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Sociedade Brasileira de Biologia Celular (SBBC) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Marimélia Aparecida Porcionatto in research grants and scholarships supported by FAPESP.
The new coronavirus SARS-CoV-2 emerged in December 2019, in China, and disseminated to several countries, causing an acute respiratory disease called COVID-19 (Coronavirus disease 2019). COVID-19 can evolve to severe respiratory infections resulting in high mortality index for people over 60 years of age or people that chronic diseases, such as diabetes, cardiac, and vascular diseases. CO…
The concept of organ-on-a-chip refers to different types of in vitro modeling or reproduction of tissues and organs by combining cells and biocompatible material. This approach has become an attractive alternative for various studies, such as drug testing. The initial push was the worldwide effort to reduce the number of lab animals used in research, by the application of the 3R's - repla…
The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Pr…
(Only some records are available in English at this moment)
Besides the severe damage to the respiratory system, studies have shown the effects of COVID-19 on the Central Nervous System (CNS) in patients with severe infection. Around 30% of all severe COVID-19 patients show neurological complications. The main neurological symptoms are headaches, seizures and consciousness loss, and necropsies of infected patients showing neural degeneration. The …
Hypoxia inducible factor (HIF) is a hypoxia responsive transcription factor activated by oxygen (O2) imbalance between tissue demand and supply. In reactive astrocytes HIF-1± upregulation is related to ischemic tolerance, or preconditioning. Preconditioning is an event capable of promoting resistance to a subsequent severe ischemic insult, by decreasing the injury area. The literature dat…
The concept of organ-on-a-chip comprises different models or reproduction of tissues and organs in vitro form the combination of cells, and biocompatible has become an alternative for in vivo studies. The world initiatives to reduce the number of lab animals used in experimental research were the start, although the scientific community soon realized that organs-on-a-chip have broader pot…
(Only some records are available in English at this moment)
After the central nervous system is injured, astrocytes go through a process of activation, which involves cellular changes to promote tissue repair, leading to the generation of reactive astrocytes. One of the changes is astrocyte dedifferentiation, which can be described as the transition of mature astrocytes to a less differentiated state, similar to neural-stem cells. This phenomenon …
The Nox3eqlb mouse is a mutant line with phenotype of lack of motor coordination and equilibrium selected by a mutagenesis project by ENU (ethylnitroso-urea). This mouse shows increased proliferation of granule cell progenitors (GCPs) during postnatal development (up to 15 days of age), as well as a disorganized Purkinje cell layer. Recently, our group identified the mutation that causes …
The cerebellum is responsible for controlling different motor and cognitive functions. It is also an important model for studying neurogenesis because it has a simplified cortical architecture and a considerable part of its development unravels after the embryonic stage. Cerebellar neural stem cells (CNSC) that can differentiate into the main cell types of the cerebellum have been isolate…
(Only some records are available in English at this moment)
Astrocytes are activated by injuries to the central nervous system (CNS) and acquire an undifferentiated state, which is characteristic of neural stem cells (NSCs). In vitro these astrocyte-derived NSC-like cells regain multipotency and long-term self-renew, however, the molecular factors involved in astrocyte dedifferentiation are poorly understood. The purpose of this research project i…
Astrocytes are the first line of cellular response after a brain injury. To fulfil this role, astrocytes undergo a wide variety of alterations in gene expression and phenotype. Increasing evidence indicates that neurogenesis may have a regenerative role in response to brain injury and disease. Moreover, it has been suggested that, activation of signaling mechanisms regulating adult neural…
Brain injuries are potentially disabling, generate a high social cost and no neuroprotective/neuroregenerative strategies are clinically available at the moment. Stem cell therapy seems to be a promising strategy for brain repair. Two main strategies have been proposed: 1) exogenous stem cell transplantation, and 2) subventricular zone (SVZ) derived neural stem cell mobilization. The di…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 19 / 16 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 28 / 20 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 61 / 50 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 15 |
| Citations | 99 |
| Cit./Article | 6.6 |
| Data from Web of Science | |
M.A. PORCIONATTO. The extracellular matrix provides directional cues for neuronal migration during cerebellar development. Brazilian Journal of Medical and Biological Research, v. 39, n. 3, p. 313-320, Mar. 2006. (03/13637-5)
DE MELO, BRUNA A. G.; JODAT, YASAMIN A.; CRUZ, ELISA M.; BENINCASA, JULIA C.; SHIN, SU RYON; PORCIONATTO, MARIMELIA A.. Strategies to use fibrinogen as bioink for 3D bioprinting fibrin-based soft and hard tissues. Acta Biomaterialia, v. 117, p. 60-76, NOV 2020. Web of Science Citations: 0. (18/23039-3, 18/12605-8)
MAZZONETTO, P. C.; ARIZA, C. B.; OCANHA, S. G.; DE SOUZ, T. A.; KO, G. M.; MENCK, C. F. M.; MASSIRONI, S. M. G.; PORCIONATTO, M. A.. Mutation in NADPH oxidase 3 (NOX3) impairs SHH signaling and increases cerebellar neural stem/progenitor cell proliferation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1865, n. 6, p. 1502-1515, JUN 1 2019. Web of Science Citations: 0. (18/05635-8, 14/19204-8, 12/25387-2, 17/18765-4)
ZAMPRONI, LAURA N.; TEIXEIRA, DANIELA; ALLIEGRO, AMANDA A.; MAUGERI, IEDA L.; DES RIEUX, ANNE; PORCIONATTO, MARIMELIA A.. Decreased viability and neurite length in neural cells treated with chitosan-dextran sulfate nanocomplexes. NeuroToxicology, v. 76, p. 33-43, JAN 2020. Web of Science Citations: 0. (12/00652-5, 14/23797-4)
GALINDO, LAYLA T.; MUNDIM, MAYARA T. V. V.; PINTO, AGNES S.; CHIARANTIN, GABRIELLY M. D.; ALMEIDA, MAIRA E. S.; LAMERS, MARCELO L.; HORWITZ, ALAN R.; SANTOS, MARINILCE F.; PORCIONATTO, MARIMELIA. Chondroitin Sulfate Impairs Neural Stem Cell Migration Through ROCK Activation. Molecular Neurobiology, v. 55, n. 4, p. 3185-3195, APR 2018. Web of Science Citations: 6. (11/00526-7)
GRANATO, ALESSANDRO E. C.; RIBEIRO, ANDRE C.; MARCIANO, FERNANDA R.; RODRIGUES, BRUNO V. M.; LOBO, ANDERSON O.; PORCIONATTO, MARIMELIA. Polypyrrole increases branching and neurite extension by Neuro2A cells on PBAT ultrathin fibers. Nanomedicine-Nanotechnology Biology and Medicine, v. 14, n. 6, p. 1753-1763, AUG 2018. Web of Science Citations: 1. (12/00652-5, 11/17877-7, 11/20345-7)
MUNDIM, MAYARA VIEIRA; ZAMPRONI, LAURA NICOLETI; SARDINHA PINTO, AGNES ARAUJO; GALINDO, LAYLA TESTA; XAVIER, ANDRE MACHADO; GLEZER, ISAIAS; PORCIONATTO, MARIMELIA. A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury. Molecular and Cellular Neuroscience, v. 94, p. 1-10, JAN 2019. Web of Science Citations: 1. (12/06810-1, 12/00652-5)
ADELITA, TAIS; STILHANO, ROBERTA SESSA; HAN, SANGWON; JUSTO, GISELLE ZENKER; PORCIONATTO, MARIMELIA. Proteolytic processed form of CXCL12 abolishes migration and induces apoptosis in neural stem cells in vitro. STEM CELL RESEARCH, v. 22, p. 61-69, JUL 2017. Web of Science Citations: 5. (12/00652-5, 15/19231-8, 11/11388-4)
GRANATO, ALESSANDRO E. C.; DA CRUZ, EDGAR FERREIRA; RODRIGUES-JUNIOR, DORIVAL MENDES; MOSINI, AMANDA CRISTINA; ULRICH, HENNING; RODRIGUES, BRUNO V. M.; CHEFFER, ARQUIMEDES; PORCIONATTO, MARIMELIA. A novel decellularization method to produce brain scaffolds. TISSUE & CELL, v. 67, DEC 2020. Web of Science Citations: 0. (12/00652-5)
CALIO, MICHELE LONGONI; MOSINI, AMANDA CRISTINA; MARINHO, DARCI SOUZA; SALLES, GEISA NOGUEIRA; MASSINHANI, FERNANDO HENRIQUE; KO, GUI MI; PORCIONATTO, MARIMELIA APARECIDA. Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease. Neurobiology of Disease, v. 148, JAN 2021. Web of Science Citations: 0. (15/19231-8)
CHANG, EUN HYUK; ADORJAN, ISTVAN; MUNDIM, MAYARA V.; SUN, BIN; DIZON, MARIA L. V.; SZELE, FRANCIS G.. Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet. FRONTIERS IN NEUROSCIENCE, v. 10, AUG 2 2016. Web of Science Citations: 24. (12/06810-1, 14/00927-0)
ZAMPRONI, LAURA N.; GRINET, MARCO A. V. M.; MUNDIM, MAYARA T. V. V.; REIS, MARCELLA B. C.; GALINDO, LAYLA T.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.; PORCIONATTO, MARIMELIA. Rotary jet-spun porous microfibers as scaffolds for stem cells delivery to central nervous system injury. Nanomedicine-Nanotechnology Biology and Medicine, v. 15, n. 1, p. 98-107, JAN 2019. Web of Science Citations: 4. (09/05700-5, 11/17877-7, 12/00652-5, 11/20345-7)
GRANATO, ALESSANDRO E. C.; RODRIGUES, BRUNO V. M.; RODRIGUES-JUNIOR, DORIVAL M.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.; PORCIONATTO, MARIMELIA A.. Magnetic super-hydrophilic carbon nanotubes/graphene oxide composite as nanocarriers of mesenchymal stem cells: Insights into the time and dose dependences. Materials Science & Engineering C-Materials for Biological Applications, v. 67, p. 694-701, OCT 1 2016. Web of Science Citations: 4. (11/20345-7, 15/08523-8, 11/17877-7, 12/00652-5)
LUN, MELODY P.; JOHNSON, MATTHEW B.; BROADBELT, KEVIN G.; WATANABE, MOMOKO; KANG, YOUNG-JIN; CHAU, KEVIN F.; SPRINGEL, MARK W.; MALESZ, ALEXANDRA; SOUSA, ANDRE M. M.; PLETIKOS, MIHOVIL; et al. Spatially Heterogeneous Choroid Plexus Transcriptomes Encode Positional Identity and Contribute to Regional CSF Production. JOURNAL OF NEUROSCIENCE, v. 35, n. 12, p. 4903-4916, MAR 25 2015. Web of Science Citations: 29. (13/24501-9)
FILIPPO, THAIS R. M.; GALINDO, LAYLA T.; BARNABE, GABRIELA F.; ARIZA, CAROLINA B.; MELLO, LUIZ E.; JULIANO, MARIA A.; JULIANO, LUIZ; PORCIONATTO, MARIMELIA A.. CXCL12 N-terminal end is sufficient to induce chemotaxis and proliferation of neural stem/progenitor cells. STEM CELL RESEARCH, v. 11, n. 2, p. 913-925, SEP 2013. Web of Science Citations: 24. (05/04061-8, 12/00652-5)
CHIARANTIN, GABRIELLY M. D.; DELGADO-GARCIA, LINA M.; ZAMPRONI, LAURA N.; LIMA, MARCELO A.; NADER, HELENA B.; TERSARIOL, IVARNE L. S.; PORCIONATTO, MARIMELIA. Neuroprotective effect of heparin Trisulfated disaccharide on ischemic stroke. GLYCOCONJUGATE JOURNAL, v. 38, n. 1, JAN 2021. Web of Science Citations: 0. (11/00526-7, 15/03964-6, 17/18765-4)
(References retrieved automatically from State of São Paulo Research Institutions)
GOUVÊA, Andréia Eduarte Escudero. Estudo da expressäo do proteoglicano de heparam sulfato (Sindecam-4) por células endoteliais bloqueadas em G1 por PMA. 132 f. Dissertação (Mestrado) - Escola Paulista de Medicina. Universidade Federal de São Paulo (UNIFESP). São Paulo. (00/01428-4)