CV Lattes
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ORCID
Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Biomedicina from Centro Universitário de Araraquara (2004), master's at Imunologia Básica e Aplicada (CAPES 7) from USP - Faculdade de Medicina de Ribeirão Preto (2009) and doctorate at Imunologia Básica e Aplicada (CAPES 7) from USP - Faculdade de Medicina de Ribeirão Preto (2012). Has experience in Pharmacy, acting on the following subjects: scfv, phage display, tityus serrulatus, bothrops sp. and bee venom. (Source: Lattes Curriculum)
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The potassium channel subtype Kv1.3 has been focus of scientific research, since it can be used as target for induction of T cell suppression since 1984. The mechanism by which Kv1.3 channels trigger immunossupression is directly related to intracellular calcium signaling. Therefore, in the absence of sufficient Ca2+ influx, the T cell activation, proliferation and effector functions are …
In recent years, attention was focused on biologically active peptides isolated from animal venoms and their physiological relevance. This movement was strengthened by the increased interest of pharmaceutical industries in the use of such molecules as drug leads. Among the biologically active molecules of greatest biotechnological potential are animal toxins, including scorpion peptides.T…
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
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PESSENDA, GABRIELA; SILVA, LUCIANO C.; CAMPOS, LUCAS B.; PACELLO, ELENICE M.; PUCCA, MANUELA B.; MARTINEZ, EDSON Z.; BARBOSA, JOSE E.. Human scFv antibodies (Afribumabs) against Africanized bee venom: Advances in melittin recognition. Toxicon, v. 112, p. 59-67, MAR 15 2016. (12/12954-6)
PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; ZOCCAL, KARINA FURLANI; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDA GOBBI; PEIGNEUR, STEVE; VRIENS, KIM; THEVISSEN, KARIN; ANGELO CAMMUE, BRUNO PHILIPPE; et al. Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for proline-free ACE-inhibitors. Peptides, v. 82, p. 44-51, AUG 2016. (13/21342-7, 11/12317-3, 14/03332-7, 13/06380-0, 14/07125-6, 12/13590-8, 13/21329-0)
PUCCA, MANUELA B.; BERTOLINI, THAIS B.; CERNI, FELIPE A.; BORDON, KARLA C. F.; PEIGNEUR, STEVE; TYTGAT, JAN; BONATO, VANIA L.; ARANTES, ELIANE C.. Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K+ channel pattern in T cells. Immunology, v. 147, n. 2, p. 240-250, FEB 2016. (13/21329-0, 13/21342-7, 12/13590-8, 12/12954-6)
PUCCA, MANUELA B.; CERNI, FELIPE A.; PEIGNEUR, STEVE; BORDON, KARLA C. F.; TYTGAT, JAN; ARANTES, ELIANE C.. Revealing the Function and the Structural Model of Ts4: Insights into the ``Non-Toxic{''} Toxin from Tityus serrulatus Venom. TOXINS, v. 7, n. 7, p. 2534-2550, JUL 2015. (13/21329-0, 13/21342-7)
CERNI, FELIPE AUGUSTO; PUCCA, MANUELA BERTO; ZOCCAL, KARINA FURLANI; FRANTZ, FABIANI GAI; FACCIOLI, LUCIA HELENA; ARANTES, ELIANE CANDIANI. Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production. Toxicon, v. 134, p. 18-25, AUG 2017. (13/21329-0, 14/07125-6, 13/21342-7, 14/03332-7)
PUCCA, MANUELA BERTO; CEMI, FELIPE AUGUSTO; PINHEIRO JUNIOR, ERNESTO LOPES; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FEMANDA GOBBI; CORDEIRO, FRANCIELLE ALMEIDA; LONGHIM, HELOISA TAVONI; CREMONEZ, CAROLINE MARRONI; OLIVEIRA, GUILHERME HONDA; ARANTES, ELIANE CANDIANI. Tityus serrulatus venom - A lethal cocktail. Toxicon, v. 108, p. 272-284, DEC 15 2015. (14/07824-1, 12/13590-8, 12/12954-6, 11/12317-3)
CERNI, FELIPE AUGUSTO; PUCCA, MANUELA BERTO; AMORIM, FERNANDA GOBBI; FIGUEIREDO BORDON, KARLA DE CASTRO; ECHTERBILLE, JULIEN; QUINTON, LOIC; DE PAUW, EDWIN; PEIGNEUR, STEVE; TYTGAT, JAN; ARANTES, ELIANE CANDIANI. Isolation and characterization of Ts19 Fragment II, a new long-chain potassium channel toxin from Tityus serrulatus venom. Peptides, v. 80, p. 9-17, JUN 2016. (13/21342-7, 11/12317-3, 13/26083-0, 12/13590-8, 13/21329-0)
PUCCA, MANUELA B.; PEIGNEUR, STEVE; COLOGNA, CAMILA T.; CERNI, FELIPE A.; ZOCCAL, KARINA F.; BORDON, KARLA DE C. F.; FACCIOLI, LUCIA H.; TYTGAT, JAN; ARANTES, ELIANE C.. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages. Biochimie, v. 115, p. 8-16, AUG 2015. (13/21342-7, 14/03332-7, 09/07169-5, 13/21329-0, 13/26200-6)
PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; CORDEIRO, FRANCIELLE ALMEIDA; PEIGNEUR, STEVE; CUNHA, THIAGO MATTAR; TYTGAT, JAN; ARANTES, ELIANE CANDIANI. Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo. Toxicon, v. 119, p. 244-252, SEP 1 2016. (13/08216-2, 13/21342-7, 12/13590-8, 13/21329-0, 12/12954-6)
PUCCA, MANUELA BERTO; AMORIM, FERNANDA GOBBI; CERNI, FELIPE ATIGUSTO; FIGUEIREDO BORDON, KARLA DE CASTRO; CARDOSO, IARA AIME; PINO ANJOLETTE, FERNANDO ANTONIO; ARANTES, ELIANE CANDIANI. Influence of post-starvation extraction time and prey-specific diet in Tityus serrulatus scorpion venom composition and hyaluronidase activity. Toxicon, v. 90, p. 326-336, NOV 2014. (12/13590-8, 12/12954-6, 11/12317-3)
CERNI, FELIPE A.; PUCCA, MANUELA B.; PEIGNEUR, STEVE; CREMONEZ, CAROLINE M.; BORDON, KARLA C. F.; TYTGAT, JAN; ARANTES, ELIANE C.. Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure. TOXINS, v. 6, n. 3, p. 892-913, MAR 2014. Web of Science Citations: 23. (12/13590-8, 08/10761-0)
PUCCA, MANUELA B.; BERTOLINI, THAIS B.; CERNI, FELIPE A.; BORDON, KARLA C. F.; PEIGNEUR, STEVE; TYTGAT, JAN; BONATO, VANIA L.; ARANTES, ELIANE C.. Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K+ channel pattern in T cells. Immunology, v. 147, n. 2, p. 240-250, FEB 2016. Web of Science Citations: 6. (13/21342-7, 12/13590-8, 13/21329-0, 12/12954-6)
PUCCA, MANUELA B.; CERNI, FELIPE A.; PEIGNEUR, STEVE; BORDON, KARLA C. F.; TYTGAT, JAN; ARANTES, ELIANE C.. Revealing the Function and the Structural Model of Ts4: Insights into the ``Non-Toxic{''} Toxin from Tityus serrulatus Venom. TOXINS, v. 7, n. 7, p. 2534-2550, JUL 2015. Web of Science Citations: 16. (13/21342-7, 13/21329-0)
DE OLIVEIRA, ISADORA SOUSA; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; IMAI CARONE, SANTE EMMANUEL; BOLDRINI-FRANCA, JOHARA; PUCCA, MANUELA BERTO; ZOCCAL, KARMA FURLANI; FACCIOLI, LUCIA HELENA; SAMPAIO, SUELY VILELA; ROSA, JOSE CESAR; et al. Global proteomic and functional analysis of Crotalus durissus collilineatus individual venom variation and its impact on envenoming. JOURNAL OF PROTEOMICS, v. 191, n. SI, p. 153-165, JAN 16 2019. Web of Science Citations: 5. (14/16182-3, 14/03332-7, 11/23236-4)
CERNI, FELIPE AUGUSTO; PUCCA, MANUELA BERTO; ZOCCAL, KARINA FURLANI; FRANTZ, FABIANI GAI; FACCIOLI, LUCIA HELENA; ARANTES, ELIANE CANDIANI. Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production. Toxicon, v. 134, p. 18-25, AUG 2017. Web of Science Citations: 2. (13/21342-7, 14/07125-6, 13/21329-0, 14/03332-7)
PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; CORDEIRO, FRANCIELLE ALMEIDA; PEIGNEUR, STEVE; CUNHA, THIAGO MATTAR; TYTGAT, JAN; ARANTES, ELIANE CANDIANI. Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo. Toxicon, v. 119, p. 244-252, SEP 1 2016. Web of Science Citations: 7. (12/12954-6, 13/21342-7, 13/08216-2, 12/13590-8, 13/21329-0)
PUCCA, MANUELA B.; PEIGNEUR, STEVE; COLOGNA, CAMILA T.; CERNI, FELIPE A.; ZOCCAL, KARINA F.; BORDON, KARLA DE C. F.; FACCIOLI, LUCIA H.; TYTGAT, JAN; ARANTES, ELIANE C.. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages. Biochimie, v. 115, p. 8-16, AUG 2015. Web of Science Citations: 12. (13/21342-7, 14/03332-7, 13/26200-6, 09/07169-5, 13/21329-0)
ABREU, CAIO B.; BORDON, KARLA C. F.; CERNI, FELIPE A.; OLIVEIRA, ISADORA S.; BALENZUELA, CARLA; ALEXANDRE-SILVA, GABRIEL M.; ZOCCAL, KARINA F.; REIS, MOUZARLLEM B.; WIEZEL, GISELE A.; PEIGNEUR, STEVE; et al. Pioneering Study onRhopalurus crassicaudaScorpion Venom: Isolation and Characterization of the Major Toxin and Hyaluronidase. FRONTIERS IN IMMUNOLOGY, v. 11, AUG 20 2020. Web of Science Citations: 0. (17/00586-6, 16/04761-4, 17/04724-4, 17/03580-9, 19/10173-6, 17/14035-1, 18/21233-7)
PUCCA, MANUELA B.; CERNI, FELIPE A.; OLIVEIRA, ISADORA S.; JENKINS, TIMOTHY P.; ARGEMI, LIDIA; SORENSEN, CHRISTOFFER V.; AHMADI, SHIRIN; BARBOSA, JOSE E.; LAUSTSEN, ANDREAS H.. Bee Updated: Current Knowledge on Bee Venom and Bee Envenoming Therapy. FRONTIERS IN IMMUNOLOGY, v. 10, SEP 6 2019. Web of Science Citations: 3. (17/04724-4, 18/14158-9, 17/14035-1, 17/03580-9, 18/21233-7)
BOLDRINI-FRANCA, JOHARA; COLOGNA, CAMILA TAKENO; PUCCA, MANUELA BERTO; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDO GOBBI; PINO ANJOLETTE, FERNANDO ANTONIO; CORDEIRO, FRANCIELLE ALMEIDA; WIEZEL, GISELE ADRIANO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; et al. Minor snake venom proteins: Structure, function and potential applications. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 4, p. 824-838, APR 2017. Web of Science Citations: 18. (12/12954-6, 14/06170-8, 13/26619-7, 13/26200-6, 14/15644-3, 15/16714-8, 11/23236-4, 12/13590-8, 11/12317-3)