Marcio Vinicius Bertacine Dias
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
I am currently working at the Department of Microbiology on the Institute of Biomedical Science (ICB) of the University of São Paulo (since 07/2014). I have Ph.D. on Molecular Biophysics by the State University of São Paulo (2007) and Post-Doctoral training by University of Cambridge on Tom Blundell supervision (2007-2011) and I was Young Research Fellow at LNBio (Campinas-SP) (2012-2014). I am a Biologist by the State University of São Paulo. I have experience in biochemistry, focused on protein biochemistry (structural biology), structure-based drug discovery, protein targets of Mycobacterium tuberculosis and natural products biosynthesis. (Source: Lattes Curriculum)
- Applied structural biology involved in the biosynthesis of natural products: biotechnolgical aplications and study of unusual molecular reactions, AP.R
Abstract
Soil microorganisms are responsible for the production of a large number of antibiotics due to the highly competitive environment for space and nutrients. In addition, we can also use such molecules in the treatment of various illness, including infectious diseases and cancer. Several groups of antibiotics, such as aminoglycosides, changed completely the Medicine because to the benefits...
- Mechanisms of ring formation in inophore polyether tetronates, AP.R
Abstract
Nature has the extraordinary capacity of producing structurally exquisite molecules that possess useful bioactivities for human and animal health. A field of high interest and intense active includes the mechanisms of natural products ring formation because the peculiarity of the involved enzymes. Tetronasin and tetronomycin are tetronate containing natural products, which have similar ...
- Biosynthesis of polyether and aminoglycoside antibiotics: structural investigation of unusual enzymes or with synthetic biology applicability, AP.R
Abstract
Natural products are an important source of molecules that are used by humans to treat various diseases, such as cancer and infectious diseases. These molecules generally are derivatives of secondary metabolism of microorganisms and plants through of sophisticated biosynthetic systems. However, the mechanism of how those enzymes, which are in gene clusters, act to produce specific compo...
- Towards safer aminogrycoside antibiotics: structure, function and engineering studies of key biosynthetic enzymes, AP.R
Abstract
Aminoglycosides are antibiotcs which have a core moiety and various unusual sugars, such as aminosugars and desoxysugars that together with their functional groups are essential for its antibiotic activity, which is the inhibition of protein synthesis due to the interaction with the 305 subunit of bacterial ribosome. Although their toxic effects, aminoglicoside antibiotics are largely p...
(Only some records are available in English at this moment)
- Structural basis of the elongation and cell division control in Mycobacterium tuberculosis and identification of new drug hits based in fragment trials, BP.DD
Abstract
Although the infection caused by Mycobacterium tuberculosis is considered one of the oldest and largely studied disease of humankind, it follows as a leader in both incidence and mortality rates, among bacterial infections. According to the World Health Organization, about 9.6 million of new cases of tuberculosis and 1.5 million of deaths were notified only in 2014. In addition, it is e...
- Purification and crystallization of proteins involved in the biosynthesis of antibiotics, BP.TT
- Fragment based drug discovery applied to Beta-ketoacyl ACP synthase iii from Staphylococcus aureus, BP.IC
Abstract
Staphylococcus aureus infections are a serious problem of public health because of the resistance of this bacteria to most of the in-use antibiotics. Although this microorganism is part of the microbiota, it eventually could cause infections, including cutaneous infections or even cause the death of hospitalized patients due to nosocomial infections. Because of these problems, the resea...
- Preliminary structural analysis of activating nitroreductases of PA-824 compound and delamanid in Mycobacterium Tuberculosis, BP.IC
Abstract
Mycobacterium tuberculosis (Mtb) is the responsible agent of one of the infect-contagious disease with highest mortality indices in the world. With about 9 million of new cases by year, the indices indicate that the occurrence of this disease was never so high, despite prophylaxis strategies such as BCG vaccine and chemotherapy treatment. In Brazil, tuberculosis also deserve attention, ...
(Only some records are available in English at this moment)
- Investigation of the function and requirement of two halogenases from the glycopeptide A47934 biosynthetic gene cluster, BE.EP.MS
Abstract
Organohalogen natural products represent an important role in the research of natural products. Various experiments have shown that natural compounds may have their biologic activity altered by presence of absence of halogen. Glycopeptide antibiotics, such as vancomycin and teicoplanin are halogenated natural products and they have substantial medical importance. They are clinically use...
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 17 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 24 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 10 |
| Citations | 43 |
| Cit./Article | 4.3 |
| Data from Web of Science | |
BERTACINE DIAS, MARCIO VINICIUS; TYRAKIS, PETROS; DOMINGUES, ROMENIA RAMOS; PAES LEME, ADRIANA FRANCO; BLUNDELL, TOM L.. Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, v. 22, n. 1, p. 94-103, JAN 7 2014. Web of Science Citations: 14. (10/15971-3)
DIAS‚ B.; MARCIO‚ V.; ELY‚ F.; PALMA‚ M.S.; DE AZEVEDO‚ W.F.; BASSO‚ L.A.; SANTOS‚ D.S.. Chorismate synthase: an attractive target for drug development against orphan diseases. CURRENT DRUG TARGETS, v. 8, n. 3, p. 437-444, 2007. (01/07532-0)
RIBEIRO MARQUES‚ M.; HENRIQUE PEREIRA‚ J.; OLIVEIRA‚ J.S.; AUGUSTO BASSO‚ L.; FILGUEIRA DE AZEVEDO‚ W.; SANTIAGO SANTOS‚ D.; SERGIO PALMA‚ M.. The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials. CURRENT DRUG TARGETS, v. 8, n. 3, p. 445-457, 2007. (01/07532-0)
LIBREROS-ZUNIGA, GERARDO ANDRES; SILVA, CATHARINA DOS SANTOS; FERREIRA, RAFAELA SALGADO; BERTACINE DIAS, MARCIO VINICIUS. Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics by L,D-Transpeptidase 3 (Ldt(Mt3)) from Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES, v. 5, n. 2, p. 260-271, FEB 2019. Web of Science Citations: 0. (16/18721-4, 10/15971-3, 15/09188-8)
RIBEIRO, JOAO AUGUSTO; CHAVEZ-PACHECO, SAIR MAXIMO; DE OLIVEIRA, GABRIEL STEPHANI; SILVA, CATHARINA DOS SANTOS; PIMENTA GIUDICE, JOAO HENRIQUE; LIBREROS-ZUNIGA, GERARDO ANDRES; BERTACINE DIAS, MARCIO VINICIUS. Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 75, n. 7, p. 682-693, JUL 2019. Web of Science Citations: 0. (13/15906-5, 15/09188-8, 18/00351-1, 14/24486-2, 16/18721-4)
WILSON, CAROLINA; DE OLIVEIRA, GABRIEL S.; ADRIANI, PATRICIA P.; CHAMBERGO, FELIPE S.; DIAS, MARCIO V. B.. Structure of a soluble epoxide hydrolase identified in Trichoderma reesei. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1865, n. 8, p. 1039-1045, AUG 2017. Web of Science Citations: 3. (15/03329-9, 10/15971-3, 15/09188-8, 14/24107-1)
BERTACINE DIAS, MARCIO V.; SANTOS, JADEMILSON C.; LIBREROS-ZUNIGA, GERARDO A.; RIBEIRO, JOAO A.; CHAVEZ-PACHECO, SAIR M.. Folate biosynthesis pathway: mechanisms and insights into drug design for infectious diseases. Future Medicinal Chemistry, v. 10, n. 8, p. 935-959, APR 2018. Web of Science Citations: 5. (10/15971-3, 15/09188-8, 13/15906-5)
CARDOSO, TABATA P.; DE SA, LARISSA A.; BURY, PRISCILA DOS S.; CHAVEZ-PACHECO, SAIR M.; DIAS, MARCIO V. B.. Cloning, expression, purification and biophysical analysis of two putative halogenases from the glycopeptide A47,934 gene cluster of Streptomyces toyocaensis. Protein Expression and Purification, v. 132, p. 9-18, APR 2017. Web of Science Citations: 0. (10/15971-3, 12/23427-7, 12/16631-7)
BURY, PRISCILA DOS SANTOS; HUANG, FANGLU; LI, SICONG; SUN, YUHUI; LEADLAY, PETER F.; BERTACINE DIAS, MARCIO VINICIUS. Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis. ACS Chemical Biology, v. 12, n. 11, p. 2779-2787, NOV 2017. Web of Science Citations: 2. (10/15971-3, 15/09188-8, 14/07843-6, 14/50324-0)
DE OLIVEIRA, GABRIEL S.; ADRIANI, PATRICIA P.; RIBEIRO, JOAO AUGUSTO; MORISSEAU, CHRISTOPHE; HAMMOCK, BRUCE D.; DIAS, MARCIO VINICIUS B.; CHAMBERGO, FELIPE S.. The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. International Journal of Biological Macromolecules, v. 129, p. 653-658, MAY 15 2019. Web of Science Citations: 0. (13/15906-5, 16/12859-4, 15/03329-9, 15/09188-8, 18/00351-1, 14/24107-1, 17/25705-8)
DE ARAUJO, NATALIA CERRONE; BURY, PRISCILA DOS SANTOS; TAVARES, MAURICIO TEMOTHEO; HUANG, FANGLU; PARISE-FILHO, ROBERTO; LEADLAY, PETER; BERTACINE DIAS, MARCIO VINICIUS. Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in the Biosynthesis of Gentamicin. ACS Chemical Biology, v. 14, n. 5, p. 925-933, MAY 2019. Web of Science Citations: 0. (10/15971-3, 15/09188-8, 14/07843-6, 14/50324-0)
LUHAVAYA, HANNA; DIAS, MARCIO V. B.; WILLIAMS, SIMON R.; HONG, HUI; DE OLIVEIRA, LUCIANA G.; LEADLAY, PETER F.. Enzymology of Pyran RingA Formation in Salinomycin Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 54, n. 46, p. 13622-13625, NOV 9 2015. Web of Science Citations: 19. (10/15971-3, 11/17510-6)
(References retrieved automatically from State of São Paulo Research Institutions)
DIAS, Marcio Vinicius Bertacine. Estudo estrutural de proteínas alvo de Mycobacterium tuberculosis. 2007. 125f. Tese (Doutorado) – Instituto de Biociências, Letras e Ciências Exatas. Universidade Estadual Paulista. São José do Rio Preto. (03/12472-2)
GIUDICE, João Henrique Pimenta. Estudo estrutural e biofísico de três enzimas da via do folato de microrganismos patogênicos.. 2018. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (14/24486-2)