Manuela Berto Pucca
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Biomedicina from Centro Universitário de Araraquara (2004), master's at Imunologia Básica e Aplicada (CAPES 7) from USP - Faculdade de Medicina de Ribeirão Preto (2009) and doctorate at Imunologia Básica e Aplicada (CAPES 7) from USP - Faculdade de Medicina de Ribeirão Preto (2012). Has experience in Pharmacy, acting on the following subjects: scfv, phage display, tityus serrulatus, bothrops sp. and bee venom. (Source: Lattes Curriculum)
- Study of the toxins Ts6 e Ts15 from the scorpion Tityus serrulatus as potential therapeutic drugs for the treatment of autoimmune diseases, BP.PD
Abstract
The potassium channel subtype Kv1.3 has been focus of scientific research, since it can be used as target for induction of T cell suppression since 1984. The mechanism by which Kv1.3 channels trigger immunossupression is directly related to intracellular calcium signaling. Therefore, in the absence of sufficient Ca2+ influx, the T cell activation, proliferation and effector functions ar...
- Electrophysiological characterization of Tityus serrulatus venom toxins Ts3, Ts4, Ts6, Ts8, Ts15 and TS venom peptide 7: looking for new desired drugs, BE.EP.PD
Abstract
In recent years, attention was focused on biologically active peptides isolated from animal venoms and their physiological relevance. This movement was strengthened by the increased interest of pharmaceutical industries in the use of such molecules as drug leads. Among the biologically active molecules of greatest biotechnological potential are animal toxins, including scorpion peptides...
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 2 / 2 | All Scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 139 |
| Cit./Article | 11.6 |
| Data from Web of Science | |
PUCCA, MANUELA BERTO; CEMI, FELIPE AUGUSTO; PINHEIRO JUNIOR, ERNESTO LOPES; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FEMANDA GOBBI; CORDEIRO, FRANCIELLE ALMEIDA; LONGHIM, HELOISA TAVONI; CREMONEZ, CAROLINE MARRONI; OLIVEIRA, GUILHERME HONDA; ARANTES, ELIANE CANDIANI. Tityus serrulatus venom - A lethal cocktail. Toxicon, v. 108, p. 272-284, DEC 15 2015. Web of Science Citations: 27. (14/07824-1, 11/12317-3, 12/12954-6, 12/13590-8)
CERNI, FELIPE AUGUSTO; PUCCA, MANUELA BERTO; AMORIM, FERNANDA GOBBI; FIGUEIREDO BORDON, KARLA DE CASTRO; ECHTERBILLE, JULIEN; QUINTON, LOIC; DE PAUW, EDWIN; PEIGNEUR, STEVE; TYTGAT, JAN; ARANTES, ELIANE CANDIANI. Isolation and characterization of Ts19 Fragment II, a new long-chain potassium channel toxin from Tityus serrulatus venom. Peptides, v. 80, p. 9-17, JUN 2016. Web of Science Citations: 11. (13/21342-7, 13/21329-0, 13/26083-0, 11/12317-3, 12/13590-8)
LODOVICHO, MARINA E.; COSTA, TASSIA R.; BERNARDES, CAROLINA P.; MENALDO, DANILO L.; ZOCCAL, KARINA F.; CARONE, SANTE E.; ROSA, JOSE C.; PUCCA, MANUELA B.; CERNI, FELIPE A.; ARANTES, ELIANE C.; et al. Investigating possible biological targets of Bj-CRP, the first cysteine-rich secretory protein (CRISP) isolated from Bothrops jararaca snake venom. Toxicology Letters, v. 265, p. 156-169, JAN 4 2017. Web of Science Citations: 10. (11/23236-4, 12/12954-6, 12/13590-8)
BOLDRINI-FRANCA, JOHARA; COLOGNA, CAMILA TAKENO; PUCCA, MANUELA BERTO; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDO GOBBI; PINO ANJOLETTE, FERNANDO ANTONIO; CORDEIRO, FRANCIELLE ALMEIDA; WIEZEL, GISELE ADRIANO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; et al. Minor snake venom proteins: Structure, function and potential applications. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 4, p. 824-838, APR 2017. Web of Science Citations: 18. (15/16714-8, 11/23236-4, 12/13590-8, 14/15644-3, 14/06170-8, 12/12954-6, 13/26200-6, 13/26619-7, 11/12317-3)
PUCCA, MANUELA B.; PEIGNEUR, STEVE; COLOGNA, CAMILA T.; CERNI, FELIPE A.; ZOCCAL, KARINA F.; BORDON, KARLA DE C. F.; FACCIOLI, LUCIA H.; TYTGAT, JAN; ARANTES, ELIANE C.. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages. Biochimie, v. 115, p. 8-16, AUG 2015. Web of Science Citations: 12. (13/26200-6, 13/21329-0, 09/07169-5, 14/03332-7, 13/21342-7)
PUCCA, MANUELA BERTO; AMORIM, FERNANDA GOBBI; CERNI, FELIPE ATIGUSTO; FIGUEIREDO BORDON, KARLA DE CASTRO; CARDOSO, IARA AIME; PINO ANJOLETTE, FERNANDO ANTONIO; ARANTES, ELIANE CANDIANI. Influence of post-starvation extraction time and prey-specific diet in Tityus serrulatus scorpion venom composition and hyaluronidase activity. Toxicon, v. 90, p. 326-336, NOV 2014. Web of Science Citations: 19. (11/12317-3, 12/12954-6, 12/13590-8)
PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; CORDEIRO, FRANCIELLE ALMEIDA; PEIGNEUR, STEVE; CUNHA, THIAGO MATTAR; TYTGAT, JAN; ARANTES, ELIANE CANDIANI. Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo. Toxicon, v. 119, p. 244-252, SEP 1 2016. Web of Science Citations: 7. (13/21329-0, 12/13590-8, 13/21342-7, 12/12954-6, 13/08216-2)
CERNI, FELIPE AUGUSTO; PUCCA, MANUELA BERTO; ZOCCAL, KARINA FURLANI; FRANTZ, FABIANI GAI; FACCIOLI, LUCIA HELENA; ARANTES, ELIANE CANDIANI. Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production. Toxicon, v. 134, p. 18-25, AUG 2017. Web of Science Citations: 2. (13/21329-0, 14/07125-6, 13/21342-7, 14/03332-7)
PESSENDA, GABRIELA; SILVA, LUCIANO C.; CAMPOS, LUCAS B.; PACELLO, ELENICE M.; PUCCA, MANUELA B.; MARTINEZ, EDSON Z.; BARBOSA, JOSE E.. Human scFv antibodies (Afribumabs) against Africanized bee venom: Advances in melittin recognition. Toxicon, v. 112, p. 59-67, MAR 15 2016. Web of Science Citations: 6. (12/12954-6)
PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; ZOCCAL, KARINA FURLANI; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDA GOBBI; PEIGNEUR, STEVE; VRIENS, KIM; THEVISSEN, KARIN; ANGELO CAMMUE, BRUNO PHILIPPE; et al. Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for proline-free ACE-inhibitors. Peptides, v. 82, p. 44-51, AUG 2016. Web of Science Citations: 5. (14/03332-7, 13/06380-0, 12/13590-8, 13/21329-0, 13/21342-7, 14/07125-6, 11/12317-3)
PUCCA, MANUELA B.; BERTOLINI, THAIS B.; CERNI, FELIPE A.; BORDON, KARLA C. F.; PEIGNEUR, STEVE; TYTGAT, JAN; BONATO, VANIA L.; ARANTES, ELIANE C.. Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K+ channel pattern in T cells. Immunology, v. 147, n. 2, p. 240-250, FEB 2016. Web of Science Citations: 6. (13/21329-0, 13/21342-7, 12/12954-6, 12/13590-8)
PUCCA, MANUELA B.; CERNI, FELIPE A.; PEIGNEUR, STEVE; BORDON, KARLA C. F.; TYTGAT, JAN; ARANTES, ELIANE C.. Revealing the Function and the Structural Model of Ts4: Insights into the ``Non-Toxic{''} Toxin from Tityus serrulatus Venom. TOXINS, v. 7, n. 7, p. 2534-2550, JUL 2015. Web of Science Citations: 16. (13/21329-0, 13/21342-7)