CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Instituto Nacional de Farmacologia (INFAR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas Modalidade Médica from Universidade Federal de São Paulo (1984), master's at Biochemistry from Universidade Federal de São Paulo (1989), master's at Multidisciplinary from Pontifícia Universidade Católica de São Paulo (2001) and doctorate at Biochemistry from Universidade Federal de São Paulo (1996). Has experience in General Biology, acting on the following subjects: heparan sulfate, cerebelo, glycosaminoglycan, neurônio and proteoglycan. (Source: Lattes Curriculum)
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The new coronavirus SARS-CoV-2 emerged in December 2019, in China, and disseminated to several countries, causing an acute respiratory disease called COVID-19 (Coronavirus disease 2019). COVID-19 can evolve to severe respiratory infections resulting in high mortality index for people over 60 years of age or people that chronic diseases, such as diabetes, cardiac, and vascular diseases. CO…
The concept of organ-on-a-chip refers to different types of in vitro modeling or reproduction of tissues and organs by combining cells and biocompatible material. This approach has become an attractive alternative for various studies, such as drug testing. The initial push was the worldwide effort to reduce the number of lab animals used in research, by the application of the 3R's - repla…
The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Pr…
(Only some records are available in English at this moment)
Subarachnoid haemorrhage (SAH) is a stroke subtype with high mortality and social cost. Up to now, there are few or no specific therapy for the condition, which makes it urgent to identify new therapeutic targets. Astrocytes and endothelial cells are components of the blood-brain barrier (BBB) that have been described as protagonists in the complex pathophysiology of SAH, therefore likely…
The central nervous system (CNS) exhibits a limited regeneration process due to the formation of a glial scar after the occurrence of an injury. The glial scar acts as a barrier against the entrance of neuroblasts inside the injury, making it impossible to repair the neural synapses of that zone. The glial scar is formed by reactive astrocytes and oligodendrocytes that produce inhibitory …
Prokineticin 2 (PROK2) and its PKR2 receptor are expressed in different tissues and, in nervous tissue, they are found in neurons, astrocytes, and microglia. In the central nervous system (CNS), one of the PROK2 physiological functions is the chemotaxis of neuroblasts from the neurogenic niche of the subventricular zone to the olfactory bulb. In a model of traumatic brain injury (TBI) in …
(Only some records are available in English at this moment)
Hypoxia inducible factor (HIF) is a hypoxia responsive transcription factor activated by oxygen (O2) imbalance between tissue demand and supply. In reactive astrocytes HIF-1± upregulation is related to ischemic tolerance, or preconditioning. Preconditioning is an event capable of promoting resistance to a subsequent severe ischemic insult, by decreasing the injury area. The literature dat…
The concept of organ-on-a-chip comprises different models or reproduction of tissues and organs in vitro form the combination of cells, and biocompatible has become an alternative for in vivo studies. The world initiatives to reduce the number of lab animals used in experimental research were the start, although the scientific community soon realized that organs-on-a-chip have broader pot…
3D bioprinting technology has been a promising alternative for tissue engineering, due to its capacity to construct highly organized structures through the well-controlled deposition of cells and biomaterials, forming tissues with similar characteristics to those found in the in vivo model, concerning the geometry, cells density and organization, composition of biomolecules and Extracellu…
(Only some records are available in English at this moment)
Astrocytes are activated by injuries to the central nervous system (CNS) and acquire an undifferentiated state, which is characteristic of neural stem cells (NSCs). In vitro these astrocyte-derived NSC-like cells regain multipotency and long-term self-renew, however, the molecular factors involved in astrocyte dedifferentiation are poorly understood. The purpose of this research project i…
Astrocytes are the first line of cellular response after a brain injury. To fulfil this role, astrocytes undergo a wide variety of alterations in gene expression and phenotype. Increasing evidence indicates that neurogenesis may have a regenerative role in response to brain injury and disease. Moreover, it has been suggested that, activation of signaling mechanisms regulating adult neural…
Brain injuries are potentially disabling, generate a high social cost and no neuroprotective/neuroregenerative strategies are clinically available at the moment. Stem cell therapy seems to be a promising strategy for brain repair. Two main strategies have been proposed: 1) exogenous stem cell transplantation, and 2) subventricular zone (SVZ) derived neural stem cell mobilization. The di…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 19 / 16 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 32 / 24 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 65 / 54 | All research grants and scholarships |
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