CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Mari Cleide Sogayar - Bolsa de Productivdade do CNPq Nível 1A Graduação em Ciências Biológicas pela Universidade de São Paulo (1968); Mestrado (Master of Sciences) no Biology Dept - University of California (1973) Doutorado em Bioquímica pelo Instituto de Química da Universidade de São Paulo (1977) Pós-doutorado no Dana Farber Cancer Institute, Harvard Medical School, Boston, EUA (1982-84). 1980-2013: Instituto de Química, Dept. Bioquímica, Universidade de São Paulo. 2000-2013: Professora Titular do Depto. de Bioquímica, Instituto de Química, Universidade de São Paulo. Experiência na área de Bioquímica, com ênfase em Biologia Celular e Molecular e Biotecnologia, atuando principalmente nos seguintes temas: a)Controle de proliferação celular e origem de neoplasias, utilizando técnicas de genômica, transcriptômica, genômica funcional e proteômica; b)Diferenciação de células-tronco visando regeneração e reparo de tecidos; c)Terapia Celular baseada em células-tronco e adultas aplicada a doenças degenerativas (transplante clínico de ilhotas pancreáticas humanas em pacientes portadores de diabetes tipo 1 hiperlábil) e engenharia de tecidos. d)Produção de proteínas recombinantes em sistemas de expressão heteróloga (bactérias, células de mamíferos e sistema de baculovírus/células de inseto) para a geração de biofármacos recombinantes como: prolactina humana, leptina humana, hormônio folículo estimulante FSH humano e bovino, amilina/IAPP humana, Fatores de coagulação humanos FVIII, FIX e von Willebrand, Proteínas Morfogenéticas de Osso - BMPs 2, 4 e 7 para reparo ósseo, platelet-derived growth factor humano PDGF, vascular endothelial growth factors VEGFs, basic fibroblast growth factor bFGF, granulocyte and granulocyte and macrophage colony-stimulating factors G- and GM-CSFs, R-Spondin, entre outros. Formou 41 Doutores e 14 Mestres, supervisionou mais de 30 pesquisadores pós-doutores e ofereceu treinamento para mais de 40 alunos de Iniciação Científica. Coordena as atividades do grupo NUCEL (Núcleo de Terapia Celular e Molecular) da Universidade de São Paulo (www.nucel.prp.usp.br). (Source: Lattes Curriculum)
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NUCEL was structured as a translational research Center, having as its mission to act in the Cell and Molecular Therapy area, starting from basic Science centered on molecular mechanisms of cell proliferation and differentiation control and the origin of malignancy to transform the knowledge generated on the bench into products and processes which may be utilized both in medical, odontolo…
Endometriosis is a benign gynecologic disorder characterized by the ectopic growth of misplaced endometrial cells. The retrograde menstruation theory, also known as Sampson's theory, proposes that viable endometrial tissue is refluxed through the fallopian tubes during menstruation and implants on peritoneal surface or pelvic organs. This peritoneal reflux could be a necessary but not suf…
(Only some records are available in English at this moment)
Diabetes mellitus (DM) is a metabolic syndrome with high global prevalence, considered one of the greatest public health emergencies of the 21st century. It is among the top 10 leading causes of death worldwide, and its increasing incidence is linked to modern lifestyles, such as poor diets, sedentary behavior, and obesity. DM is responsible for more than 80% of premature deaths globally,…
Breast cancer has a high incidence and lethality in women in Brazil and around the world. More than 73 thousand new cases were estimated for the three-year period 2023 - 2025 in Brazil, placing it as the most common type of cancer in women, regardless of age (excluding non-melanoma skin tumors).The high heterogeneity of breast tumors makes their prediction, diagnosis and prognosis difficu…
R-Spondins (RSPOs) comprise a family of secreted glycoproteins known for their important roles in cell proliferation, differentiation and death by inducing the Wnt pathway. Studies have demonstrated the importance of RSPOs in the regulation of several tissue-specific processes, in particular, the proliferation of intestinal stem cells. Aiming at its application in bowel regeneration in sh…
(Only some records are available in English at this moment)
Diabetes mellitus (DM) is a global Health emergency, being one of the main causes of death in the World. Type 1 diabetes (T1D), which represents around 10% of the cases, is characterized by autoimmune destruction of the insulin-producing beta cells of the pancreas, leading to absolute exogenous insulin requirement therapy for patient survival. Whole organ pâncreas transplantation and panc…
In view of the benefits of immunotherapy for the treatment of cancer, compared to conventional treatments, in recent years, the search for new immunotherapies has gained increasing importance. New production strategies aim to improve the performance and effectiveness of these immunotherapeutic drugs.In this project, a new expression strategy for a monoclonal antibody that acts on the PD-1…
(Only some records are available in English at this moment)
Cell lines derived from Chinese hamster ovary cells (CHO), particularly, the CHO-DG44 cell line, are the most widely used for production of biotherapeutic proteins worldwide due to their several advantageous characteristics, such as their high similarity with human cells in terms of post-translational modifications of proteins, despite having a low capacity for terminal sialylation of gly…
Islet cell transplantation represents a very promising therapeutic strategy for type 1 diabetes (T1D). However, upon transplantation, the host immune system initiates a response against the allograft, limiting the long-term efficacy of the transplant and demanding chronic immunosuppression. Microencapsulation emerged as an efficient technology to protect islet cells against the autoimmune…
Techniques based on Tissue Engineering and the regenerative capacity of the intestine represent a great opportunity as potential alternative therapies for Short Bowel Syndrome (SBS). Development of isolated organoid units capable of producing all epithelial cell lines represents an important step and an even greater promise lies is the use of stem cells to generate a Tissue Engineered Sma…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 26 / 15 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 84 / 18 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 122 / 45 | All research grants and scholarships |
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