Abstract
The severity of Paracoccidioidomycosis (PCM), systemic granulomatous disease, caused by fungus Paracoccidioides brasiliensis, is related to the properties of the infectious agent, as well as the mechanisms of host defense. The resolution of the infection involves the production of T helper (Th) 1 cytokines (IL-12, IL-18 and IFN-³). Importantly, the development of an appropriate immune res…