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Marcio Vinicius Bertacine Dias

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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

I am currently working at the Department of Microbiology on the Institute of Biomedical Science (ICB) of the University of São Paulo (since 07/2014). I have Ph.D. on Molecular Biophysics by the State University of São Paulo (2007) and Post-Doctoral training by University of Cambridge on Tom Blundell supervision (2007-2011) and I was Young Research Fellow at LNBio (Campinas-SP) (2012-2014). I am a Biologist by the State University of São Paulo. I have experience in biochemistry, focused on protein biochemistry (structural biology), structure-based drug discovery, protein targets of Mycobacterium tuberculosis and natural products biosynthesis. (Source: Lattes Curriculum)

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FAPESP support in numbers * Updated November 09, 2019
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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications10
Citations43
Cit./Article4.3
Data from Web of Science

BERTACINE DIAS, MARCIO VINICIUS; TYRAKIS, PETROS; DOMINGUES, ROMENIA RAMOS; PAES LEME, ADRIANA FRANCO; BLUNDELL, TOM L.. Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, v. 22, n. 1, p. 94-103, . Web of Science Citations: 14. (10/15971-3)

DIAS‚ B.; MARCIO‚ V.; ELY‚ F.; PALMA‚ M.S.; DE AZEVEDO‚ W.F.; BASSO‚ L.A.; SANTOS‚ D.S.. Chorismate synthase: an attractive target for drug development against orphan diseases. CURRENT DRUG TARGETS, v. 8, n. 3, p. 437-444, . (01/07532-0)

RIBEIRO MARQUES‚ M.; HENRIQUE PEREIRA‚ J.; OLIVEIRA‚ J.S.; AUGUSTO BASSO‚ L.; FILGUEIRA DE AZEVEDO‚ W.; SANTIAGO SANTOS‚ D.; SERGIO PALMA‚ M.. The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials. CURRENT DRUG TARGETS, v. 8, n. 3, p. 445-457, . (01/07532-0)

LIBREROS-ZUNIGA, GERARDO ANDRES; SILVA, CATHARINA DOS SANTOS; FERREIRA, RAFAELA SALGADO; BERTACINE DIAS, MARCIO VINICIUS. Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics by L,D-Transpeptidase 3 (Ldt(Mt3)) from Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES, v. 5, n. 2, p. 260-271, . Web of Science Citations: 0. (16/18721-4, 10/15971-3, 15/09188-8)

RIBEIRO, JOAO AUGUSTO; CHAVEZ-PACHECO, SAIR MAXIMO; DE OLIVEIRA, GABRIEL STEPHANI; SILVA, CATHARINA DOS SANTOS; PIMENTA GIUDICE, JOAO HENRIQUE; LIBREROS-ZUNIGA, GERARDO ANDRES; BERTACINE DIAS, MARCIO VINICIUS. Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 75, n. 7, p. 682-693, . Web of Science Citations: 0. (13/15906-5, 15/09188-8, 18/00351-1, 14/24486-2, 16/18721-4)

WILSON, CAROLINA; DE OLIVEIRA, GABRIEL S.; ADRIANI, PATRICIA P.; CHAMBERGO, FELIPE S.; DIAS, MARCIO V. B.. Structure of a soluble epoxide hydrolase identified in Trichoderma reesei. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1865, n. 8, p. 1039-1045, . Web of Science Citations: 3. (15/03329-9, 10/15971-3, 15/09188-8, 14/24107-1)

BERTACINE DIAS, MARCIO V.; SANTOS, JADEMILSON C.; LIBREROS-ZUNIGA, GERARDO A.; RIBEIRO, JOAO A.; CHAVEZ-PACHECO, SAIR M.. Folate biosynthesis pathway: mechanisms and insights into drug design for infectious diseases. Future Medicinal Chemistry, v. 10, n. 8, p. 935-959, . Web of Science Citations: 5. (10/15971-3, 15/09188-8, 13/15906-5)

CARDOSO, TABATA P.; DE SA, LARISSA A.; BURY, PRISCILA DOS S.; CHAVEZ-PACHECO, SAIR M.; DIAS, MARCIO V. B.. Cloning, expression, purification and biophysical analysis of two putative halogenases from the glycopeptide A47,934 gene cluster of Streptomyces toyocaensis. Protein Expression and Purification, v. 132, p. 9-18, . Web of Science Citations: 0. (10/15971-3, 12/23427-7, 12/16631-7)

BURY, PRISCILA DOS SANTOS; HUANG, FANGLU; LI, SICONG; SUN, YUHUI; LEADLAY, PETER F.; BERTACINE DIAS, MARCIO VINICIUS. Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis. ACS Chemical Biology, v. 12, n. 11, p. 2779-2787, . Web of Science Citations: 2. (10/15971-3, 15/09188-8, 14/07843-6, 14/50324-0)

DE OLIVEIRA, GABRIEL S.; ADRIANI, PATRICIA P.; RIBEIRO, JOAO AUGUSTO; MORISSEAU, CHRISTOPHE; HAMMOCK, BRUCE D.; DIAS, MARCIO VINICIUS B.; CHAMBERGO, FELIPE S.. The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. International Journal of Biological Macromolecules, v. 129, p. 653-658, . Web of Science Citations: 0. (13/15906-5, 16/12859-4, 15/03329-9, 15/09188-8, 18/00351-1, 14/24107-1, 17/25705-8)

DE ARAUJO, NATALIA CERRONE; BURY, PRISCILA DOS SANTOS; TAVARES, MAURICIO TEMOTHEO; HUANG, FANGLU; PARISE-FILHO, ROBERTO; LEADLAY, PETER; BERTACINE DIAS, MARCIO VINICIUS. Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in the Biosynthesis of Gentamicin. ACS Chemical Biology, v. 14, n. 5, p. 925-933, . Web of Science Citations: 0. (10/15971-3, 15/09188-8, 14/07843-6, 14/50324-0)

LUHAVAYA, HANNA; DIAS, MARCIO V. B.; WILLIAMS, SIMON R.; HONG, HUI; DE OLIVEIRA, LUCIANA G.; LEADLAY, PETER F.. Enzymology of Pyran RingA Formation in Salinomycin Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 54, n. 46, p. 13622-13625, . Web of Science Citations: 19. (10/15971-3, 11/17510-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DIAS, Marcio Vinicius Bertacine. Estudo estrutural de proteínas alvo de Mycobacterium tuberculosis. 2007. 125f. Tese (Doutorado) – Instituto de Biociências, Letras e Ciências Exatas. Universidade Estadual Paulista. São José do Rio Preto. (03/12472-2)

GIUDICE, João Henrique Pimenta. Estudo estrutural e biofísico de três enzimas da via do folato de microrganismos patogênicos.. 2018. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (14/24486-2)

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