CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Alemanha
graduated in Biology (Diplom) at the Georg August Universität Göttingen (1991) and received his Dr. rer. nat. at the Department of Medizinische Mikrobiologie at the Universität Göttingen (1995). Has experience in Parasitology, focusing on Parasite Protozoology, acting on the following subjects: malaria, plasmodium, antigenic variation (PfEMP1, RIFIN) and mechanisms orchestrating antigenic variation. Another line of research focuses on new vehicles for delivery of proteins/DNA or RNA to cells for vaccine purposes. (Source: Lattes Curriculum)
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All species of Plasmodium encode variant gene families in their genome, which possess different purposes and often relate to immune invasion or pathogenic processes. In recent years, data accumulated pointing to a complex network of regulation of variant gene families at a transcriptional and post-transcriptional level. We have invested in the function of specific putative plant-like tran…
Malaria parasites strictly control gene expression in each phase of their complex life cycle, depending on the host environment. The control of expression is mostly at the transcriptional level, although post-translational mechanisms are also encountered (e.g. P-bodies). Transcriptional control is exerted by dynamic chromatin modification and the deliberate inhibition of chromatin modifie…
Plasmodium falciparum, the most virulent human malaria parasite, contains several variant antigen encoding gene families, which are either virulence-related or have unknown functions. These families include var, rif/stevor and surf families, besides others. All families have in common that their expression is strictly controlled, meaning that one or a few alleles are transcriptionally act…
(Only some records are available in English at this moment)
During the intraerythrocytic phase, the human malaria parasite Plasmodium falciparum exports several proteins to the surface of infected red blood cells. Among these proteins are members of the 45-90 alleles of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of proteins. These are important virulence factors because they cause cytoadherence and sequestration of in…
The human malaria parasite Plasmodium falciparum expresses protein of the type PfEMP, which are variant proteins of the infected erythrocyte, which act as ligands for the endothelial receptors in capillaries, leading to the sequestration of erythrocytes as well as a malaria grave. Despite the advances made, the factors that orchestrate a mono-allelic expression of the "var" genes that enc…
An alternative to the use of inactivated or attenuated whole organisms or recombinant proteins as vaccines is the use of plasmid DNAs which encode the desired vaccine antigen. Genetic vaccines and delivery of drugs to specific tissues have two great challenges: 1-Delivery of sufficient quantities of RNA or DNA to develop immune responses against specific vaccine targets and side effects p…
In this project we propose the use of RNA replicons encapsulated in cationic liposomes as a delivery method that should be able to generate in vitro and in vivo therapeutic effects. At first, the cationic liposomes will be analyzed regarding their physicochemical properties such as charge, size and ability to protect the encapsulated RNA. Afterwards, assays will be performed with liposome…
(Only some records are available in English at this moment)
This is a proposal for a 6-month research internship at the Institute of Biodiversity, Animal Health and Comparative Medicine in the University of Glasgow under the supervision of Dr. Lisa Ranford-Cartwright. The main aim of this project is the infection of Anopheles mosquitoes with transgenic strains (knockdown / knockout) of Plasmodium falciparum, in order to evaluate the role of two tr…
| 11 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 21 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 34 / 17 | All research grants and scholarships |
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