Associate Professor, Department of Biochemistry, Institute of Chemistry, USP. Graduated in Pharmacy and Biochemistry from the University of São Paulo. JICA trainee at National Food Research Institute (Tsukuba, Japan 1996-1998). Master in Nutrition from Faculty of Medicine - University of Tokushima (1998-2001). PhD in Biochemistry from the Department of Biochemistry-Chemistry Institute, University of Sao Paulo (2001-2005). Member of the Council of the Society for Redox Biology and Medicine (SfRBM since 2020) and Directory of SBBQ (since 2021). Has experience in the area of modified lipids, synthesis of bioactive oxidized lipids, characterization of modifications in proteins and peptides, lipidomics and oxy-lipidomics analysis. The laboratory uses techniques based on mass spectrometry and computational tools. The laboratory's current focus has been the investigation of changes in lipid and redox metabolism associated with aging and inflammation in the context of neurodegenerative diseases, cancer, and infectious diseases. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Bioquímicos detectan alteraciones en la retina asociadas a la ceguera en bebés prematuros |
| Biochemists identify retinal changes associated with blindness in preterm infants |
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| News published in Agência FAPESP Newsletter about the researcher |
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The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
The amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by death of motor neurons in brain and spinal cord, leading to muscular atrophy, paralysis, and death. Importantly, alterations in lipid metabolism due to chronic inflammation and oxidative stress are strongly linked to ALS. The central nervous system (CNS) is enriched in polyunsaturated fatty acids (PUF…
Aging is a risk factor for the development and intensification of several diseases including viral infections such as that caused by Sars-Cov-2. Lipids are very important molecules. They act in inflammatory signaling and are also a source for viral replication. Lipids are necessary to produce double-layer membranes (DMVs) that will protect the virus from the host's immune system. Consider…
In mammals, formation and detoxification of oxidized lipids are catalysed, among other enzymatic systems, by lipoxygenases and peroxidases, respectively. Some human lipoxygenases, including 5-lipoxygenase (5-LOX) and 15-lipoxygenases (15-LOX-1 and 15-LOX-2), participate in the biosynthesis of pro-inflammatory and pro-resolution lipid mediators and play important roles as modulators of inf…
Ferroptosis is a type of non-apoptotic cell death characterized by iron-dependent lipid peroxidation. Recent studies show a close relationship between cholesterol metabolism, lipid droplet accumulation and sensitivity to ferroptosis, however, little is known about its impact on brain cells. This project aims to evaluate the role of lipids such as free and esterified cholesterol, in additi…
Linoleic acid (LA) is a polyunsaturated fatty acid (PUFA) of the omega-6 family that can be found in many foods and vegetable oils. Due to the growth in soy production and consumption of processed foods, LA consumption has grown exponentially since the beginning of the 20th century. Once obtained from the diet, LA can be stored in lipid2 droplets in the form of triacylglycerol or choleste…
Oxidative stress and inflammation are closely linked to infectious and neurodegenerative processes. Polyunsaturated fatty acids (PUFAs), such as arachidonic (ARA, n-6) and docosahexaenoic (DHA, n-3) acids play a pivotal role in this event as precursors of pro-inflammatory or pro-resolving oxidized products. During an infectious or neurodegenerative process, a set of signaling oxylipids ar…
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Respiratory infections caused by coronavirus were responsible for three outbreaks in 2003, 2012 and 2019. Covid-19 caused by Sars-Cov-2 was responsible for more than 6.9 million deaths. The understanding of virus metabolism in the organism could lead to the production of new drugs that prevent viral contamination at pandemic levels. Lipid metabolism have been showing high relevance for vi…
Oxidized lipids are frequently linked to pathological conditions due to their role as modulators of inflammation and oxidative stress. More recently, oxidized lipids have been reported as key regulators of ferroptosis, a form of regulated cell death triggered by accumulation of lipid hydroperoxides in the cell membrane. Ferroptosis is under intensive investigation in diseases, with cancer…
Cholesterol is a neutral lipid widely found in the cell membrane, where it influences in the membrane fluidity, organization and in cell signaling events. Since cholesterol is known to play structural and regulatory functions in the membrane, its physiological concentration is strictly controlled by the cell. An increase in the mitochondrial cholesterol, for instance, has been associated …
| 1 / 1 | Ongoing research grants |
| 4 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 13 / 9 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 24 / 17 | All research grants and scholarships |
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