CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Aníbal Eugênio Vercesi in research grants and scholarships supported by FAPESP.
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In the last 40 years, it has become evident that mitochondria are involved in many cell functions besides energy conversion, such as the control of cell death via calcium and oxygen and nitrogen reactive species signaling. Elevated levels of calcium in the mitochondrial matrix stimulate the generation of reactive oxygen which promote the opening of an unspecific pore in the inner mitochon…
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected t…
This proposal concerns a joint research project of the groups of Prof. Anibal Vercesi (Department of Clinical Pathology) and the research group of Prof. Pedro L.O. Volpe (Institute of Chemistry, Unicamp) with the group of Prof. Johannes Lerchner (TU Bergakademie Freiberg, Germany) to develop new chip calorimetry based methods for the investigation of the energy metabolism of Trypanosoma c…
Mais de 500 proteínas quinases estão presentes no genoma humano, atuando como chaves regulatórias de praticamente todos os processos fisiológicos do organismo humano. As quinases podem ser moduladas através de pequenas moléculas químicas altamente potentes. No entanto, apesar de sua importância e adequação para a descoberta de fármacos, a maioria das pesquisas acadêmicas e farmacêuticas t…
In addition to be the cell’s powerhouse, mitochondria also contains a cell death machinery. Indeed, after a number of new mitochondrial proteins and modulator metabolites have been discovered, this organelle has emerged as a center of attention in processes of cell signaling, cell injury and cell death. Evidence has been provided that mitochondria comprise one of the main pathways for cel…
(Only some records are available in English at this moment)
We will study the role of mitochondrial NAD(P)-transhydrogenase (NNT) activity in the development of Fatty Liver Disease and aging in mice. It will be investigated the role of pyruvate dehydrogenase inhibition in the development of Fatty Liver Disease in NNT deficient mice fed a high fat diet. Additionally, the involvement of NNT activity will be evaluated in the process of mitochondrial …
The parasite Trypanosoma cruzi is the etiological agent of Chagas Disease. The existing drugs have low effectiveness and high toxicity. Structural and functional studies of several proteins are underway, and they are a powerful tool in the identification and development of new chemotherapy targets. Recognized molecular targets for new chemotherapies are the proteins involved in the regula…
Brazil follows the worldwide trend of a marked increase in the number of elderly people in the population. Therefore, factors associated with aging are drawing attention, due to the relationship of aging with chronic diseases, elderly life quality, medical assistance costs and mortality risk. Many aging studies using model organisms focus on the mitochondria, multifunctional organelles th…
(Only some records are available in English at this moment)
Aging is commonly defined as an overall progressive functional decline in organisms over time with an increasing risk of disease and death. At the molecular level, aging is attributed to the accumulation of stochastic damage to tissues and cellular components. The free radical theory of aging, proposed by Harman, postulated that both aging and degenerative disease are caused by the accumu…
The lipid droplets (LDs) store triglycerides (TG) and release fatty acids in response to nutrient and hormonal signals, effectively maintaining energy reserves and buffering the cell from fatty acid toxicity. The imbalance between the lipid biogenesis, cellular uptake and the energy storage cause hepatic steatosis and macrophage foam cell formation. Lipid synthesis and lipid droplets form…
The lipid droplets (LDs) store triglycerides (TG) and release fatty acids in response to nutrient and hormonal signals, effectively maintaining energy reserves and buffering the cell from fatty acid toxicity. The imbalance between the lipid biogenesis, cellular uptake and the energy storage cause hepatic steatosis and macrophage foam cell formation. Lipid synthesis and lipid droplets form…
| 2 / 2 | Ongoing research grants |
| 28 / 12 | Completed research grants |
| 42 / 11 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 75 / 28 | All research grants and scholarships |
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