Maria José Soares Mendes Giannini

• Abstract

  The present proposal aims to strengthen the infrastructure of the Laboratory of Alternative Methods and Bioproducts (LaMABio), affiliated with the School of Pharmaceutical Sciences of UNESP - Araraquara, through the acquisition of strategic equipment: a microinjector for Danio rerio (zebrafish) embryos, an inverted fluorescence microscope (ZEISS), and two shakers with temperature control.…

  Compliance with the 3Rs principles - Category C. Acquisition of permanent equipment for the improvement of installations of the Laboratory of Alternative Methods and Bioproducts (LaMABio) to the School of Pharmaceutical Sciences-UNESP., AP.PI

• Abstract

  Dermatophytes are fungi that affect keratinized tissues such as skin, hair, and nails, causing dermatophytoses. The main agents can be anthropophilic (Trichophyton rubrum and the Trichophyton mentagrophytes/T. interdigitale complex) and zoophilic (Microsporum canis). In some cases, the lesions of these fungi are associated with bacteria and yeasts, resulting in an aggravated infectious co…

  Study of the pathogenesis of mono/polymicrobial dermatophytes biofilms in ex vivo models and application of control strategies., AP.R

• Abstract

  Dermatophytes, fungi that cause dermatophytosis, can invade keratinized tissues in humans and animals. The biolm-forming ability of these fungi was described recently, and it may be correlated with the long treatment period and common recurrences of this mycosis. In this study, we evaluated the anti-dermatophytic and anti-biolm activity of 2- hydroxychalcone (2-chalcone) in the dark and p…

  2-hidroxichalcona como um composto potente e fotossensibilizador contra biofilmes de dermatófitos, PUB.ART

• Abstract

  Fungal infections are neglected by the social and political point of view. However, these affect more than one billion people, resulting in approximately 11.5 million deadly infections and more than 1 to 5 million deaths per year. Despite advances in several public health areas, many pathogens remain important because of their pathogenicity and represent an important source of infection f…

  Functional characterization of genes related to the biofilm formation in the fungal pathogens Histoplasma capsulatum and Paracoccidioides brasiliensis, AP.R SPRINT

(Only some records are available in English at this moment)

• Abstract

  Dermatophytes are keratinophilic filamentous fungi that cause dermatophytosis, and the main etiological agents can be anthropophilic and zoophilic. Several virulence factors are involved in the pathogenesis of dermatophytosis, including the formation of fungal biofilms. Additionally, the lesions caused by these fungi can be associated with bacterial and yeast coinfections, resulting in a …

  Expression of Trichophyton rubrum biomarkers in mono and poli-species biofilms in reconstructed skin and spheroids models, and forms of control., BP.DD

• Abstract

  Candidozyma auris, formerly Candida auris, has emerged as a significant pathogen over the past decade, being responsible for severe invasive infections with high mortality rates. It stands out for its resistance to available antifungal agents and the difficulty of surface disinfection, leading to its inclusion in the World Health Organization (WHO) list of priority pathogens. The species …

  Study of Candidozyma auris colonization with skin bacteria in mono- and mixed-species biofilms using three-dimensional models and antifungal susceptibility, BP.DD

• Abstract

  Onychomycosis is one of the most prevalent fungal infections in the population, leading to various clinical manifestations in the nails. Among the pathogens, dermatophyte infection predominates, with Trichophyton rubrum being the most frequent species found, followed by the Trichophyton mentagrophytes complex. The infection affects the nail unit, causing thickening that makes it difficult…

  Antifungal evaluation of the association of terbinafine with potential antifungals encapsulated in nanostructured lipid carriers and incorporated in hydrogels against biofilms in onychomycosis models, BP.PD

(Only some records are available in English at this moment)

• Abstract

  Paracoccidioidomycosis is a systemic mycosis caused by the thermodimorphic pathogenic fungus ofthe genus Paracoccidioides. It is considered a neglected tropical disease of great importance in Latin American countries, mainly affecting rural workers. Several factors determining virulence, such as dimorphism, changes in cell wall composition, adhesins, and biofilm formation, have been repor…

  EVALUATION OF BIOFILM FORMATION of Paracoccidioides brasiliensis IN A THREE-DIMENSIONAL SPHEROID MODEL IN REGARD TO THE ROLE OF ADHESINS 14-3-3 AND METHODS OF CONTROL., BP.MS

• Abstract

  Dermatophytes are filamentous keratinophilic fungi, agents of dermatophytosis, also more commonly known as "tinha" or "tinea," mycoses with a high global incidence capable of developing exclusively on tissues with keratin, such as nails, hair, and skin. The main agents can be anthropophilic and zoophilic. Several virulence factors are involved in the pathogenicity of dermatophytosis. The …

  Biofilm development on 3D skin infected by Trichophyton rubrum and analysis of gene expression by real-time PCR, BP.IC

• Abstract

  Dermatophytes are fungi that infect keratinized tissues such as skin, hair, and nails, causing dermatophytosis. There is an association between these fungi' lesions with bacteria, in some cases, making treatment more difficult in some cases. Such infections have a high global incidence and are of great interest to public health. Although some of these fungi can form monospecies biofilms, …

  Monospecies and mixed biofilms of Trichophyton and Staphylococcus: influence of nutrients and presence of persister cells, BP.MS

(Only some records are available in English at this moment)