CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Serviços de Saúde (CSS). Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP) (Institutional affiliation from the last research proposal) Birthplace: Uruguai
holds a degree in Biological Sciences from the University of São Paulo (1996), a master and PhD degrees in Molecular Biology and Biochemistry from the Department of Biochemistry of the Institute of Chemistry of the University of São Paulo (2003), and the title of Professor from the Faculty of Medicine, University of São Paulo (2015). She is currently a Research Coordinator at the Center for Translational Research in Oncology at the Cancer Institute of the State of São Paulo, ICESP, and Collaborating Professor at the Faculty of Medicine at USP. She has experience in the area of #8203;#8203;Biochemistry, with an emphasis on Molecular Biology, working mainly on the following topics: papillomavirus, molecular variants, cancer, cellular transformation, cellular immortalization and viral transcription. Master's and PhD supervisor at the Faculty of Medicine of USP - Discipline of Oncology. (Source: Lattes Curriculum)
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Persistent infections by high-risk HPVs (human papillomavirus) are associated with the development of cervical, vaginal and vulvar cancer in women, penile cancer in men, in addition to anal canal and oropharyngeal tumors in both genders. Among this group, HPV-16 is worldwide the most prevalent type in cervical carcinomas, followed by HPV-18. In neoplasia of other anogenital sites and the …
Persistent infections by high-risk HPVs (Human Papillomavirus) are associated with the development of Cervical and Vulvar Cancer in women, Penile Cancer in men, and anal and Oropharyngeal Tumors in both gender. Among this group, HPV-16 is worldwide the most prevalent type in Cervical Carcinomas, followed by HPV-18. In neoplasias of other anogenital sites and the oropharynx, HPV-16 is dete…
(Only some records are available in English at this moment)
The development of tumors associated with HPV (Human Papillomavirus) is mainly due to persistent infections by oncogenic high-risk HPVs, and among them HPV-16 is the most prevalent worldwide in both pre-neoplastic lesions and cancers in different anatomical sites of men and women. High-risk HPV oncoproteins E6 and E7 associate and inactivate tumor suppressor proteins p53 and pRb respectiv…
The E6 and E7 genes encode the HPV oncoproteins that play a central role in the viral life cycle and malignant transformation. The expression of these oncoproteins depends especially on the activation of the viral promoter contained in the Long Control Region (LCR). In addition, this region contains regulatory elements where cellular Transcription Factors (TFs) bind. The repertoire of TFs…
(Only some records are available in English at this moment)
The life cycle of human papillomaviruses is deeply correlated with the differentiation process of the squamous epithelium, with the transcriptional activity and production of the oncoproteins E6 and E7 being regulated by cellular transcription factors. Our current data shows that the transcription factor GATA3 is a negative regulator of HPV transcription and may have a role in the tumorig…
Cutaneous human papillomavirus (HPV) types from the beta genus are ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of beta-HPVs and the development of cutaneous squamous cell carcinomas (cSCC) were initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis (EV). About half of EV patients harbor m…
HPV-16 and HPV-18 are strongly associated with the risk of developing cervical cancer. Worldwide, HPV-16 is the most prevalent type in invasive squamous cell carcinomas of the cervix, followed by HPV-18, whereas HPV-18 is the most prevalent type in adenocarcinoma specimens. HPV-18 intratypic nucleotide variability has been studied resulting in important findings concerning the evolution a…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 9 / 8 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 15 / 11 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 31 / 26 | All research grants and scholarships |
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