CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
I am currently working at the Department of Microbiology on the Institute of Biomedical Science (ICB) of the University of São Paulo (since 07/2014). I have Ph.D. on Molecular Biophysics by the State University of São Paulo (2007) and Post-Doctoral training by University of Cambridge on Tom Blundell supervision (2007-2011) and I was Young Research Fellow at LNBio (Campinas-SP) (2012-2014). I am a Biologist by the State University of São Paulo. I have experience in biochemistry, focused on protein biochemistry (structural biology), structure-based drug discovery, protein targets of Mycobacterium tuberculosis and natural products biosynthesis. (Source: Lattes Curriculum)
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The mycobacterium cell wall is a complex and highly regulated structure and proteins involved in its biosynthesis or remodelling can drive the balance between the cell elongation and the cell division. The enzymes involved in the assembly of this complex structure, which is constituted by peptidoglycan, arabinogalactan and mycolic acids, as well the enzymes responsible for its regulation …
Soil microorganisms are responsible for the production of a large number of antibiotics due to the highly competitive environment for space and nutrients. In addition, we can also use such molecules in the treatment of various illness, including infectious diseases and cancer. Several groups of antibiotics, such as aminoglycosides, changed completely the Medicine because to the benefits o…
Nature has the extraordinary capacity of producing structurally exquisite molecules that possess useful bioactivities for human and animal health. A field of high interest and intense active includes the mechanisms of natural products ring formation because the peculiarity of the involved enzymes. Tetronasin and tetronomycin are tetronate containing natural products, which have similar st…
Natural products are an important source of molecules that are used by humans to treat various diseases, such as cancer and infectious diseases. These molecules generally are derivatives of secondary metabolism of microorganisms and plants through of sophisticated biosynthetic systems. However, the mechanism of how those enzymes, which are in gene clusters, act to produce specific compoun…
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Natural products represent an important source of bioactive products that human uses for the treatment of various diseases. Although the field of biological chemistry has had considerable advances in the knowledge of how nature produces many of these compounds, there is still a lack of understanding of these events. However, this field of research is becoming extremely competitive, due to…
The discovery of new secondary metabolites is a challenge for biotechnologists due to the emergence of superbugs and drug resistance. Therefore, Streptomyces sp. have been widely studied by the pharmaceutical industry in the development of compounds with biological activity, such as antibiotics, antitumor and antiviral drugs. Among the metabolites biosynthesized by Streptomyces sp., there…
Leprosy is a chronic infectious disease, caused by Mycobacterium leprae or Hansen´s bacillus, which promotes severe injury to the skin and peripheric nerves and that could lead to physical disability. Brazil figures out as the second country in the number of cases for this disease, which is also strongly associated with low human development indices. Although leprosy has treatment, it req…
(Only some records are available in English at this moment)
Tuberculosis (TB), infectious disease caused by the microorganism Mycobacterium tuberculosis, is the major cause of death by a single infectious agent in the world. The dependence of an extensive administration scheme for the effectiveness of the chemotherapy currently used makes adhesion difficult, leading to the emergence of multidrug-resistant strains. This creates a need for research …
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis that affects about around 10 million people per year worldwide, being a leading cause of death from infectious disease. The therapy used to treat tuberculosis is complex and requires at least 3 different relatively toxic drugs for a period of approximately 6 months, which facilitates patient withdrawal and the emer…
(Only some records are available in English at this moment)
Organohalogen natural products represent an important role in the research of natural products. Various experiments have shown that natural compounds may have their biologic activity altered by presence of absence of halogen. Glycopeptide antibiotics, such as vancomycin and teicoplanin are halogenated natural products and they have substantial medical importance. They are clinically used …
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| 5 / 5 | Ongoing scholarships in Brazil |
| 19 / 12 | Completed scholarships in Brazil |
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| 31 / 24 | All research grants and scholarships |
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