PLOS PATHOGENS, v. 17, n. 1, JAN 2021. Web of Science Citations: 0. (18/15553-9, 19/19690-3, 18/14432-3, 16/50050-2, 13/07467-1)
LIU, XIAOJING; COOPER, DANIEL E.; CLUNTUN, AHMAD A.; WARMOES, MARC O.; ZHAO, STEVEN; REID, MICHAEL A.; LIU, JUAN; LUND, PEDER J.; LOPES, MARIANA; GARCIA, BENJAMIN A.; et al. Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. Cell, v. 175, n. 2, p. 502+, OCT 4 2018. Web of Science Citations: 21. (17/15835-1)
SIDOLI, SIMONE; LOPES, MARIANA; LUND, PEDER J.; GOLDMAN, NAOMI; FASOLINO, MARIA; CORADIN, MARIEL; KULEJ, KATARZYNA; BHANU, V, NATARAJAN; VAHEDI, GOLNAZ; GARCIA, BENJAMIN A.. A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins. SCIENTIFIC REPORTS, v. 9, SEP 20 2019. Web of Science Citations: 0. (17/15835-1)
SIDOLI, SIMONE; KORI, YEKATERINA; LOPES, MARIANA; YUAN, ZUO-FEI; KIM, HEE JONG; KULEJ, KATARZYNA; JANSSEN, KEVIN A.; AGOSTO, LAURA M.; CHAGAS DA CUNHA, JULIA PINHEIRO; ANDREWS, ANDREW J.; et al. One minute analysis of 200 histone posttranslational modifications by direct injection mass spectrometry. Genome Research, v. 29, n. 6, p. 978-987, JUN 2019. Web of Science Citations: 1. (17/15835-1)
DE LUNA VITORINO, FRANCISCA NATHALIA; MONTONI, FABIO; MORENO, JAQUELINE NEVES; DE SOUZA, BRUNO FERREIRA; LOPES, MARIANA DE CAMARGO; CORDEIRO, BARBARA; FONSECA, CECILIA SELLA; GILMORE, JOSHUA M.; SARDIU, MIHAELA I.; REIS, MARCELO SILVA; et al. FGF2 Antiproliferative Stimulation Induces Proteomic Dynamic Changes and High Expression of FOSB and JUNB in K-Ras-Driven Mouse Tumor Cells. PROTEOMICS, v. 18, n. 17, SEP 2018. Web of Science Citations: 0. (11/22619-7, 13/07467-1)
LEANDRO DE JESUS, TERESA CRISTINA; CALDERANO, SIMONE GUEDES; DE LUNA VITORINO, FRANCISCA NATHALIA; LLANOS, RICARDO PARIONA; LOPES, MARIANA DE CAMARGO; DE ARAUJO, CHRISTIANE BEZERRA; THIEMANN, OTAVIO HENRIQUE; REIS, MARCELO DA SILVA; ELIAS, MARIA CAROLINA; CHAGAS DA CUNHA, JULIA PINHEIRO. Quantitative Proteomic Analysis of Replicative and Nonreplicative Forms Reveals Important Insights into Chromatin Biology of Trypanosoma cruzi. MOLECULAR & CELLULAR PROTEOMICS, v. 16, n. 1, p. 23-38, JAN 2017. Web of Science Citations: 5. (13/07467-1, 11/22619-7)
CV Lattes
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