CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
I am currently working at the Department of Microbiology on the Institute of Biomedical Science (ICB) of the University of São Paulo (since 07/2014). I have Ph.D. on Molecular Biophysics by the State University of São Paulo (2007) and Post-Doctoral training by University of Cambridge on Tom Blundell supervision (2007-2011) and I was Young Research Fellow at LNBio (Campinas-SP) (2012-2014). I am a Biologist by the State University of São Paulo. I have experience in biochemistry, focused on protein biochemistry (structural biology), structure-based drug discovery, protein targets of Mycobacterium tuberculosis and natural products biosynthesis. (Source: Lattes Curriculum)
The mycobacterium cell wall is a complex and highly regulated structure and proteins involved in its biosynthesis or remodelling can drive the balance between the cell elongation and the cell division. The enzymes involved in the assembly of this complex structure, which is constituted by peptidoglycan, arabinogalactan and mycolic acids, as well the enzymes responsible for its regulation …
Soil microorganisms are responsible for the production of a large number of antibiotics due to the highly competitive environment for space and nutrients. In addition, we can also use such molecules in the treatment of various illness, including infectious diseases and cancer. Several groups of antibiotics, such as aminoglycosides, changed completely the Medicine because to the benefits o…
Nature has the extraordinary capacity of producing structurally exquisite molecules that possess useful bioactivities for human and animal health. A field of high interest and intense active includes the mechanisms of natural products ring formation because the peculiarity of the involved enzymes. Tetronasin and tetronomycin are tetronate containing natural products, which have similar st…
Natural products are an important source of molecules that are used by humans to treat various diseases, such as cancer and infectious diseases. These molecules generally are derivatives of secondary metabolism of microorganisms and plants through of sophisticated biosynthetic systems. However, the mechanism of how those enzymes, which are in gene clusters, act to produce specific compoun…
(Only some records are available in English at this moment)
Tuberculosis is one of the 10 leading causes of death worldwide and is caused by the agent Mycobacterium tuberculosis. The increasingly recurring emergence of resistant strains of this pathogen motivates researchers around the world and leads to the need for developing new drugs to combat it M. tuberculosis, requiring constant validation of new effective drugs. In this sense, PanK (CoaA) …
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis that affects about around 10 million people per year worldwide, being a leading cause of death from infectious disease. The therapy used to treat tuberculosis is complex and requires at least 3 different relatively toxic drugs for a period of approximately 6 months, which facilitates patient withdrawal and the emer…
Although the infection caused by Mycobacterium tuberculosis is considered one of the oldest and largely studied disease of humankind, it follows as a leader in both incidence and mortality rates, among bacterial infections. According to the World Health Organization, about 9.6 million of new cases of tuberculosis and 1.5 million of deaths were notified only in 2014. In addition, it is est…
Tuberculosis (TB), infectious disease caused by the microorganism Mycobacterium tuberculosis, is the major cause of death by a single infectious agent in the world. The dependence of an extensive administration scheme for the effectiveness of the chemotherapy currently used makes adhesion difficult, leading to the emergence of multidrug-resistant strains. This creates a need for research …
Staphylococcus aureus infections are a serious problem of public health because of the resistance of this bacteria to most of the in-use antibiotics. Although this microorganism is part of the microbiota, it eventually could cause infections, including cutaneous infections or even cause the death of hospitalized patients due to nosocomial infections. Because of these problems, the researc…
(Only some records are available in English at this moment)
Organohalogen natural products represent an important role in the research of natural products. Various experiments have shown that natural compounds may have their biologic activity altered by presence of absence of halogen. Glycopeptide antibiotics, such as vancomycin and teicoplanin are halogenated natural products and they have substantial medical importance. They are clinically used …
| 1 / 1 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 18 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 28 / 21 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 15 |
| Citations | 42 |
| Cit./Article | 2.8 |
| Data from Web of Science | |
KRONENBERGER, THALES; FERREIRA, GLAUCIO MONTEIRO; FERREIRA DE SOUZA, ALFREDO DANILO; SANTOS, SORAYA DA SILVA; POSO, ANTTI; RIBEIRO, JOAO AUGUSTO; TAVARES, MAURICIO TEMOTHEO; PAVAN, FERNANDO ROGERIO; GOULART TROSSINI, GUSTAVO HENRIQUE; BERTACINE DIAS, MARCIO VINICIUS; et al. Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors. Bioorganic & Medicinal Chemistry, v. 28, n. 15, AUG 1 2020. Web of Science Citations: 0. (13/18160-4, 17/00689-0, 13/15906-5, 17/25543-8)
LUHAVAYA, HANNA; DIAS, MARCIO V. B.; WILLIAMS, SIMON R.; HONG, HUI; DE OLIVEIRA, LUCIANA G.; LEADLAY, PETER F.. Enzymology of Pyran RingA Formation in Salinomycin Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 54, n. 46, p. 13622-13625, NOV 9 2015. Web of Science Citations: 18. (11/17510-6, 10/15971-3)
ADRIANI, PATRICIA P.; DE PAIVA, FERNANDA C. R.; DE OLIVEIRA, GABRIEL S.; LEITE, AMANDA C.; SANCHES, ADRIANA S.; LOPES, ADRIANA RIOS; DIAS, MARCIO V. B.; CHAMBERGO, FELIPE S.. Structural and functional characterization of the glutathione peroxidase-like thioredoxin peroxidase from the fungus Trichoderma reesei. International Journal of Biological Macromolecules, v. 167, p. 93-100, JAN 15 2021. Web of Science Citations: 0. (18/00351-1, 17/25705-8, 19/05227-0, 14/24107-1)
BERTACINE DIAS, MARCIO V.; SANTOS, JADEMILSON C.; LIBREROS-ZUNIGA, GERARDO A.; RIBEIRO, JOAO A.; CHAVEZ-PACHECO, SAIR M.. Folate biosynthesis pathway: mechanisms and insights into drug design for infectious diseases. Future Medicinal Chemistry, v. 10, n. 8, p. 935-959, APR 2018. Web of Science Citations: 5. (13/15906-5, 15/09188-8, 10/15971-3)
DE OLIVEIRA, GABRIEL S.; ADRIANI, PATRICIA P.; RIBEIRO, JOAO AUGUSTO; MORISSEAU, CHRISTOPHE; HAMMOCK, BRUCE D.; DIAS, MARCIO VINICIUS B.; CHAMBERGO, FELIPE S.. The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. International Journal of Biological Macromolecules, v. 129, p. 653-658, MAY 15 2019. Web of Science Citations: 0. (13/15906-5, 16/12859-4, 15/03329-9, 15/09188-8, 18/00351-1, 14/24107-1, 17/25705-8)
BERTACINE DIAS, MARCIO VINICIUS; TYRAKIS, PETROS; DOMINGUES, ROMENIA RAMOS; PAES LEME, ADRIANA FRANCO; BLUNDELL, TOM L.. Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, v. 22, n. 1, p. 94-103, JAN 7 2014. Web of Science Citations: 13. (10/15971-3)
BURY, PRISCILA DOS SANTOS; HUANG, FANGLU; LI, SICONG; SUN, YUHUI; LEADLAY, PETER F.; BERTACINE DIAS, MARCIO VINICIUS. Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis. ACS Chemical Biology, v. 12, n. 11, p. 2779-2787, NOV 2017. Web of Science Citations: 2. (14/07843-6, 10/15971-3, 14/50324-0, 15/09188-8)
LITTLE, RORY; PAIVA, FERNANDA C. R.; JENKINS, ROBERT; HONG, HUI; SUN, YUHUI; DEMYDCHUK, YULIYA; SAMBORSKYY, MARKIYAN; TOSIN, MANUELA; LEEPER, FINIAN J.; DIAS, MARCIO V. B.; et al. Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis. NATURE CATALYSIS, v. 2, n. 11, p. 1045-1054, NOV 2019. Web of Science Citations: 0. (15/09188-8, 17/50140-4, 18/00351-1)
RIBEIRO, JOAO A.; HAMMER, ALEXANDER; LIBREROS-ZUNIGA, GERARDO A.; CHAVEZ-PACHECO, SAIR M.; TYRAKIS, PETROS; DE OLIVEIRA, GABRIEL S.; KIRKMAN, TIMOTHY; EL BAKALI, JAMAL; ROCCO, SILVANA A.; SFORCA, MAURICIO L.; et al. Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES, v. 6, n. 8, p. 2192-2201, AUG 14 2020. Web of Science Citations: 0. (10/15971-3, 13/15906-5, 18/00351-1)
RIBEIRO, JOAO AUGUSTO; CHAVEZ-PACHECO, SAIR MAXIMO; DE OLIVEIRA, GABRIEL STEPHANI; SILVA, CATHARINA DOS SANTOS; PIMENTA GIUDICE, JOAO HENRIQUE; LIBREROS-ZUNIGA, GERARDO ANDRES; BERTACINE DIAS, MARCIO VINICIUS. Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 75, n. 7, p. 682-693, JUL 2019. Web of Science Citations: 0. (13/15906-5, 15/09188-8, 18/00351-1, 14/24486-2, 16/18721-4)
DE ARAUJO, NATALIA CERRONE; BURY, PRISCILA DOS SANTOS; TAVARES, MAURICIO TEMOTHEO; HUANG, FANGLU; PARISE-FILHO, ROBERTO; LEADLAY, PETER; BERTACINE DIAS, MARCIO VINICIUS. Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in the Biosynthesis of Gentamicin. ACS Chemical Biology, v. 14, n. 5, p. 925-933, MAY 2019. Web of Science Citations: 0. (10/15971-3, 15/09188-8, 14/07843-6, 14/50324-0)
WILSON, CAROLINA; DE OLIVEIRA, GABRIEL S.; ADRIANI, PATRICIA P.; CHAMBERGO, FELIPE S.; DIAS, MARCIO V. B.. Structure of a soluble epoxide hydrolase identified in Trichoderma reesei. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1865, n. 8, p. 1039-1045, AUG 2017. Web of Science Citations: 3. (15/03329-9, 10/15971-3, 15/09188-8, 14/24107-1)
DE PAIVA, FERNANDA C. R.; CHAN, KAREN; SAMBORSKYY, MARKIYAN; SILBER, ARIEL M.; LEADLAY, PETER F.; DIAS, MARCIO V. B.. The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 76, n. 12, p. 1201-1210, DEC 1 2020. Web of Science Citations: 0. (16/06034-2, 18/00351-1)
CARDOSO, TABATA P.; DE SA, LARISSA A.; BURY, PRISCILA DOS S.; CHAVEZ-PACHECO, SAIR M.; DIAS, MARCIO V. B.. Cloning, expression, purification and biophysical analysis of two putative halogenases from the glycopeptide A47,934 gene cluster of Streptomyces toyocaensis. Protein Expression and Purification, v. 132, p. 9-18, APR 2017. Web of Science Citations: 0. (10/15971-3, 12/23427-7, 12/16631-7)
LIBREROS-ZUNIGA, GERARDO ANDRES; SILVA, CATHARINA DOS SANTOS; FERREIRA, RAFAELA SALGADO; BERTACINE DIAS, MARCIO VINICIUS. Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics by L,D-Transpeptidase 3 (Ldt(Mt3)) from Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES, v. 5, n. 2, p. 260-271, FEB 2019. Web of Science Citations: 1. (10/15971-3, 16/18721-4, 15/09188-8)
DIAS‚ B.; MARCIO‚ V.; ELY‚ F.; PALMA‚ M.S.; DE AZEVEDO‚ W.F.; BASSO‚ L.A.; SANTOS‚ D.S.. Chorismate synthase: an attractive target for drug development against orphan diseases. CURRENT DRUG TARGETS, v. 8, n. 3, p. 437-444, 2007. (01/07532-0)
RIBEIRO MARQUES‚ M.; HENRIQUE PEREIRA‚ J.; OLIVEIRA‚ J.S.; AUGUSTO BASSO‚ L.; FILGUEIRA DE AZEVEDO‚ W.; SANTIAGO SANTOS‚ D.; SERGIO PALMA‚ M.. The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials. CURRENT DRUG TARGETS, v. 8, n. 3, p. 445-457, 2007. (01/07532-0)
(References retrieved automatically from State of São Paulo Research Institutions)
DIAS, Marcio Vinicius Bertacine. Estudo estrutural de proteínas alvo de Mycobacterium tuberculosis. 125 f. Tese (Doutorado) - Instituto de Biociências, Letras e Ciências Exatas. Universidade Estadual Paulista. São José do Rio Preto. (03/12472-2)
GIUDICE, João Henrique Pimenta. Estudo estrutural e biofísico de três enzimas da via do folato de microrganismos patogênicos.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (14/24486-2)