graduate at Ciências Biológicas from Universidade de São Paulo (1996), master's at Química Bioquímica from Universidade de São Paulo (1999) and ph.d. at Morphology from Universidade de São Paulo (2003). Has experience in Biochemistry, acting on the following subjects: papilomavírus, variantes moleculares, câncer cervical, neoplasia cervical and prevalência. (Source: Lattes Curriculum)
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Persistent infections by high-risk HPVs (Human Papillomavirus) are associated with the development of Cervical and Vulvar Cancer in women, Penile Cancer in men, and anal and Oropharyngeal Tumors in both gender. Among this group, HPV-16 is worldwide the most prevalent type in Cervical Carcinomas, followed by HPV-18. In neoplasias of other anogenital sites and the oropharynx, HPV-16 is dete…
HPV-16 and HPV-18 are strongly associated with risk of developing cervical cancer. Worldwide, HPV-16 type is the most prevalent type in invasive squamous cell carcinomas of the cervix, followed by HPV-18, whereas HPV-18 is the most prevalent type in adenocarcinoma specimens. HPV-18 intratypic nucleotide variability has been studied resulting in important findings concerning the evolution …
HPV is primarily transmitted by sexual contact and infection by these viruses is strongly associated with the development of tumors in the cervix, vulva and anus in women, cancer of the penis and anus in men, as well as tumors in the head and neck in both genders. Case-control studies conducted in women with cervical cancer showed that male partners' sexual behavior influences the risk of…
(Only some records are available in English at this moment)
The development of tumors associated with HPV (Human Papillomavirus) is mainly due to persistent infections by oncogenic high-risk HPVs, and among them HPV-16 is the most prevalent worldwide in both pre-neoplastic lesions and cancers in different anatomical sites of men and women. High-risk HPV oncoproteins E6 and E7 associate and inactivate tumor suppressor proteins p53 and pRb respectiv…
The E6 and E7 genes encode the HPV oncoproteins that play a central role in the viral life cycle and malignant transformation. The expression of these oncoproteins depends especially on the activation of the viral promoter contained in the Long Control Region (LCR). In addition, this region contains regulatory elements where cellular Transcription Factors (TFs) bind. The repertoire of TFs…
(Only some records are available in English at this moment)
Persistent infections by high-risk HPVs (human papillomavirus) are associated with the development of cervical and vulvar cancer in women, penile cancer in men, and anal and oropharyngeal tumors in both gender. Among this group, HPV-16 is worldwide the most prevalent type in cervical carcinomas, followed by HPV-18. In neoplasias of other anogenital sites and the oropharynx, HPV-16 is dete…
Human papillomavirus (HPV) type most worldwide prevalent in pre-invasive tumors and in invasive carcinomas of the cervix is the HPV-16 , followed by HPV-18. However, HPV-18 predominates in adenocarcinomas (56%) and adenosquamous tumors (39% ). Several evidences indicate that synchronization of the virus life cycle by epithelial differentiation program, in addition to epitheliotropism, is …
(Only some records are available in English at this moment)
Cutaneous human papillomavirus (HPV) types from the beta genus are ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of beta-HPVs and the development of cutaneous squamous cell carcinomas (cSCC) were initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis (EV). About half of EV patients harbor m…
HPV-16 and HPV-18 are strongly associated with the risk of developing cervical cancer. Worldwide, HPV-16 is the most prevalent type in invasive squamous cell carcinomas of the cervix, followed by HPV-18, whereas HPV-18 is the most prevalent type in adenocarcinoma specimens. HPV-18 intratypic nucleotide variability has been studied resulting in important findings concerning the evolution a…
HPV is primarily transmitted by sexual contact and infection by these viruses is strongly associated with the development of tumors in the cervix, vulva and anus in women, cancer of the penis and anus in men, as well as tumors in the head and neck in both genders. Case-control studies conducted in women with cervical cancer showed that male partners' sexual behavior influences the risk of…
| 1 / 1 | Ongoing research grants |
| 7 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 12 / 8 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 27 / 22 | All research grants and scholarships |
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CV Lattes
ORCID