CV Lattes
Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Lusiane Maria Bendhack in research grants and scholarships supported by FAPESP.
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The endothelial glycocalyx is formed primarily by proteoglycans, glycoproteins and glycosaminoglycans (GAGs) and it has been described as a structure responsible for mechanotransduction which is a translation of the biomechanical forces in biochemical signaling in endothelial cells, promoting activation of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production. Essentia…
The endothelial dysfunction described in hypertensive subjects has been characterized by reduced endothelium-dependent vasodilatation. However, its role on the contractile response is not clear. The impaired production of relaxing factors, such as Nitric Oxide (NO) and Prostacyclin (PGI2), and contractile factor Thromboxane A2 (TXA2) derived from the endothelium can contribute to endothel…
Nitric oxide (NO) donors has been used in the vascular biology studies in order to understand the physiological role of NO. NO donors like nitroglycerin and sodium nitroprusside (SNP) have been used in the cardiovascular diseases. In vivo and in vitro studies demonstrated important therapeutic limitations of the nitrovasodilators. Nitroglycerin induces tolerance and SNP presents cytotoxic…
(Only some records are available in English at this moment)
Prostacyclin (PGI2) is produced in vascular endothelial cells and acts by IP prostacyclin receptor activation to cause vasodilation and inhibit smooth muscle cell proliferation and platelet aggregation. In addition to nitric oxide (NO), prostanoids play an important role on the vascular tone control. Prostanoids are produced by COX isoforms that metabolize arachidonic acid to PGG2 and PGH…
Nitric oxide (NO) plays a pivotal role on the vascular tone control. NO is synthesized on the endothelial cells by the endothelial nitric oxide synthase (eNOS). Spontaneously hypertensive rat (SHR) vessels are characterized by endothelial dysfunction that leads to decreased NO bioavailability able to induce vasodilatation. Sodium nitroprusside (SNP) is an NO donor that is a pharmacologica…
The 2K-1C renal hypertension model is characterized by activation of the renin-angiotensin-aldosterone system (RAAS). Angiotensin II (Ang II) is the main peptide of RAAS that promotes vascular smooth muscle cells contraction by AT1 receptor activation. AT1 is expressed in endothelial cells and is involved in NADPH-oxidase (NOX) activation, increased production of reactive oxygen species (…
(Only some records are available in English at this moment)
The glycocalyx interacts directly with hemodynamic forces from blood flow and, consequently, is a prime candidate for mechanosensing. We hypothesize that the mechanotransduction pathways activated by increased intravascular pressure in glypican-1 and syndecan-1 knockout mice are impaired when compared to wild-type mice, decreasing nitric oxide synthase activation and nitric oxide producti…
For many years the nitrite was considered an inert metabolite of nitric oxide (NO) pathway. However, it is present in abundance in the blood and tissues and may be the largest intravascular and tissue source of NO storage. NO is one of the smallest and simplest molecules with characteristics that confer high diffusion capacity through the cells. It is classified as a messenger that does n…
| 15 / 11 | Completed research grants |
| 50 / 24 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 67 / 37 | All research grants and scholarships |
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