CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Has a solid academic background and an extensive, diverse career in chemistry and molecular biology. With a Bachelor's degree in Chemistry and Industrial Chemistry from the University of São Paulo, they furthered his education with a Master's and PhD in Biological Sciences (Molecular Biology) from the Federal University of São Paulo, building a strong scientific foundation for his research. The postdoctoral work at the University of São Paulo and the role as an associate researcher at the Fred Hutchinson Cancer Research Center reflect his high qualifications and international recognition. During his time at Fred Hutchinson (2004-2009), his focus on strategies and applications of clinical proteomics in various types of cancer demonstrates expertise in advanced technologies for molecular detection and tumor biomarkers, critical areas for precision oncology. The position as a visiting researcher at Cornell University (2018-2019), where they worked on post-translational modifications in proteins, highlights his ability to work at the forefront of knowledge regarding complex biological processes. His experience in protein chemistry and proteomics applied to biological problems is widely acknowledged, as evidenced by publications in high-impact international journals and frequent presentations at national and international conferences. Additionally, his role as a reviewer for scientific journals in the field underscores his recognition by the academic community. His current focus on clinical applications of proteomics in cancer, emphasizing protein alterations and molecular signatures in tumor progression, showcases his significant contribution to translational research and advancements in cancer treatment. (Source: Lattes Curriculum)
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Proteomic applications in biomolecular sciences have been expanding consistently, due to the maturity of the approach in terms of sensitivity, reproducibility and quantitative capacity, following the trend of other "omics" areas. Currently, the USP campus in Ribeirão Preto is not supported by a platform capable of exploring complex proteomic studies in basic or clinical scientific researc…
Cell biology has studied the organization, structure and function of cells in different tissues for centuries. Important advances have taken place in this area, mainly related to the technological development that today allows, for example, the diagnosis and sub classification of tumors using molecular markers evaluated by the most diverse strategies. However, identification of the molecu…
COVID-19 represents an unprecedented pandemic and tends to become endemic and recurrent due to the characteristics of the SARS-CoV-2 virus and its mutations. With the continuous increase in the number of cases worldwide, the lack of vaccines or effective treatments, the health system is significantly impacted by the high demand for resources to diagnose and treat patients. To understand t…
Cancer is a leading cause of death worldwide and aging ls considered one of the most important risk factors for cancer. Aging is characterized by chronic low-grade inflammation and oxidant damage, which lead to endothelial senescence and disruption of vascular function. Inflammatory mediators released from senescent endothelial cells contribute to cancer by promoting mutations in neighbor…
(Only some records are available in English at this moment)
Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 oncoprotein, with constitutive activation of its tyrosine kinase activity and the neoplastic transformation of hematopoietic stem cells. The development of tyrosine kinase inhibitors (TKIs) specific for BCR-ABL1, such as imatinib mesylate, represented a breakthrough in the treatment of CML. However, therapeuti…
The steady increase in non-small cell lung carcinoma (NSCLC) incidence among never-smoked and those exposed to air atmospheric pollutants, specifically fine particulate matter (PM2.5), is a significant cause for concern. Considering that lung cancer, particularly NSCLC, is among the most prevalent cancers worldwide with a low survival rate, it's necessary to comprehend the molecular mecha…
Cancer is a set of multifactorial diseases characterized by the uncontrolled proliferation of cells that invade tissues and organs. The acquisition of the necessary competencies for this involves the occurrence of various genomic and proteomic alterations, which profoundly modify the functioning of the cell and its relationship with the microenvironment in which it is inserted. Among thes…
(Only some records are available in English at this moment)
Cancer is a set of multifactorial diseases that generate disorderly growing cells, forming malignant tumors that can invade adjacent tissues or distant organs through the process of metastasis, which is ultimately responsible for lethality of these diseases. One of the molecular mechanisms that occurs during metastasis is the epithelial-mesenchymal transition (EMT). EMT is regulated for m…
Cancer is a set of multifactorial diseases that generate disordered cell growth, forming malignant tumors that can invade adjacent tissues or distant organs, through the process of metastasis, which is responsible for the lethality of the disease. One of the molecular mechanisms that occurs during metastasis is the epithelial-mesenchymal transition (EMT). EMT is controlled by multiple fac…
(Only some records are available in English at this moment)
Pancreatic cancer (PanCa) is among the most aggressive adenocarcinomas and difficult to diagnose. Since it develops silently and exhibits high genetic complexity, a reliable diagnosis is only possible when metastasis have already spread to secondary sites. Unfortunately, the two biomarkers for PanCa detection (carbohydrate antigen 19-9 and carcinoembryonic antigen) do not allow a reliable…
| 2 / 2 | Ongoing grants |
| 7 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 16 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 31 / 25 | All research grants and scholarships |
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