Abstract
Snakebites are a public health problem, concerning tropical and subtropical regions, rural and poor areas of Latin America, Africa, Asia and Oceania. In Brazil, Bothrops and Crotalus genera account for about 98% of reported snakebites. Bothropic envenomation is characterized by intense local myonecrosis (and other local effects) inefficiently neutralized by antivenom, which can induce sli…