CV Lattes
ORCID
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
I am currently working at the Department of Microbiology on the Institute of Biomedical Science (ICB) of the University of São Paulo (since 07/2014). I have Ph.D. on Molecular Biophysics by the State University of São Paulo (2007) and Post-Doctoral training by University of Cambridge on Tom Blundell supervision (2007-2011) and I was Young Research Fellow at LNBio (Campinas-SP) (2012-2014). I am a Biologist by the State University of São Paulo. I have experience in biochemistry, focused on protein biochemistry (structural biology), structure-based drug discovery, protein targets of Mycobacterium tuberculosis and natural products biosynthesis. (Source: Lattes Curriculum)
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Infectious diseases are one of the major problems of the current public and worldwide health. Although much has been released about infectious caused by bacteria, those infectious diseases caused by invasive fungi are also alarming and lead to the death of a high number of patients, particularly those from hospital environments or those suffering from immunodeficiency. Furthermore, there …
Tuberculosis is an infectious disease caused predominantly by Mycobacterium tuberculosis and leads to the death of more than a million people every year worldwide. The treatment of tuberculosis consists of the use of four different antimicrobials for at least six months. Although antimicrobial resistance mechanisms in tuberculosis do not involve horizontal transfer, mutations in responsib…
The main function of the bacterial cell wall is to maintain the shape and integrity of the cell. However, far from being a static structure, the cell wall undergoes constant remodeling and modifications throughout the cell cycle. The peptidoglycan layer is one of the main components of the bacterial cell wall. Therefore, the balance between peptidoglycan synthesis and degradation during c…
(Only some records are available in English at this moment)
Tuberculosis is one of the major infectious diseases that afflict humankind, which causes the death of about a million people worldwide. Because of the intensive use of antimicrobials in the treatment of this disease, resistance is an extremely worrisome feature and that significantly worsens its therapeutic interventions. Bacterial resistance to the main in-use antimicrobials, particular…
The mycobacterium cell wall is a complex and highly regulated structure and proteins involved in its biosynthesis or remodelling can drive the balance between the cell elongation and the cell division. The enzymes involved in the assembly of this complex structure, which is constituted by peptidoglycan, arabinogalactan and mycolic acids, as well the enzymes responsible for its regulation …
Soil microorganisms are responsible for the production of a large number of antibiotics due to the highly competitive environment for space and nutrients. In addition, we can also use such molecules in the treatment of various illness, including infectious diseases and cancer. Several groups of antibiotics, such as aminoglycosides, changed completely the Medicine because to the benefits o…
(Only some records are available in English at this moment)
Aminoglycosides, one of the groups of bioactive molecules isolated from actinobacteria, are antibiotics rich in amino and hydroxyl groups. The mechanism of action of these molecules consists of the interaction of the amino groups contained in their amino sugars with the ribosomal RNA of bacteria. The binding occurs specifically at the A binding site of the 30S portion of the bacterial rib…
Integrative Conjugative Elements (ICEs) are crucial mobile genetic elements for horizontal gene transfer (HGT). Incorporated into genomic DNA and replicated alongside the bacterial chromosome, ICEs differ from other genomic islands due to their ability to excise and integrate into recipient bacterial genomes through conjugation. These elements are widely distributed among bacterial specie…
Bacterial resistance to antibiotics is one of the greatest public health challenges today, characterized as a growing threat that deteriorates the efficacy of these drugs. Natural products from microorganisms have shown promise in the search for new active molecules that contain mechanisms capable of circumventing this resistance. Among natural products, polyketides represent a broad clas…
(Only some records are available in English at this moment)
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that affects, approximately, 10 million people a year, and is one of the main causes of death by infections. The treatment of tuberculosis requires the use of at least three drugs that are relatively toxic to patients. As the ideal treatment regimen is approximately six months, individuals are likely to discon…
Tuberculosis is a serious problem of public health because of the number of deaths caused by the disease and also by the number of resistant and multiresistant strains to all in use drugs. Among the key medicines used in the treatment of tuberculosis, isoniazid (INH) and pyrazinamide (PZA) are the first-line drugs, together withethambutol (EMB) and rifampicin (RIF). Recently, it has been …
Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (MTB), one of the major causes of death in the world. The treatment of the disease involves the association of several drugs for long periods, which results in the interruption of the treatment and contributes to the emergence of multidrug-resistant strains. Consequently, the discovery of new drug…
(Only some records are available in English at this moment)
The discovery of new specialized metabolites is vital in addressing the challenge posed by emerging superbugs and drug resistance. Soil and freshwater environments have fostered the evolution of microorganisms with unique adaptations, leading to the production of bioactive compounds with significant pharmacological potential. The genus Streptomyces has a rich history in antibiotic discove…
The development of new molecules aiming at treating infections caused by resistant pathogens is a challenging path. Strategies to improve existing compounds or discover new ones require a lot of effort and, especially, time. There are difficulties in not only isolating a new compound but also finding interesting chemical modifications that could achieve efficiency in vivo. In this scenari…
Among the main drugs used to treat tuberculosis, isoniazid (INH) is considered a first-line drug and fluoroquinolones (FQL), mainly Moxifloxacin (MFX), are gaining space in the most current treatment regimens. Particularly, for INH and MFX, their targets, which include the enzymes InhA encoded by inhA gene, and DNA gyrase, encoded by gyrA and GryB genes, respectively, have the characteris…
As highlighted by recent global health reports, millions of deaths annually occur from bacterial infections. Although there is a broad availability of antimicrobial agents, the growing resistance of bacteria to these treatments is becoming an increasingly public health problem. Therefore, the development of new antimicrobial agents is critical. Type II topoisomerases have proven to be eff…
Natural products represent an important source of bioactive materials for medical and veterinary use. Although the field of biological chemistry has had considerable advances in knowledge of these compounds, there is still a lack of understanding of the underlying mechanisms of their biogenesis. An important class of natural products includes polyketides, which are molecules that have dis…
Organohalogen natural products represent an important role in the research of natural products. Various experiments have shown that natural compounds may have their biologic activity altered by presence of absence of halogen. Glycopeptide antibiotics, such as vancomycin and teicoplanin are halogenated natural products and they have substantial medical importance. They are clinically used …
| 5 / 5 | Ongoing grants |
| 7 / 7 | Completed research grants |
| 12 / 12 | Ongoing scholarships in Brazil |
| 24 / 17 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 54 / 47 | All research grants and scholarships |
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