Graduated in Chemistry from the University of São Paulo (1979), Master in Biochemistry from the University of São Paulo (1981), PhD in Biochemistry from the University of São Paulo (1986). Postdoctorate at the University of Düsseldorf, Germany (1986-1988). Currently is a full professor at the University of São Paulo. It has a contribution in the area of redox stress, mainly in studies on DNA modification promoted by aldehydes. The possible role of aldehydes has been increasingly investigated in cancer induction promoted by urban pollution. Epidemiological and pathophysiological studies also support the association between air pollution and mortality and morbidity from other causes, mainly, but not exclusively, of respiratory and cardiovascular diseases. Unraveling the mechanisms of modification in biomolecules by exogenous and endogenous aldehydes opens perspectives for a better control of exposure to these agents. In addition to characterizing the aldehyde DNA reaction products, the group developed ultrasensitive LC-based techniques coupled with mass spectrometry to detect these products in biological fluids pointing to the possibility of their use as exposure biomarkers. The group also investigates the role of aldehydes when formed endogenously in neurodegenerative diseases and cardiac ischemia. Scientific production in January 2019: 193 scientific publications and 4781 citations and h index = 40. (Source: Lattes Curriculum)
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The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
Several processes including oxidative metabolism, inflammation, exposure to physical agents such as UV light and ionizing radiation produce reactive intermediates capable of producing damage to biomolecules. The increase in these lesions has been linked with a variety of diseases as cancer and aging. In recent years there has been a major advance in available technology, especially mass s…
A very large body of studies has focused on the role of redox-dependent mechanisms in a broad variety of disease conditions including cancer. A basic and prime drawback that prevents a better understanding of redox pathophysiology is the overall difficulty and the almost lack of availability of adequate indexes to quantitatively assess the redox status of in vivo systems, including cells,…
The role of DNA etheno adducts in mutagenic and carcinogenic processes triggered by known occupational and environmental carcinogens, such as vinyl chloride and ethyl carbamate, has been well investigated. 1,N6-Etheno-2 -deoxyadenosine (?dAdo), 3,N4-etheno-2 -deoxycytidine (?dCyd) and N2,3-ethenoguanine (N2,3-?G) have already been detected in different tissues of rats exposed to vinyl ch…
(Only some records are available in English at this moment)
Unsaturated aldehydes are reactive species capable of reacting with lipids, proteins, and DNA. Various pieces of evidence point to the involvement of reactive aldehydes in the progression of pathologies such as cardiovascular diseases, arteriosclerosis, and neurodegenerative diseases. A central goal of our project is to study the chemical reactivity of redox intermediates in biological en…
Alcohol consumption is associated with the development of several types of cancer. The mechanisms involved in this process are not fully understood, but the formation of acetaldehyde derived from ethanol seems to play an important role. In populations deficient in aldehyde dehydrogenase, high levels of acetaldehyde have been associated with an increased risk of esophageal cancer after alc…
The pathophysiology of Amyotrophic Lateral Sclerosis (ALS) has recently established that the formation and accumulation of aldehydes resulting from mitochondrial dysfunction, and consequent excessive lipid peroxidation, are extremely neurotoxic and associated with the appearance of symptoms and progression of ALS in preclinical models. Among different enzymes responsible for cellular deto…
(Only some records are available in English at this moment)
Acetaldehyde produced endogenously or by exogenous exposure is associated with several pathophysiological processes. Accumulation of endogenous aldehydes leads to genotoxicity. Aldehydes react with amine and thiol groups of proteins, nucleic acids and some lipids and promote changes in these biomolecules. Recently, a pathway for the production of acetaldehyde via ketoacid dehydrogenases, …
Redox stress is associated with several toxicological and pathophysiological processes. Several combined processes used as possible biomarkers of this process were differentiated, being able to alkylate biomolecules such as DNA and proteins. These are important in cellular activity. In order to avoid the deleterious effects these aldehydes are detoxified enzymatically or through glutathio…
Outdoor air pollution is classified by the International Agency for Research on Cancer (IARC) as carcinogenic to humans (IARC, 2016). A study based on 3-D atmospheric models shows the overall increase in the concentration of acetaldehyde in the coming years due to the increasing use of fuels such as ethanol and gasoline (Millet et al, 2010). Acetaldehyde reacts with 2'-deoxyguanosine (dGu…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 30 / 10 | Completed scholarships in Brazil |
| 44 / 20 | All research grants and scholarships |
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CV Lattes
ORCID