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Luis Felipe Santos Mendes

CV Lattes

Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Luis Felipe Santos Mendes studied Biomolecular Physics in the Physics Department of the University of São Paulo and graduated in 2011. For his work with distance measurements using continuous-wave and pulsed electron magnetic resonance applied to proteins involved in calcium-response homeostasis, he was granted and spent three months in the Gunnar Jeschke lab at the ETH-Zurich. As a PhD student in the Faculty of Philosophy, Science and Letters of the University of São Paulo, he was inserted in a structural biology project involving a multitask protein called GRASP, which work as key factors in the Golgi biogenesis and Unconventional Secretory Pathways. During the PhD, he spent one year as guest student in the New Biochemistry Department of the University of Oxford-UK (supervision of Prof. Dr. Anthony Watts) and one month in the Chemistry Department of NCSU (guidance of Prof. Dr. Alex I. Smirnov). He currently works as a postdoctoral fellow at the Physics Department of the University of São Paulo and seeks to elucidate the mechanism of action of soluble (GRASP55 and 65) and integral membrane (p24/TMED family) proteins in the early secretory pathway (linked to the Center for Research in Inflammatory Diseases). Inside this main project, we also started to seek for a explanation of a Metazoa-specific protein paralogy (using GRASP55/GRASP65 as a model case) by going back to the past using Protein Ancestor Sequence Reconstruction. He has experience in classical molecular biology techniques (cloning, subcloning, mutant construction, expression and purification of heterologous soluble/membrane proteins) and a variety of spectroscopic techniques, with special emphasis on Circular Dichroism (conventional and synchrotron-radiation), fluorescence (steady-state and lifetime techniques) and Magnetic Resonances (electronic and nuclear). (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

MENDES, LUIS F. S.; FONTANA, NATALIA A.; OLIVEIRA, CAROLINA G.; FREIRE, MARJORIE C. L. C.; LOPES, JOSE L. S.; MELO, FERNANDO A.; COSTA-FILHO, ANTONIO J.. The GRASP domain in golgi reassembly and stacking proteins: differences and similarities between lower and higher Eukaryotes. FEBS Journal, v. 286, n. 17, p. 3340-3358, . Web of Science Citations: 2. (16/23863-2, 12/20367-3, 09/53989-4, 17/24669-8, 15/50366-7)

MENDES, LUIS FELIPE S.; BATISTA, MARIANA R. B.; JUDGE, PETER J.; WATTS, ANTHONY; REDFIELD, CHRISTINA; COSTA-FILHO, ANTONIO J.. Conformational flexibility of GRASPs and their constituent PDZ subdomains reveals structural basis of their promiscuous interactome. FEBS Journal, . Web of Science Citations: 0. (12/20367-3, 15/50366-7, 16/09676-5, 17/24669-8)

MENDES, LUIS F. S.; GARCIA, ASSUERO F.; KUMAGAI, PATRICIA S.; DE MORAIS, FABIO R.; MELO, FERNANDO A.; KMETZSCH, LIVIA; VAINSTEIN, MARILENE H.; RODRIGUES, MARCIO L.; COSTA-FILHO, ANTONIO J.. New structural insights into Golgi Reassembly and Stacking Protein (GRASP) in solution. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 6. (12/13309-7, 12/20367-3)

ALVAREZ, NATALIA; MENDES, LUIS F. S.; GABRIELA KRAMER, M.; TORRE, MARIA H.; COSTA-FILHO, ANTONIO J.; ELLENA, JAVIER; FACCHIN, GIANELLA. Development of copper(II)-diimine-iminodiacetate mixed ligand complexes as potential antitumor agents. Inorganica Chimica Acta, v. 483, p. 61-70, . Web of Science Citations: 11. (12/13309-7, 17/24669-8)

MENDES, LUIS F. S.; BASSO, LUIS G. M.; KUMAGAI, PATRICIA S.; FONSECA-MALDONADO, RAQUEL; COSTA-FILHO, ANTONIO J.. Disorder-to-order transitions in the molten globule-like Golgi Reassembly and Stacking Protein. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1862, n. 4, p. 855-865, . Web of Science Citations: 4. (12/13309-7, 14/00206-0, 15/18390-5, 11/21767-2, 12/20367-3, 15/50366-7)

FONTANA, N. A.; FONSECA-MALDONADO, R.; MENDES, L. F. S.; MELEIRO, L. P.; COSTA-FILHO, A. J.. The yeast GRASP Grh1 displays a high polypeptide backbone mobility along with an amyloidogenic behavior. SCIENTIFIC REPORTS, v. 8, . Web of Science Citations: 3. (12/13309-7, 16/23863-2, 16/09676-5, 15/18390-5, 15/50366-7, 12/20367-3)

MICHELETTO, MARIANA C.; MENDES, LUIS F. S.; BASSO, LUIS G. M.; FONSECA-MALDONADO, RAQUEL G.; COSTA-FILHO, ANTONIO J.. Lipid membranes and acyl-CoA esters promote opposing effects on acyl-CoA binding protein structure and stability. International Journal of Biological Macromolecules, v. 102, p. 284-293, . Web of Science Citations: 2. (12/13309-7, 14/00206-0, 15/18390-5, 15/50366-7)

THIRUPATHI REDDY, S.; SANTOS MENDES, LUIS FELIPE; FONTANA, NATALIA APARECIDA; COSTA-FILHO, ANTONIO JOSE. Exploring structural aspects of the human Golgi matrix protein GRASP55 in solution. International Journal of Biological Macromolecules, v. 135, p. 481-489, . Web of Science Citations: 0. (16/23863-2, 17/12146-0, 17/24669-8, 15/16812-0, 15/50366-7, 12/20367-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MENDES, Luis Felipe Santos. Caracterização estrutural e dinâmica da proteína de estruturação e compactação do complexo de Golgi (GRASP) em solução. 2018. Tese (Doutorado) – Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto.

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