Manoela Marques Ortega

• Abstract

  Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. Patients with GBM have a median survival of about 14 months, despite aggressive treatment. Due to the clinical and pathological heterogeneity of the GBM, there are many recent attempts to better understand and characterize these tumors at the genetic and molecular level. The goal of this study is to identify s…

  Identification of single-nucleotide polymorphisms in microRNAs involved with the glioblastoma susceptibility, AP.R

• Abstract

  Epilepsy has been described as the fourth most common neurological disease, affectting until 2% of world population that represents around 50 milions of patients. The authors showed a gap in the literature regarding the evaluation of the susceptibility of the epileptic development and the characterization of genetic alterations in the epileptic tissue. Although some studies have described…

  Characterization of a single nucleotide polymorphism in the microRNA-146a and epilepsy susceptibility, BP.IC

• Abstract

  Glioblastoma multiforme (GBM) accounts for 15-20% of neurological tumors and being considered the most aggressive. Biological heterogeneity and resistance to chemotherapy are the major obstacles facing the development of effective treatment for GBM. Several genes and signaling pathways have been identified to be responsible for the aggressive phenotype of this tumor. The NF-ºB pathway is …

  Identification and characterization of microRNAs involved in inhibition of the NF-kB signaling pathway by the action of glycyrrhizinate dipotassium in glioblastoma multiforme cell lines, BP.MS

• Abstract

  Glioblastoma multiforme (GBM) represents a significant portion of neurological tumors. It is characterized by poorly differentiated neoplastic astrocytes with areas of vascular proliferation and necrosis. The survival rate of the patients is inversely proportional to the degree of the tumor, where grade IV is the most aggressive with a relatively short prognosis. Biological heterogeneity …

  Identification and characterization of single-nucleotide polymorphisms in microRNAs involved in glioblastoma susceptibility patients, BP.MS

(Only some records are available in English at this moment)