Mari Cleide Sogayar

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Mari Cleide Sogayar - Bolsa de Productivdade do CNPq ? Nível 1A Graduação em Ciências Biológicas pela Universidade de São Paulo (1968); Mestrado (Master of Sciences) no Biology Dept - University of California (1973) Doutorado em Bioquímica pelo Instituto de Química da Universidade de São Paulo (1977) Pós-doutorado no Dana Farber Cancer Institute, Harvard Medical School, Boston, EUA (1982-84). 1980-2013: Instituto de Química, Dept. Bioquímica, Universidade de São Paulo. 2000-2013: Professora Titular do Depto. de Bioquímica, Instituto de Química, Universidade de São Paulo. Experiência na área de Bioquímica, com ênfase em Biologia Celular e Molecular e Biotecnologia, atuando principalmente nos seguintes temas: a) Controle de proliferação celular e origem de neoplasias, utilizando técnicas de genômica, transcriptômica, genômica funcional e proteômica; b) Diferenciação de células-tronco visando regeneração e reparo de tecidos; c) Terapia Celular baseada em células-tronco e adultas aplicada a doenças degenerativas (transplante clínico de ilhotas pancreáticas humanas em pacientes portadores de diabetes tipo 1 hiperlábil) e engenharia de tecidos. d) Produção de proteínas recombinantes em sistemas de expressão heteróloga (bactérias, células de mamíferos e sistema de baculovírus/células de inseto) para a geração de biofármacos recombinantes como: prolactina humana, leptina humana, hormônio folículo estimulante FSH humano e bovino, amilina/IAPP humana, Fatores de coagulação humanos FVIII, FIX e von Willebrand, Proteínas Morfogenéticas de Osso - BMPs 2, 4 e 7 para reparo ósseo, platelet-derived growth factor humano ? PDGF, vascular endothelial growth factors ? VEGFs, basic fibroblast growth factor ? bFGF, granulocyte and granulocyte and macrophage colony-stimulating factors ? G- and GM-CSFs, R-Spondin, entre outros. Formou 41 Doutores e 14 Mestres, supervisionou mais de 30 pesquisadores pós-doutores e ofereceu treinamento para mais de 40 alunos de Iniciação Científica. Coordena as atividades do grupo NUCEL (Núcleo de Terapia Celular e Molecular) da Universidade de São Paulo (www.nucel.prp.usp.br). (Source: Lattes Curriculum)

Abstract
NUCEL was structured as a translational research Center, having as its mission to act in the Cell and Molecular Therapy area, starting from basic Science centered on molecular mechanisms of cell proliferation and differentiation control and the origin of malignancy to transform the knowledge generated on the bench into products and processes which may be utilized both in medical, odonto...
Regenerative medicine aiming at therapy for chronic degenerative diseases (cancer and diabetes), AP.TEM

Ethics in biomedical research, AR.EXT
World Stem Cells Summit, AR.EXT
Abstract
Endometriosis is a benign gynecologic disorder characterized by the ectopic growth of misplaced endometrial cells. The retrograde menstruation theory, also known as Sampson's theory, proposes that viable endometrial tissue is refluxed through the fallopian tubes during menstruation and implants on peritoneal surface or pelvic organs. This peritoneal reflux could be a necessary but not s...
Endometriosis: molecular bases of immune response, AP.TEM

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(Only some records are available in English at this moment)

Abstract
Diabetes mellitus (DM) is a chronic disease characterized by the absence of insulin production (T1D) or inefficiency of its use by the individual (T2D). Consequently, patients with DM develop hyperglycemia, which, if not controlled, can lead to serious complications in the functioning of vital organs. Conventional T1D treatments are often unable to maintain perfect control of glycemic l...
Characterization of embryonic stem cell transcriptome during its differentiation into insulin-producing cells in the absence and presence of growth/differentiation peptide factors, BP.DR
Regenerative medicine aiming at therapy for chronic degenerative diseases (cancer and diabetes), BP.TT
Abstract
Type 1 diabetes mellitus (DM1) is characterized by autoimmune destruction of insulin-producing pancreatic ² cells, a hormone which has a regulating role of carbohydrate metabolism and blood glucose levels (glycemia). The treatment of DM1 is mainly based on insulin administration, which not always prevent the deleterious effects of hyperglycemia (kidney, eye, neuronal and cardiovascular ...
Influence of peptide growth/differentiation factors in the process of murine embryonic stem cells (mESCs) differentiation into insulin-producing cells (IPCs), BP.IC

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(Only some records are available in English at this moment)

Abstract
Chromatin remodeler proteins have emerged as critical regulators of chromatin structure, playing a major role during development. Since it was found that CHD7 mutations are the major cause of the CHARGE syndrome in humans, this gene has been further studied from the functional point of view. This syndrome is characterized by a series of congenital malformations, including cranial facial...
Role of the chromation remodeler protein Chd7 in chondrogenic differentiation of mesenchymal stem cells, BP.IC
Abstract
Glioblastoma multiforme (GBM) is the most common and lethal type of tumor of the central nervous system.. The glioblastoma stem-like cells (GSCs) represent the most undifferentiated and aggressive state of GBM malignant cells, being postulated to be responsible for reinitiating the tumorigenic process after the standard current therapy. In addition, the complex GBM intra-tumor heterogen...
Comparative analysis of the RECK tumor suppressor gene role in glioblastoma stem cell sub-population and in normal neural stem cells, BP.PD
Abstract
Gliomas are the most common form of primary intracranial malignancy. High-grade gliomas, also called glioblastoma multiforme, are the most frequently encountered, carrying the worst prognosis (12 months life expectancy after diagnosis). Therapy of brain tumor has been limited by the lack of effective methods for drug delivery, therefore, it is mandatory to seek for new approches in glio...
Characterization of ENC1 (NRP/B) isoforms and identification of human glioblastoma-penetrating peptide, BP.DD

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(Only some records are available in English at this moment)

Abstract
Techniques based on Tissue Engineering and the regenerative capacity of the intestine represent a great opportunity as potential alternative therapies for Short Bowel Syndrome (SBS). Development of isolated organoid units capable of producing all epithelial cell lines represents an important step and an even greater promise lies is the use of stem cells to generate a Tissue Engineered S...
Analysis of the therapeutic potential of the human recombinant RSPO1 protein in regeneration of the small intestine in an animal model using tissue engineering technologies, BE.EP.DD
Abstract
Gliomas are the most common form of primary intracranial malignancy. High-grade gliomas, also called glioblastoma multiforme, are the most frequently encountered, carrying the worst prognosis (12 months life expectancy after diagnosis). Therapy of this brain tumor has been limited by the lack of effective methods for drug delivery, therefore, it is mandatory to seek for new approaches t...
Identification and validation of the binding ligands corresponding to two human glioblastoma penetrating peptides, BE.EP.DD
Abstract
Asymmetric cell divisions of progenitor cells are modulated by the Notch signaling pathway and render daughter cells with different differentiation potentials. The tumor suppressor gene Reck was first described by Professor Noda's group in 1998 and codes an 110KDa protein with MMP inhibitory function. Reck regulates the ectodomain shedding of Notch ligands and Reck deficient neural prec...
Analysis of the RECK tumor suppressor gene's role in asymmetric cell division, BE.EP.PD

See more Completed scholarships abroad

(Only some records are available in English at this moment)

Use this Research Supported by FAPESP (BV/FAPESP) channel only to send messages referring to FAPESP-funded scientific projects.

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications	19
Citations	100
Cit./Article	5.3
Data from Web of Science

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SILVA PAIVA, KATIUCIA BATISTA; ZAMBUZZI, WILLIAN FERNANDO; ACCORSI-MENDONCA, THAIS; TAGA, RUMIO; NUNES, FABIO DAUMAS; SOGAYAR, MARI CLEIDE; GRANJEIRO, JOSE MAURO. Rat forming incisor requires a rigorous ECM remodeling modulated by MMP/RECK balance. Journal of Molecular Histology, v. 40, n. 3, p. 201-207, JUN 2009. Web of Science Citations: 9. (01/10707-7, 07/04148-1, 07/00216-2, 99/10655-5)

TAKAMORI‚ E.R.; CRUZ‚ R.; GONÇALVEZ‚ F.; ZANETTI‚ R.V.; ZANETTI‚ A.; GRANJEIRO‚ J.M.. Effect of roughness of zirconia and titanium on fibroblast adhesion. ARTIFICIAL ORGANS, v. 32, n. 4, p. 305-309, 2008. (99/06460-4, 01/10707-7)

CARDOSO DE OLIVEIRA DEMARCHI, ANA CLAUDIA; ZAMBUZZI, WILLIAN FERNANDO; SILVA PAIVA, KATIUCIA BATISTA; DA SILVA-VALENZUELA, MARIA DAS GRACAS; NUNES, FABIO DAUMAS; SAVIO FIGUEIRA, RITA DE CASSIA; SASAHARA, REGINA MAKI; ALMEIDA DEMASI, MARCOS ANGELO; BROCHADO WINNISCHOFER, SHEILA MARIA; SOGAYAR, MARI CLEIDE; et al. Development of secondary palate requires strict regulation of ECM remodeling: sequential distribution of RECK, MMP-2, MMP-3, and MMP-9. Cell and Tissue Research, v. 340, n. 1, p. 61-69, APR 2010. Web of Science Citations: 15. (01/10707-7)

MENEZES‚ R.; BRAMANTE‚ C.M.; DA SILVA PAIVA‚ K.B.; LETRA‚ A.; CARNEIRO‚ E.; FERNANDO ZAMBUZZI‚ W.; GRANJEIRO‚ J.M.. Receptor activator NF [kappa] B-ligand and osteoprotegerin protein expression in human periapical cysts and granulomas. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, v. 102, n. 3, p. 404-409, 2006. (01/10707-7)

LOURO‚ R.; NAKAYA‚ H.; AMARAL‚ P.; FESTA‚ F.; SOGAYAR‚ M.; DA SILVA‚ A.; VERJOVSKI-ALMEIDA‚ S.; REIS‚ E.. Androgen responsive intronic non-coding RNAs. BMC Biology, v. 5, n. 1, p. 4, 2007. (01/10707-7, 02/13283-6)

ASSIS-RIBAS, THAIS; FORNI, MARIA FERNANDA; BROCHADO WINNISCHOFER, SHEILA MARIA; SOGAYAR, MARI CLEIDE; TROMBETTA-LIMA, MARINA. Extracellular matrix dynamics during mesenchymal stem cells differentiation. Developmental Biology, v. 437, n. 2, p. 63-74, MAY 15 2018. Web of Science Citations: 12. (16/22298-0, 16/18277-7, 15/25776-7, 16/05311-2, 15/26328-8)

MAIA LOBBA, ALINE RAMOS; OLIVEIRA CARREIRA, ANA CLAUDIA; DUTRA CERQUEIRA, OTTO LUIZ; FUJITA, ANDRE; DEOCESANO-PEREIRA, CARLOS; BUENO OSORIO, CYNTHIA APARECIDA; SOARES, FERNANDO AUGUSTO; RAMESHWAR, PRANELA; SOGAYAR, MARI CLEIDE. High CD90 (THY-1) expression positively correlates with cell transformation and worse prognosis in basal-like breast cancer tumors. PLoS One, v. 13, n. 6, JUN 27 2018. Web of Science Citations: 1.

DEOCESANO-PEREIRA, CARLOS; MACHADO, RAQUEL A. C.; CHUDZINSKI-TAVASSI, ANA MARISA; SOGAYAR, MARI CLEIDE. Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 7, APR 2020. Web of Science Citations: 0. (15/50040-4, 16/05311-2)

SPINDOLA, ADAUTO; TARGA, ADRIANO D. S.; RODRIGUES, LAIS SOARES; WINNISCHOFER, SHEILA MARIA BROCHADO; LIMA, MARCELO M. S.; SOGAYAR, MARI CLEIDE; TROMBETTA-LIMA, MARINA. Increased Mmp/Reck Expression Ratio Is Associated with Increased Recognition Memory Performance in a Parkinson's Disease Animal Model. Molecular Neurobiology, v. 57, n. 2, p. 837-847, FEB 2020. Web of Science Citations: 0. (16/18277-7, 16/05311-2, 15/26328-8)

LEVIN, GABRIEL; COELHO, TATIANE MALDONADO; NOBREGA, NATHALI GUIMARAES; TROMBETTA-LIMA, MARINA; SOGAYAR, MARI CLEIDE; OLIVEIRA CARREIRA, ANA CLAUDIA. Spatio-temporal expression profile of matrix metalloproteinase (Mmp) modulators Reck and Sparc during the rat ovarian dynamics. Reproductive Biology and Endocrinology, v. 16, NOV 13 2018. Web of Science Citations: 2. (13/18842-8)

TROMBETTA-LIMA, MARINA; BROCHADO WINNISCHOFER, SHEILA MARIA; ALMEIDA DEMASI, MARCOS ANGELO; ASTORINO FILHO, RENATO; OLIVEIRA CARREIRA, ANA CLAUDIA; WEI, BEIYANG; RIBAS, THAIS DE ASSIS; KONIG, MICHELLE SILBERSPITZ; BOWMAN-COLIN, CHRISTIAN; OBA-SHINJO, SUELI MIEKO; et al. Isolation and characterization of novel RECK tumor suppressor gene splice variants. ONCOTARGET, v. 6, n. 32, p. 33120-33133, OCT 20 2015. Web of Science Citations: 8. (01/10707-7, 04/12133-6)

NOGUEIRA, ADRIANO BARRETO; SOGAYAR, MARI CLEIDE; COLQUHOUN, ALISON; SIQUEIRA, SHEILA APARECIDA; NOGUEIRA, ARIEL BARRETO; MARCHIORI, PAULO EURIPEDES; TEIXEIRA, MANOEL JACOBSEN. Existence of a potential neurogenic system in the adult human brain. JOURNAL OF TRANSLATIONAL MEDICINE, v. 12, MAR 22 2014. Web of Science Citations: 25.

THAIS ACCORSI-MENDONÇA; MÁRCIO BALTAZAR CONZ; TERESA CRISTINA BARROS; LÍDIA ÁGATA DE SENA; GLÓRIA DE ALMEIDA SOARES; JOSÉ MAURO GRANJEIRO. Physicochemical characterization of two deproteinized bovine xenografts. Brazilian Oral Research, v. 22, n. 1, p. 5-10, Mar. 2008. (99/10655-5, 01/10707-7)

ESTHER RIEKO TAKAMORI; EDUARDO ALEIXO FIGUEIRA; RUMIO TAGA; MARI CLEIDE SOGAYAR; JOSÉ MAURO GRANJEIRO. Evaluation of the cytocompatibility of mixed bovine bone. Brazilian Dental Journal, v. 18, n. 3, p. 179-184, 2007. (01/10707-7, 99/06460-4)

HALCSIK, ERIK; FORNI, MARIA FERNANDA; FUJITA, ANDRE; VERANO-BRAGA, THIAGO; JENSEN, OLE NORREGAARD; SOGAYAR, MARI CLEIDE. New insights in osteogenic differentiation revealed by mass spectrometric assessment of phosphorylated substrates in murine skin mesenchymal cells. BMC CELL BIOLOGY, v. 14, OCT 22 2013. Web of Science Citations: 9.

NOGUEIRA, ADRIANO BARRETO; NOGUEIRA, ARIEL BARRETO; COSTA, ANDERSON LINO; LIMA, FABIANA ROBERTO; SIQUEIRA, SHEILA APARECIDA; TEIXEIRA, MANOEL JACOBSEN. Hepatocellular carcinoma may display elevated nestin expression in endothelial cells: experimental study. São Paulo Medical Journal, v. 133, n. 2, p. 135-140, MAR-APR 2015. Web of Science Citations: 0.

LEAL-LOPES, CAMILA; GRAZIOLI, GISELLA; MARES-GUIA, THIAGO R.; COELHO-SAMPAIO, TATIANA; SOGAYAR, MARI CLEIDE. Polymerized laminin incorporation into alginate-based microcapsules reduces pericapsular overgrowth and inflammation. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 13, n. 10, AUG 2019. Web of Science Citations: 0. (16/05311-2, 13/00664-6)

ADRIANO BARRETO NOGUEIRA. Mapping of potential neurogenic niche in the human temporal lobe. Arquivos de Neuro-Psiquiatria, v. 72, n. 10, p. -, Out. 2014.

VELLOSO, FERNANDO J.; TROMBETTA-LIMA, MARINA; ANSCHAU, VALESCA; SOGAYAR, MARI C.; CORREA, RICARDO G.. NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer. BIOSCIENCE REPORTS, v. 39, n. 4, APR 30 2019. Web of Science Citations: 0. (16/05311-2)

LEVIN, GABRIEL; KOGA, BRUNA ANDRADE AGUIAR; BELCHIOR, GUSTAVO GROSS; CARREIRA, ANA CLAUDIA OLIVEIRA; SOGAYAR, MARI CLEIDE. Production, purification and characterization of recombinant human R-spondin1 (RSPO1) protein stably expressed in human HEK293 cells. BMC Biotechnology, v. 20, n. 1, JAN 20 2020. Web of Science Citations: 0. (17/01072-6, 15/11128-3, 16/05311-2)

MÉTODO PARA CLONAGEM, EXPRESSÃO E PURIFICAÇÃO DO POLIPEPTÍDEO AMILÓIDE DAS ILHOTAS PANCREÁTICAS HUMANAS PI0400735-2 - Universidade Federal do Rio de Janeiro (UFRJ). Dahabada Helena José Lopes; Sérgio Teixeira Ferreira; Mari Cleide Sogayar; Theri Leica Degaki; Christian Colin - March 2004, 23

1 / 1	Ongoing research grants
26 / 15	Completed research grants
4 / 4	Ongoing scholarships in Brazil
75 / 9	Completed scholarships in Brazil
5 / 5	Completed scholarships abroad
111 / 34	All research grants and scholarships

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