CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Alemanha
graduated in Biology (Diplom) at the Georg August Universität Göttingen (1991) and received his Dr. rer. nat. at the Department of Medizinische Mikrobiologie at the Universität Göttingen (1995). Has experience in Parasitology, focusing on Parasite Protozoology, acting on the following subjects: malaria, plasmodium, antigenic variation (PfEMP1, RIFIN) and mechanisms orchestrating antigenic variation. Another line of research focuses on new vehicles for delivery of proteins/DNA or RNA to cells for vaccine purposes. (Source: Lattes Curriculum)
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Malaria parasites strictly control gene expression in each phase of their complex life cycle, depending on the host environment. The control of expression is mostly at the transcriptional level, although post-translational mechanisms are also encountered (e.g. P-bodies). Transcriptional control is exerted by dynamic chromatin modification and the deliberate inhibition of chromatin modifie…
Plasmodium falciparum, the most virulent human malaria parasite, contains several variant antigen encoding gene families, which are either virulence-related or have unknown functions. These families include var, rif/stevor and surf families, besides others. All families have in common that their expression is strictly controlled, meaning that one or a few alleles are transcriptionally act…
All species of the malaria-causing protozoan Plasmodium studied so far possess gene families in their genome, some of which encode variant antigens associated to virulence and localize to the infected red blood cell surface. In Plasmodium falciparum, the most important gene families are the var genes which encode the cytoadherence-mediating PfEMP1 antigens, the rif genes encoding RIFIN an…
(Only some records are available in English at this moment)
In this project we propose the use of RNA replicons encapsulated in cationic liposomes as a delivery method that should be able to generate in vitro and in vivo therapeutic effects. At first, the cationic liposomes will be analyzed regarding their physicochemical properties such as charge, size and ability to protect the encapsulated RNA. Afterwards, assays will be performed with liposome…
An alternative to the use of inactivated or attenuated whole organisms or recombinant proteins as vaccines is the use of plasmid DNAs which encode the desired vaccine antigen. Genetic vaccines and delivery of drugs to specific tissues have two great challenges: 1-Delivery of sufficient quantities of RNA or DNA to develop immune responses against specific vaccine targets and side effects p…
The protozoan parasite Plasmodium falciparum causes the most severe form of human malaria and the most vulnerable persons are children under the age of 5 years and pregnant women. To evade the constantly evolving host immune response to infection, asexual parasite forms use antigenic variation of virulence-associated genes and sexual differentiation as a strategy to survive and secure the…
(Only some records are available in English at this moment)
This is a proposal for a 6-month research internship at the Institute of Biodiversity, Animal Health and Comparative Medicine in the University of Glasgow under the supervision of Dr. Lisa Ranford-Cartwright. The main aim of this project is the infection of Anopheles mosquitoes with transgenic strains (knockdown / knockout) of Plasmodium falciparum, in order to evaluate the role of two tr…
| 10 / 5 | Completed research grants |
| 20 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 31 / 14 | All research grants and scholarships |
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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 14 |
| Citations | 20 |
| Cit./Article | 1.4 |
| Data from Web of Science | |
CUBILLOS, ELIANA F. G.; PRATA, ISADORA OLIVEIRA; FOTORAN, WESLEY LUZETTI; RANFORD-CARTWRIGHT, LISA; WUNDERLICH, GERHARD. The Transcription Factor PfAP2-O Influences Virulence Gene Transcription and Sexual Development in Plasmodium falciparum. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, JUN 28 2021. Web of Science Citations: 0. (16/19145-7, 15/17174-7, 16/12659-5, 17/24267-7)
WESLEY L. FOTORAN; NICOLE KLEIBER; THOMAS MÜNTEFERING; EVA LIEBAU; GERHARD WUNDERLICH. Production of glycosylphosphatidylinositol-anchored proteins for vaccines and directed binding of immunoliposomes to specific cell types. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, p. -, 2020. Web of Science Citations: 0. (15/17174-7)
DOMBROWSKI, JAMILLE GREGORIO; BARATEIRO, ANDRE; MACHADO PEIXOTO, ERIKA PAULA; CLAUDIO DA SILVA BARROS, ANDRE BOLER; DE SOUZA, RODRIGO MEDEIROS; CLARK, TAANE GREGORY; CAMPINO, SUSANA; WRENGER, CARSTEN; WUNDERLICH, GERHARD; PALMISANO, GIUSEPPE; et al. Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon. PLoS Neglected Tropical Diseases, v. 15, n. 4, APR 2021. Web of Science Citations: 0. (17/03966-4, 17/03939-7, 18/18257-1, 19/12068-5, 15/26722-8, 17/24267-7, 18/20468-0, 20/04923-0, 18/15549-1, 17/05782-8)
FOTORAN, WESLEY LUZETTI; KLEIBER, NICOLE; GLITZ, CHRISTIANE; WUNDERLICH, GERHARD. A DNA Vaccine Encoding Plasmodium falciparum PfRH5 in Cationic Liposomes for Dermal Tattooing Immunization. VACCINES, v. 8, n. 4, DEC 2020. Web of Science Citations: 0. (15/17174-7, 17/24267-7)
FOTORAN, WESLEY L.; COLHONE, MARCELLE C.; CIANCAGLINI, PIETRO; STABELI, RODRIGO G.; WUNDERLICH, GERHARD. Merozoite-Protein Loaded Liposomes Protect against Challenge in Two Murine Models of Plasmodium Infection. ACS BIOMATERIALS SCIENCE & ENGINEERING, v. 2, n. 12, p. 2276-2286, DEC 2016. Web of Science Citations: 2. (12/23306-5, 15/17174-7, 12/18617-1)
MACEDO-SILVA, TATIANE; DUQUE ARAUJO, ROSANA BEATRIZ; MEISSNER, KAMILA ANNA; FOTORAN, WESLEY LUZETTI; MEDEIROS, MARCIA MELO; DE AZEVEDO, MAURO FERREIRA; WUNDERLICH, GERHARD. Knockdown of the Plasmodium falciparum SURFIN4.1 antigen leads to an increase of its cognate transcript. PLoS One, v. 12, n. 8, AUG 11 2017. Web of Science Citations: 0. (15/17174-7, 12/23306-5, 13/12439-7, 15/19316-3)
CARLOS, BIANCA C.; FOTORAN, WESLEY L.; MENEZES, MARIA J.; CABRAL, FERNANDA J.; BASTOS, MARCELE F.; COSTA, FABIO T. M.; SOUSA-NETO, JAYME A.; RIBOLLA, PAULO E. M.; WUNDERLICH, GERHARD; FERREIRA, MARCELO U.. Expressed var gene repertoire and variant surface antigen diversity in a shrinking Plasmodium falciparum population. Experimental Parasitology, v. 170, p. 90-99, NOV 2016. Web of Science Citations: 2. (09/17114-3, 10/50333-8)
DUQUE ARAUJO, ROSANA BEATRIZ; SILVA, TATIANE MACEDO; KAISER, CHARLOTTE SOPHIE; LEITE, GABRIELA FERNANDES; ALONSO, DIEGO; MARTINS RIBOLLA, PAULO EDUARDO; WUNDERLICH, GERHARD. Independent regulation of Plasmodium falciparum rif gene promoters. SCIENTIFIC REPORTS, v. 8, JUN 19 2018. Web of Science Citations: 0. (15/17174-7, 12/23306-5)
FOTORAN, WESLEY L.; MUENTEFERING, THOMAS; KLEIBER, NICOLE; MIRANDA, BEATRIZ N. M.; LIEBAU, EVA; IRVINE, DARRELL J.; WUNDERLICH, GERHARD. A multilamellar nanoliposome stabilized by interlayer hydrogen bonds increases antimalarial drug efficacy. Nanomedicine-Nanotechnology Biology and Medicine, v. 22, NOV 2019. Web of Science Citations: 3. (17/08626-7, 17/24267-7, 16/19145-7, 15/17174-7)
FOTORAN, WESLEY L.; SANTANGELO, RACHELE; DE MIRAND, BEATRIZ N. M.; IRVINE, DARRELL J.; WUNDERLICH, GERHARD. DNA-Loaded Cationic Liposomes Efficiently Function as a Vaccine against Malarial Proteins. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, v. 7, p. 1-10, DEC 2017. Web of Science Citations: 4. (15/17174-7, 12/18617-1)
CABRAL, FERNANDA J.; VIANNA, LUCIANA G.; MEDEIROS, MARCIA M.; CARLOS, BIANCA CECHETTO; MARTHA, ROSIMEIRE D.; SILVA, NADIA MARIA; DA SILVA, LUIZ HILDEBRANDO P.; STABELI, RODRIGO G.; WUNDERLICH, GERHARD. Immunoproteomics of Plasmodium falciparum-infected red blood cell membrane fractions. Memórias do Instituto Oswaldo Cruz, v. 112, n. 12, p. 850-856, DEC 2017. Web of Science Citations: 2. (12/23306-5)
RODRIGUES-JESUS, M. J.; FOTORAN, W. L.; CARDOSO, R. M.; ARAKI, K.; WUNDERLICH, G.; FERREIRA, LUIS C. S.. Nano-multilamellar lipid vesicles (NMVs) enhance protective antibody responses against Shiga toxin (Stx2a) produced by enterohemorrhagic Escherichia coli strains (EHEC). Brazilian Journal of Microbiology, v. 50, n. 1, p. 67-77, JAN 2019. Web of Science Citations: 1. (14/21141-4, 15/17174-7)
BILSLAND, ELIZABETH; VAN VLIET, LIISA; WILLIAMS, KEVIN; FELTHAM, JACK; CARRASCO, MARTA P.; FOTORAN, WESLEY L.; CUBILLOS, ELIANA F. G.; WUNDERLICH, GERHARD; GROTLI, MORTEN; HOLLFELDER, FLORIAN; et al. Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan. SCIENTIFIC REPORTS, v. 8, JAN 18 2018. Web of Science Citations: 6. (15/19103-0, 15/03553-6, 12/23306-5)
GÖLNITZ‚ U.; ALBRECHT‚ L.; WUNDERLICH‚ G.. Var transcription profiling of Plasmodium falciparum 3D7: assignment of cytoadherent phenotypes to dominant transcripts. Malaria Journal, v. 7, n. 1, p. 14, 2008.
MACEDO-SILVA, TATIANE; DESAI, SANJAY A.; WUNDERLICH, GERHARD. Improved Plasmodium falciparum dilution cloning through efficient quantification of parasite numbers and c-SNARF detection. Malaria Journal, v. 20, n. 1, JUN 23 2021. Web of Science Citations: 0. (17/24267-7)
(References retrieved automatically from State of São Paulo Research Institutions)
FRATUS, Alessandra Sampaio Bassi. Expressão e reconhecimento imune de alelos conservados de antígenos variantes de Plasmodium falciparum.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (06/02143-0)
MEDEIROS, Marcia Melo. Perfil da resposta imune humoral de pacientes sintomáticos e assintomáticos para malária falciparum, da Amazônia Ocidental Brasileira, contra antígenos polimórficos exportados para a superfície da hemácia infectada e antígenos exportados para a superfície da hemácia infectada e antígenos expressos no merozoíto.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (06/56241-2)
SILVA, Tatiane Macedo. Estudo do modo de transcrição e expressão dos genes surf de Plasmodium falciparum.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (13/12439-7)
ALBRECHT, Letusa. Análise do repertório de genes variantes de Plasmodium falciparum da amazônia e identificação de genes variantes relacionados ao fenótipo de citoaderência a ICAM1 de isolados de Rondônia.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (03/03517-2)
FRATUS, Alessandra Sampaio Bassi. Casos assintomáticos de malária na Amazônia Brasileira: citoaderência, anticorpos contra a superfície da hemácia infectada e proteção em infecções naturais por Plasmodium falciparum.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (08/58677-8)
FOTORAN, Wesley Luzetti. Avaliação do potencial vacinal de nanopartículas carregadas com componentes de merozoitas e esquizontes no modelo murino da infecção com Plasmodium.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/03073-3)
FOTORAN, Wesley Luzetti. Análise do papel de genes bir no processo adaptativo ao hospedeiro e desenvolvimento de proteolipossomos para potencial uso vacinal com foco em reinvasão sanguinea de Plasmodium.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (12/18617-1)